
NCBI . NLM . NIH . GOV {
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Title[redir]:
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia - PMC
Description:
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and assessed the frequency of the identified somatic mutations in 94 T-cell ...
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Keywords {🔍}
mutations, doi, cases, etp, supplementary, scholar, google, pubmed, genes, tall, acute, gene, ilr, fig, data, identified, pmc, expression, mutation, cell, cells, sequence, tcell, leukaemia, article, alterations, performed, haematopoietic, analysis, sjtall, lymphoblastic, sequencing, nonetp, leukemia, nature, gata, table, free, jak, runx, myeloid, structural, human, genetic, development, somatic, receptor, normal, blood, signalling,
Topics {✒️}
full-length etv-ino80d transcript supplementary tables nihms348037-supplement-supplementary_tables t-cell-lineage developmental programme empty mscv-ires-gfp vector full-text html version performing single-nucleotide polymorphism il7r-mutant-expressing cells bone marrow aspirates early t-lineage progenitors26 long-term multilineage engraftment enhanced replating compared leukaemic stem-cell signature array-based genomic resequencing impaired dna-binding affinity enhanced colony replating high-risk b-progenitor aml1/eto fusion transcript paired-end sequencing strategy cytokine-independent cell growth pmc beta search induce factor-independent growth acute lymphoblastic leukaemia stem cell leukaemia prc2-mediated gene silencing silent single-nucleotide variants project sample management acute lymphoblastic leukemia haematopoietic transcription factors acute megakaryoblastic leukaemia stem cell maintenance marked enrichment compared acute myeloid leukaemia jak-stat signalling pathways runx1–evx1 rearrangement arising autosomal recessive lissencephaly b-cell lineage mutant alleles resulted signature demonstrated enrichment il7r mutant alleles mutant il7r alleles tel/aml1 fusion resulting gfp-positive cells methods summary figures show mutations haematopoietic cells coupled mature haematopoietic progenitor early maturational stage siteman cancer center united states government washington university
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