We are analyzing https://link.springer.com/article/10.1186/bcr2585.

Title:
Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression | Breast Cancer Research
Description:
Breast cancer is the most common cancer among women, and despite significant advances in diagnosing and treating it, metastatic spread of cancer cells results in a high mortality rate. Epithelial-to-mesenchymal transition (EMT) is an embryonic program in which epithelial cells lose their characteristics and gain mesenchymal features. Therefore, EMT might play a very important role during malignant tumour progression. In this review we summarise recent advances in breast cancer research with a particular focus on the transcription factors Snail1 and Twist1. Besides discussing the role of EMT in normal mammary gland development, we describe regulatory mechanisms involving newly discovered upstream regulators and microRNAs, the association of EMT with breast cancer stem cells, and the involvement of the tumour microenvironment in breast cancer progression.
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Keywords {🔍}

cancer, pubmed, breast, cells, article, google, scholar, cas, snail, cell, emt, twist, expression, tumour, mammary, metastasis, central, epithelial, stem, transition, factors, development, transcription, tumours, human, progression, role, markers, zeb, ecadherin, family, genes, gland, epithelialmesenchymal, cancers, gene, biol, res, basallike, growth, phenotype, carcinoma, receptor, nat, invasion, snai, factor, resistance, berx, mesenchymal,

Topics {✒️}

hypoxia-inducible factor-1-dependent repression cd44+/cd24- profile tgf-beta induced transdifferentiation trkb-induced epithelial-mesenchymal transition transforming growth factor-beta basic helixloop-helix factors carg box-binding factor basic helixloop-helix proteins y-box transcription factor zinc-finger transcription factors cop9 signalosome 2 cop9 signalosome metaplastic breast cancers ras oncogene-induced senescence v12h-ras-transformed hmles her2/neu-transformed hmles smad-binding element nearby key signalling nodes hif-1alpha promotes metastasis integrated genomic-proteomic approach tumour necrosis factor-alpha gene expression profiles breast cancer-related therapies pro-metastatic gene rhoc greater mammosphere-forming ability cancer search search e-cadherin repressors participate triple-negative breast cancers cd44+/cd24- cells showed epithelial-mesenchymal transition markers ligand-activated erα forms cd44+/cd24- expression pattern claudin-low tumor cells inflammation-induced cell migration zinc-finger protein slug regulates e-cadherin tgf-β-induced emt epithelial-mesenchymal transition phenotype tgf-β induces hmga2 mi-2/nurd complex subunit secrete pro-inflammatory cytokines breast cancer relates enriched cd44+/cd24- cells twist-snail axis critical breast cancer research geert berx heterogeneous e-cadherin expression tumor-promoting inactivation e-cadherin repressors zeb1 represses nf-kappab activity

Questions {❓}

Bertucci F, Finetti P, Cervera N, Esterni B, Hermitte F, Viens P, Birnbaum D: How basal are triple-negative breast cancers?
Peinado H, Olmeda D, Cano A: Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
Snail1 and Twist1 as criteria in breast cancer classification?

Schema {🗺️}

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            Lobular Carcinoma
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      headline:Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression
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         Surgical Oncology
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