We are analyzing https://link.springer.com/article/10.1186/1756-8722-5-12.

Title:
Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases | Journal of Hematology & Oncology
Description:
The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). They are generally associated with signs of aggressiveness and poor clinical outcome. Because of this, a systematic determination of ASXL1 mutational status in myeloid malignancies should help in prognosis assessment.
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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

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         description:The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). They are generally associated with signs of aggressiveness and poor clinical outcome. Because of this, a systematic determination of ASXL1 mutational status in myeloid malignancies should help in prognosis assessment.
         datePublished:2012-03-21T00:00:00Z
         dateModified:2012-03-21T00:00:00Z
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            Oncology
            Hematology
            Cancer Research
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ScholarlyArticle:
      headline:Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases
      description:The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). They are generally associated with signs of aggressiveness and poor clinical outcome. Because of this, a systematic determination of ASXL1 mutational status in myeloid malignancies should help in prognosis assessment.
      datePublished:2012-03-21T00:00:00Z
      dateModified:2012-03-21T00:00:00Z
      pageStart:1
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         Gene mutations
         Myeloid diseases
         Oncology
         Hematology
         Cancer Research
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      name:Aix-Marseille Univ, Marseille, France
      name:Département de BioPathologie, Institut Paoli-Calmettes, Marseille, France
      name:Départements d'Oncologie Moléculaire et de Biopathologie, CRCM, Institut Paoli-Calmettes, Leï Roure, France
      name:Centre de Recherche en Cancérologie de Marseille; Laboratoire d'Oncologie Moléculaire; UMR1068 Inserm, Institut Paoli-Calmettes, Marseille, France
      name:Aix-Marseille Univ, Marseille, France
      name:Centre de Recherche en Cancérologie de Marseille; Laboratoire d'Oncologie Moléculaire; UMR1068 Inserm, Institut Paoli-Calmettes, Marseille, France
      name:Aix-Marseille Univ, Marseille, France
      name:Centre de Recherche en Cancérologie de Marseille; Laboratoire d'Oncologie Moléculaire; UMR1068 Inserm, Institut Paoli-Calmettes, Marseille, France
      name:Département de BioPathologie, Institut Paoli-Calmettes, Marseille, France
      name:Centre de Recherche en Cancérologie de Marseille; Laboratoire d'Oncologie Moléculaire; UMR1068 Inserm, Institut Paoli-Calmettes, Marseille, France
      name:Département de BioPathologie, Institut Paoli-Calmettes, Marseille, France
      name:Centre de Recherche en Cancérologie de Marseille; Laboratoire d'Oncologie Moléculaire; UMR1068 Inserm, Institut Paoli-Calmettes, Marseille, France

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