We are analyzing https://link.springer.com/article/10.1186/2001-1326-2-3.

Title:
Mechanisms of chemoresistance in cancer stem cells | Clinical and Translational Medicine
Description:
Chemotherapy is one of the standard methods of treatment in many cancers. While chemotherapy is often capable of inducing cell death in tumors and reducing the tumor bulk, many cancer patients experience recurrence and ultimately death because of treatment failure. In recent years, cancer stem cells (CSCs) have gained intense interest as key tumor-initiating cells that may also play an integral role in recurrence following chemotherapy. As such, a number of mechanisms of chemoresistance have been identified in CSCs. In this review, we describe a number of these mechanisms of chemoresistance including ABC transporter expression, aldehyde dehydrogenase (ALDH) activity, B-cell lymphoma-2 (BCL2) related chemoresistance, enhanced DNA damage response and activation of key signaling pathways. Furthermore, we evaluate studies that demonstrate potential methods for overcoming chemoresistance and treating chemoresistant cancers that are driven by CSCs. By understanding how tumor-initiating cells such as CSCs escape chemotherapy, more informed approaches to treating cancer will develop and may improve clinical outcomes for cancer patients.
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Keywords {🔍}

cancer, cells, pubmed, google, scholar, cscs, article, cas, stem, cell, chemoresistance, tumor, aldh, central, bcl, pathway, activity, human, mechanisms, tumors, signaling, resistance, breast, colon, res, role, normal, treatment, identified, abc, aldehyde, dehydrogenase, dna, chemotherapy, expression, studies, demonstrated, activation, identification, chk, number, leukemia, ovarian, pathways, specific, mechanism, protein, notch, potential, expressed,

Topics {✒️}

edward kai-hua chow interferon-alpha/5-fluorouracil combination therapy wnt/beta-catenin signaling contributes wnt/β-catenin signaling pathway article download pdf esa+cd44+ colon cscs wnt/beta-catenin pathway akt/pkb survival pathway acute b-cell leukemia peri-implantation embryonic lethality article abdullah bcl-2-ig fusion transcripts anti-apoptotic protein bcl-2 anti-apoptotic genes bcl stem/progenitor cell differentiation bcl-x-deficient mice ovarian cancer-initiating cells cd44+/cd24- markers bcl-2-related protein a1a oncogenic serine/threonine kinase bcl-2-related a1 gene rad3-related function abrogates b-cell lymphoma-2 pro-apoptotic proteins bax tumor-initiating cell fraction disulfiram modulated ros-mapk key tumor-initiating cell neck squamous cancer cd34+/cd38- aml cells c-kit+ ovarian cscs key tumor-initiating cells c-kit mediates chemoresistance chemoresistant tumor-initiating cscs beta-catenin impairs prevent chemotherapy-mediated apoptosis cyclophosphamide-resistant l1210 leukemia cell line derived pro-apoptotic proteins bcl2 csc-related signaling pathways atp-binding cassette pro-survival members chemoresistance-related signaling pathways glioma stem cells bcl-2 family members leukemic stem cells cancer stem cell cancer stem cell c6 cell line aldh1a1-targeted sirna resulted aldh-mediated cyclophosphamide resistance

Schema {🗺️}

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         headline:Mechanisms of chemoresistance in cancer stem cells
         description:Chemotherapy is one of the standard methods of treatment in many cancers. While chemotherapy is often capable of inducing cell death in tumors and reducing the tumor bulk, many cancer patients experience recurrence and ultimately death because of treatment failure. In recent years, cancer stem cells (CSCs) have gained intense interest as key tumor-initiating cells that may also play an integral role in recurrence following chemotherapy. As such, a number of mechanisms of chemoresistance have been identified in CSCs. In this review, we describe a number of these mechanisms of chemoresistance including ABC transporter expression, aldehyde dehydrogenase (ALDH) activity, B-cell lymphoma-2 (BCL2) related chemoresistance, enhanced DNA damage response and activation of key signaling pathways. Furthermore, we evaluate studies that demonstrate potential methods for overcoming chemoresistance and treating chemoresistant cancers that are driven by CSCs. By understanding how tumor-initiating cells such as CSCs escape chemotherapy, more informed approaches to treating cancer will develop and may improve clinical outcomes for cancer patients.
         datePublished:2013-01-17T00:00:00Z
         dateModified:2013-01-17T00:00:00Z
         pageStart:1
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         license:https://creativecommons.org/licenses/by/2.0
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            Medicine/Public Health
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ScholarlyArticle:
      headline:Mechanisms of chemoresistance in cancer stem cells
      description:Chemotherapy is one of the standard methods of treatment in many cancers. While chemotherapy is often capable of inducing cell death in tumors and reducing the tumor bulk, many cancer patients experience recurrence and ultimately death because of treatment failure. In recent years, cancer stem cells (CSCs) have gained intense interest as key tumor-initiating cells that may also play an integral role in recurrence following chemotherapy. As such, a number of mechanisms of chemoresistance have been identified in CSCs. In this review, we describe a number of these mechanisms of chemoresistance including ABC transporter expression, aldehyde dehydrogenase (ALDH) activity, B-cell lymphoma-2 (BCL2) related chemoresistance, enhanced DNA damage response and activation of key signaling pathways. Furthermore, we evaluate studies that demonstrate potential methods for overcoming chemoresistance and treating chemoresistant cancers that are driven by CSCs. By understanding how tumor-initiating cells such as CSCs escape chemotherapy, more informed approaches to treating cancer will develop and may improve clinical outcomes for cancer patients.
      datePublished:2013-01-17T00:00:00Z
      dateModified:2013-01-17T00:00:00Z
      pageStart:1
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         Cancer
         Cancer stem cells
         Medicine/Public Health
         general
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            name:Lissa Nurrul Abdullah
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                     name:Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Edward Kai-Hua Chow
            affiliation:
                  name:National University of Singapore
                  address:
                     name:Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
                  name:National University of Singapore
                  address:
                     name:Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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Person:
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               type:PostalAddress
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      name:Edward Kai-Hua Chow
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               type:PostalAddress
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PostalAddress:
      name:Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
      name:Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
      name:Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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