We are analyzing https://link.springer.com/article/10.1186/bcr2111.

Title:
Breast cancer stem cells: implications for therapy of breast cancer | Breast Cancer Research
Description:
The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour-associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells.
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Keywords {🔍}

cells, cancer, stem, pubmed, breast, cell, google, scholar, article, cas, tumour, tumours, mammary, human, expression, targeting, antigens, role, bcscs, target, disease, shown, central, metastatic, tissue, res, treatment, potential, immunotherapy, therapy, antigen, patients, differentiated, development, capable, epithelial, clinical, population, signalling, differentiation, selfrenewal, phenotype, normal, gland, nature, important, dendritic, characteristics, celllike, model,

Topics {✒️}

granulocyte-macrophage colony-stimulating factor tumour necrosis factor-alpha-matured mage-3a1 peptide-pulsed mature p53-peptide-pulsed dendritic cells mmtv-c-neu transgenic carcinomas wnt/beta-catenin signaling pathway human colon-cancer-initiating cells human er-stem/progenitor cells peptide-pulsed dendritic cells cytotoxic t-lymphocyte responses x-inactivation patch size professional antigen-presenting cells monocyte-derived dcs pulsed beta-catenin signaling activity cytotoxic t-lymphocyte antigen her2-overexpressing breast cancer dual-tyrosine kinase inhibitor erbb-beta-catenin complexes active anti-apoptotic pathways bone morpho-genetic protein serum-free medium supplemented stem/progenitor cell properties cd133+cells grew exponentially dc-based vaccine prevented adoptive t-cell transfer stimulate t-cell proliferation current anti-cancer therapy functional milk-secreting alveoli acute myeloid leukaemia early-onset breast carcinomas limiting-dilution assay showing dc/irradiated tumour vaccine original tumour-initiating cells stem cell niche cd44+/cd24low tumourigenic fraction stemness-related tumor antigens organ-specific process undertaken mage-3a1 peptide transit-amplifying cell stem cell niches cleared fat pads abc transporter bcrp1/abcg2 acute promyeloctyic leukaemia cell stem cell acute promyelocytic leukemia breast cancer research transit-amplifying cells x-chromosome inactivation studies stem cell antigen cytotoxic t-lymphocyte

Questions {❓}

Behbod F, Rosen JM: Will cancer stem cells provide new therapeutic targets?
What, then, is the cell type that can be transformed and give rise to both differentiated and undifferentiated cells?
Cancer 'stem' cells and CD133: what's in the name?

Schema {🗺️}

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         headline:Breast cancer stem cells: implications for therapy of breast cancer
         description:The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour-associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells.
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      headline:Breast cancer stem cells: implications for therapy of breast cancer
      description:The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour-associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells.
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      name:Queensland Institute of Medical Research, Royal Brisbane Hospital Post Office, Brisbane, Australia
      name:Griffith University, Nathan, Australia
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