We are analyzing https://link.springer.com/article/10.1007/s13770-021-00346-z.

Title:
The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis | Tissue Engineering and Regenerative Medicine
Description:
BACKGROUND Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are often resistant to ferroptosis via increased ferritin and impaired ferritinophagy. In this study, we investigated whether treatment with JQ1 could remove senescent cells by inducing ferroptosis. METHODS Senescence of human dermal fibroblasts was induced in vitro by treating the cells with bleomycin. The senolytic effects of JQ1 were evaluated using a SA-β gal assay, annexin V analysis, cell counting kit-8 assay, and qRT-PCR. Ferroptosis following JQ1 treatment was evaluated with qRT-PCR and BODIPY staining. RESULTS At a certain range of JQ1 concentrations, JQ1 treatment reduced the viability of bleomycin-treated cells (senescent cells) but did not reduce that of untreated cells (non-senescent cells), indicating that JQ1 treatment can selectively eliminate senescent cells. JQ1 treatment also decreased SASP expression only in senescent cells. Subsequently, JQ1 treatment reduced the expression of ferroptosis-resistance genes in senescent cells. JQ1 treatment induced lipid peroxidation in senescent cells but not in non-senescent cells. CONCLUSION The data indicate that JQ1 can eliminate senescent cells via ferroptosis. This study suggests ferroptosis as a new mechanism of senolytic therapy.
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pubmed, article, google, scholar, cas, cells, cell, central, ferroptosis, senescent, senescence, kim, cellular, senolytic, death, treatment, wang, aging, med, access, cancer, seoul, tissue, kang, ageing, nat, biol, iron, korea, privacy, cookies, content, research, jeon, byungsoo, human, therapy, protein, disease, data, information, publish, search, engineering, ferritinophagy, study, open, april, stem, inhibition,

Topics {✒️}

ros-activated gcn2-eif2alpha-atf4-xct pathway month download article/chapter magnetic nanoparticle-based approaches adipose-derived stem cells byung‐soo kim sa-β gal assay related subjects iron-dependent form article tissue engineering full article pdf lee tb jr increased brain exposure nonapoptotic cell death cell death dis cell death differ age-related diseases privacy choices/manage cookies iron-dependent yang ws acute myocardial infarction programmed cell senescence locally target therapy national research foundation cellular senescence contributes magnetic cell delivery hee jeon premature cell senescence p53 tumor suppressor ferroptosis-resistance genes alveolar epithelial cells sung pil kwon human dermal fibroblasts eliminate senescent cells senolytic therapy trends cell biol article log european economic area osteogenic differentiation capacity lucke-wold bp blood-brain barrier osteoporotic conditions influence murine ovarian follicles kirkland jl oncogenic ras pro-regenerative environment enhance tissue regeneration optimal wound healing bk21 graduate program animal experiments carried remove senescent cells

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