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Keywords {🔍}

doi, pubmed, google, scholar, cell, metabolic, tumor, cancer, cells, growth, kinase, protein, stress, pmc, autophagy, article, free, metabolism, activation, ampk, proliferation, energy, pathways, cellular, glycolysis, regulation, mtor, biol, adaptation, activity, translation, mitochondrial, suppressor, pyruvate, inhibition, function, glucose, cycle, increased, lkb, role, synthesis, acid, signaling, complex, regulates, amino, ampactivated, oxygen, promotes,

Topics {✒️}

endogenous tgf-β-activated kinase-1 amp-activated/snf1 protein kinases anti-apoptotic proteins bcl2/bclxl relieving 4e-bp-mediated inhibition amp-activated protein kinase 5′-amp-activated protein kinase disengaging anti-angiogenic programs phosphatidylinositol 3-kinase-dependent modulation pmc beta search ubiquitin-dependent protein degradation c-myc-dependent glutaminolysis transforming growth factor-β p53-deficient tumors engaged rat acetyl-coa carboxylase c-myc-induced glutaminolysis reinforce ampk-dependent responses mtor-dependent protein translation endoplasmic-reticulum-resident kinase translational inhibitor 4e-bp1 c-myc pathways drives including enhanced β-oxidation oxygen-poor environments subjected p53-dependent feedback loops footnotes article mtor-binding protein raptor akt-dependent mtor activation c-myc proto-oncogene p53-dependent metabolic checkpoint defined tumor suppressors—lkb1 ampk–p53 signaling axis stress-dependent hif1α stabilization ampk-dependent stress responses potent anti-angiogenic factors growth factor-dependent activation citrate-derived acetyl-coa p53-dependent metabolic shift ribosomal s6 kinase cap-binding eif4f complex glucose-dependent atp production pi3k signaling constitute vhl-mediated proteosomal degradation pyruvate-derived acetyl-coa lkb1-ampk-p53 pathway cyclin-dependent kinase tumor suppressors tsc1/tsc2 damage-regulated autophagy modulator tumor suppressor mechanism regulates protein translation growth factor-independent activation hypoxia-induced ros production

Questions {❓}

• The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
• Why do cancers have high aerobic glycolysis?

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• How much income is https://scholar.google.com/scholar_lookup?journal=Nat.%20Cell%20Biol.&title=The%20energy%20sensing%20LKB1-AMPK%20pathway%20regulates%20p27(kip1)%20phosphorylation%20mediating%20the%20decision%20to%20enter%20autophagy%20or%20apoptosis&author=J.%20Liang&author=S.H.%20Shao&author=Z.X.%20Xu&author=B.%20Hennessy&author=Z.%20Ding&volume=9&publication_year=2007&pages=218-224&pmid=17237771&doi=10.1038/ncb1537& earning monthly?
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• How much money does https://doi.org/10.1016/j.molcel.2006.01.010 generate?
• What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Mol.%20Cell&title=Hypoxia-induced%20energy%20stress%20regulates%20mRNA%20translation%20and%20cell%20growth&author=L.%20Liu&author=T.P.%20Cash&author=R.G.%20Jones&author=B.%20Keith&author=C.B.%20Thompson&volume=21&publication_year=2006&pages=521-531&pmid=16483933&doi=10.1016/j.molcel.2006.01.010&?
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• How much income does https://doi.org/10.1038/nrm1660 have?
• See how much https://scholar.google.com/scholar_lookup?journal=Nat.%20Rev.%20Mol.%20Cell%20Biol.&title=Autophagy%20in%20metazoans:%20Cell%20survival%20in%20the%20land%20of%20plenty&author=J.J.%20Lum&author=R.J.%20DeBerardinis&author=C.B.%20Thompson&volume=6&publication_year=2005&pages=439-448&pmid=15928708&doi=10.1038/nrm1660& makes per month
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• See how much https://scholar.google.com/scholar_lookup?journal=Cell&title=Bcl-2%20antiapoptotic%20proteins%20inhibit%20Beclin%201-dependent%20autophagy&author=S.%20Pattingre&author=A.%20Tassa&author=X.%20Qu&author=R.%20Garuti&author=X.H.%20Liang&volume=122&publication_year=2005&pages=927-939&pmid=16179260&doi=10.1016/j.cell.2005.07.002& makes per month
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• Check the income stats for https://doi.org/10.1073/pnas.0308061100
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• See how much https://scholar.google.com/scholar_lookup?journal=Nat.%20Cell%20Biol.&title=Regulation%20of%20autophagy%20by%20cytoplasmic%20p53&author=E.%20Tasdemir&author=M.C.%20Maiuri&author=L.%20Galluzzi&author=I.%20Vitale&author=M.%20Djavaheri-Mergny&volume=10&publication_year=2008b&pages=676-687&pmid=18454141&doi=10.1038/ncb1730& makes per month
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