We are analyzing https://link.springer.com/article/10.1186/bcr2938.

Title:
Epithelial-mesenchymal transition, cancer stem cells and treatment resistance | Breast Cancer Research
Description:
Breast cancer relapse, in a large number of patients, after initial response to standard of care therapy warrants development of novel therapies against recurrent and metastatic cancer. Cancer stem cells (CSCs), present in breast tumors while being intrinsically resistant to conventional therapy, have the ability to self renew and cause tumor recurrence. The residual tumors after therapy, with dramatic enrichment of the CSCs, have all the hallmarks of epithelial- mesenchymal transition (EMT). This review will focus on the link between EMT, CSCs and treatment resistance, since a better understanding of these interactions will allow us to effectively target the residual population after therapy.
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Keywords {🔍}

cancer, pubmed, cells, article, breast, google, scholar, emt, cas, cscs, stem, tumor, transition, tumors, cell, epithelialmesenchymal, growth, factor, resistance, expression, central, epithelial, treatment, therapy, role, zeb, versican, metastatic, mesenchymal, mammary, properties, increase, chang, therapies, ability, met, development, metastasis, gene, signature, nature, markers, disease, factors, csc, human, authors, research, relapse, patients,

Topics {✒️}

platelet-derived growth factor cd44+/cd24-/low-positive cells node-negative breast cancer cd44+/cd24-/low cells metanephric mesenchyme mammary stem cells transforming growth factor targeting epithelial-mesenchymal transition cd44+/cd24-/low levels estrogen receptor-positive epidermal growth factor serum-free media supplemented cancer stem cells ultra-low attachment conditions undergo mesenchymal-epithelial transformation phosphatidylinositol-3-kinase/akt pathway facilitate cell-cell interactions letrozole/chemotherapy-treated specimens hepatocyte growth factor fibroblast growth factor cell stem cell breast cancer cells epithelial- mesenchymal transition epithelial-mesenchymal transition mesenchymal-epithelial transition stem cell markers stem cell biology stem cell traits emt-inducing transcription factors cd44+/cd24-/low her2-positive cancers [1 mouse mammary gland mammosphere-forming efficiency disseminated cancer cells normal stem cells her2-positive disease cancer cells acquire t-cell factor stem cell characteristics natl cancer inst subtype called claudin-low breast cancer prior breast cancer relates human endometrial cancer privacy choices/manage cookies kerns sa zhu epithelial-mesenchymal transitions mesenchymal-epithelial transitions disseminated tumor cells epithelio-mesenchymal transformation

Questions {❓}

Jones RJ, Matsui WH, Smith BD: Cancer stem cells: are we missing the target?

Schema {🗺️}

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         headline:Epithelial-mesenchymal transition, cancer stem cells and treatment resistance
         description:Breast cancer relapse, in a large number of patients, after initial response to standard of care therapy warrants development of novel therapies against recurrent and metastatic cancer. Cancer stem cells (CSCs), present in breast tumors while being intrinsically resistant to conventional therapy, have the ability to self renew and cause tumor recurrence. The residual tumors after therapy, with dramatic enrichment of the CSCs, have all the hallmarks of epithelial- mesenchymal transition (EMT). This review will focus on the link between EMT, CSCs and treatment resistance, since a better understanding of these interactions will allow us to effectively target the residual population after therapy.
         datePublished:2012-01-19T00:00:00Z
         dateModified:2012-01-19T00:00:00Z
         pageStart:1
         pageEnd:5
         sameAs:https://doi.org/10.1186/bcr2938
         keywords:
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            Disseminate Tumor Cell
            Metanephric Mesenchyme
            Breast CSCs
            Breast Cancer Relapse
            Cancer Research
            Oncology
            Surgical Oncology
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               type:Person
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      headline:Epithelial-mesenchymal transition, cancer stem cells and treatment resistance
      description:Breast cancer relapse, in a large number of patients, after initial response to standard of care therapy warrants development of novel therapies against recurrent and metastatic cancer. Cancer stem cells (CSCs), present in breast tumors while being intrinsically resistant to conventional therapy, have the ability to self renew and cause tumor recurrence. The residual tumors after therapy, with dramatic enrichment of the CSCs, have all the hallmarks of epithelial- mesenchymal transition (EMT). This review will focus on the link between EMT, CSCs and treatment resistance, since a better understanding of these interactions will allow us to effectively target the residual population after therapy.
      datePublished:2012-01-19T00:00:00Z
      dateModified:2012-01-19T00:00:00Z
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      keywords:
         Cancer Stem Cell
         Disseminate Tumor Cell
         Metanephric Mesenchyme
         Breast CSCs
         Breast Cancer Relapse
         Cancer Research
         Oncology
         Surgical Oncology
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                  address:
                     name:Weil Cornell Medical School, USA
                     type:PostalAddress
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            type:Person
            name:Nicholas M Tan
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                  name:Methodist Hospital Cancer Center
                  address:
                     name:Methodist Hospital Cancer Center, Houston, USA
                     type:PostalAddress
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            name:Jenny C Chang
            affiliation:
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               type:PostalAddress
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      affiliation:
            name:Weil Cornell Medical School
            address:
               name:Weil Cornell Medical School, USA
               type:PostalAddress
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      name:Nicholas M Tan
      affiliation:
            name:Methodist Hospital Cancer Center
            address:
               name:Methodist Hospital Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Jenny C Chang
      affiliation:
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            address:
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               type:PostalAddress
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      name:Weil Cornell Medical School, USA
      name:Methodist Hospital Cancer Center, Houston, USA
      name:Methodist Hospital Cancer Center, Houston, USA

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