We are analyzing https://link.springer.com/article/10.1186/1479-5876-10-228.

Title:
Roles of microRNA on cancer cell metabolism | Journal of Translational Medicine
Description:
Advanced studies of microRNAs (miRNAs) have revealed their manifold biological functions, including control of cell proliferation, cell cycle and cell death. However, it seems that their roles as key regulators of metabolism have drawn more and more attention in the recent years. Cancer cells display increased metabolic autonomy in comparison to non-transformed cells, taking up nutrients and metabolizing them in pathways that support growth and proliferation. MiRNAs regulate cell metabolic processes through complicated mechanisms, including directly targeting key enzymes or transporters of metabolic processes and regulating transcription factors, oncogenes / tumor suppressors as well as multiple oncogenic signaling pathways. MiRNAs like miR-375, miR-143, miR-14 and miR-29b participate in controlling cancer cell metabolism by regulating the expression of genes whose protein products either directly regulate metabolic machinery or indirectly modulate the expression of metabolic enzymes, serving as master regulators, which will hopefully lead to a new therapeutic strategy for malignant cancer. This review focuses on miRNA regulations of cancer cell metabolism,including glucose uptake, glycolysis, tricarboxylic acid cycle and insulin production, lipid metabolism and amino acid biogenesis, as well as several oncogenic signaling pathways. Furthermore, the challenges of miRNA-based strategies for cancer diagnosis, prognosis and therapeutics have been discussed.
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Keywords {🔍}

pubmed, google, scholar, cas, cancer, metabolism, mirnas, cell, expression, glucose, mirna, central, metabolic, microrna, cells, regulation, regulate, glycolysis, glut, micrornas, signaling, genes, lipid, pathways, acid, mira, including, targets, regulating, gene, human, pathway, biol, mirb, protein, target, cycle, tumor, amino, growth, targeting, biomarkers, levels, regulator, cholesterol, pancreatic, roles, key, insulin, figure,

Topics {✒️}

[2fe-2s] iron-sulfur clusters oxysterol-binding-protein-related-protein risc oxysterol-binding-protein-related-protein 8 pgc-1β/errγ transcriptional pathway metabolic-stress-induced signaling pathways 3t3-l1 pre-adipocyte differentiation p53/p21waf1/cip1-dependent mechanism 3’-phosphoinositide-dependent protein kinase-1 ras-erk mapk cascade rna-induced silenced complex semi-quantitative rt-pcr helix-loop-helix proteins inducing g0/g1 arrest high-density lipoprotein synthesis najafi-shoushtari sh akt/mtor signaling pathways reverts myc-induced growth defined 79 multiple-gene-nodes open access article mirna expression profiles article download pdf mirna-based therapeutic interventions pi3k/akt/mtor pathway pi3k-akt-mtor pathway fatty acid oxidation smooth muscle-enriched mir-145 pri-mirna transcript extends key post-transcriptional regulators carnitine palmitoyltransferase 1a irreversible rate-limiting steps α-ketoacid dehydrogenase mir-29b exerts effects amino acid metabolism privacy choices/manage cookies fatty-acid metabolism fatty acid metabolism oncogenic signaling pathways mammalian liver-specific microrna beta-cell mass amino acid catabolism fatty acid synthase open syst biol pancreatic beta-cells subcomponent binding protein full size image akt signaling pathways multiple metabolic processes authors’ original file proc nutr soc hepatic fatty-acid

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         headline:Roles of microRNA on cancer cell metabolism
         description:Advanced studies of microRNAs (miRNAs) have revealed their manifold biological functions, including control of cell proliferation, cell cycle and cell death. However, it seems that their roles as key regulators of metabolism have drawn more and more attention in the recent years. Cancer cells display increased metabolic autonomy in comparison to non-transformed cells, taking up nutrients and metabolizing them in pathways that support growth and proliferation. MiRNAs regulate cell metabolic processes through complicated mechanisms, including directly targeting key enzymes or transporters of metabolic processes and regulating transcription factors, oncogenes / tumor suppressors as well as multiple oncogenic signaling pathways. MiRNAs like miR-375, miR-143, miR-14 and miR-29b participate in controlling cancer cell metabolism by regulating the expression of genes whose protein products either directly regulate metabolic machinery or indirectly modulate the expression of metabolic enzymes, serving as master regulators, which will hopefully lead to a new therapeutic strategy for malignant cancer. This review focuses on miRNA regulations of cancer cell metabolism,including glucose uptake, glycolysis, tricarboxylic acid cycle and insulin production, lipid metabolism and amino acid biogenesis, as well as several oncogenic signaling pathways. Furthermore, the challenges of miRNA-based strategies for cancer diagnosis, prognosis and therapeutics have been discussed.
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      headline:Roles of microRNA on cancer cell metabolism
      description:Advanced studies of microRNAs (miRNAs) have revealed their manifold biological functions, including control of cell proliferation, cell cycle and cell death. However, it seems that their roles as key regulators of metabolism have drawn more and more attention in the recent years. Cancer cells display increased metabolic autonomy in comparison to non-transformed cells, taking up nutrients and metabolizing them in pathways that support growth and proliferation. MiRNAs regulate cell metabolic processes through complicated mechanisms, including directly targeting key enzymes or transporters of metabolic processes and regulating transcription factors, oncogenes / tumor suppressors as well as multiple oncogenic signaling pathways. MiRNAs like miR-375, miR-143, miR-14 and miR-29b participate in controlling cancer cell metabolism by regulating the expression of genes whose protein products either directly regulate metabolic machinery or indirectly modulate the expression of metabolic enzymes, serving as master regulators, which will hopefully lead to a new therapeutic strategy for malignant cancer. This review focuses on miRNA regulations of cancer cell metabolism,including glucose uptake, glycolysis, tricarboxylic acid cycle and insulin production, lipid metabolism and amino acid biogenesis, as well as several oncogenic signaling pathways. Furthermore, the challenges of miRNA-based strategies for cancer diagnosis, prognosis and therapeutics have been discussed.
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