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  2. Matching Content Categories
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  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
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We are analyzing https://link.springer.com/article/10.1007/s13277-014-2763-6.

Title:
Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma | Tumor Biology
Description:
Esophageal squamous cell carcinoma (ESCC) is one of the prevalent and deadly cancers worldwide, especially in Eastern Asia. The prognosis of ESCC remains poor; thus, it is still necessary to further dissect the underlying mechanisms and explore therapeutic targets of ESCC. Recent studies show that long noncoding RNAs (lncRNAs) have critical roles in diverse biological processes, including tumorigenesis. Some lncRNAs, such as HOTAIR and POU3F3, were reported to play important roles in ESCC. Here, we characterized the expression profile of taurine-upregulated gene 1 (TUG1), a lncRNA recruiting and binding to polycomb repressive complex 2 (PRC2), in ESCC. In a cohort of 62 patients, TUG1 was significantly overexpressed in ESCC tissues compared with paired adjacent normal tissues, and high expression level of TUG1 was associated with family history and upper segment of esophageal cancer (p < 0.05). Further, in vitro silencing TUG1 via siRNA inhibited the proliferation and migration of ESCC cells and blocked the progression of cell cycle. Therefore, our study indicates that TUG1 promotes proliferation and migration of ESCC cells and is a potential oncogene of ESCC.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Photography
  • Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We're unsure how the site profits.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

article, pubmed, google, scholar, cancer, cas, noncoding, long, rna, cell, esophageal, tug, carcinoma, wang, expression, central, squamous, rnas, cells, nanjing, escc, proliferation, yin, lung, research, promotes, migration, qiu, biol, china, hotair, gene, human, int, jiangsu, medical, privacy, cookies, content, biology, access, oesophageal, med, university, information, publish, search, tumor, october, youtao,

Topics {✒️}

month download article/chapter tug1 promotes proliferation short disease-free survival exhibits pro-oncogenic activity rong yin & lin xu coding rna tug1 lung adenocarcinoma-specific long nested case-control study long noncoding rna full article pdf coding rna hotair explore therapeutic targets esophageal adenocarcinoma incidence regulating plk1 expression coding rna metastasis cell death dis diverse biological processes high tug1 expression privacy choices/manage cookies hepatocellular carcinoma progression promote cancer metastasis translational cancer research taurine-upregulated gene 1 lung adenocarcinoma cells long noncoding rnas korean cancer assoc affiliated cancer hospital vitro silencing tug1 exhibits oncogenic activity chromatin-modifying complexes motility-related genes oesophageal adenocarcinoma cells affect gene expression int med res lncrna recruiting nat rev genet affiliated nanjing hospital high expression level gene expression analysis low expression levels jiangsu cancer hospital oesophageal cancer studies natl cancer inst cancer res treat check access instant access complex human diseases related subjects nanjing medical university esophageal cancer

Schema {🗺️}

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         headline:Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma
         description:Esophageal squamous cell carcinoma (ESCC) is one of the prevalent and deadly cancers worldwide, especially in Eastern Asia. The prognosis of ESCC remains poor; thus, it is still necessary to further dissect the underlying mechanisms and explore therapeutic targets of ESCC. Recent studies show that long noncoding RNAs (lncRNAs) have critical roles in diverse biological processes, including tumorigenesis. Some lncRNAs, such as HOTAIR and POU3F3, were reported to play important roles in ESCC. Here, we characterized the expression profile of taurine-upregulated gene 1 (TUG1), a lncRNA recruiting and binding to polycomb repressive complex 2 (PRC2), in ESCC. In a cohort of 62 patients, TUG1 was significantly overexpressed in ESCC tissues compared with paired adjacent normal tissues, and high expression level of TUG1 was associated with family history and upper segment of esophageal cancer (p < 0.05). Further, in vitro silencing TUG1 via siRNA inhibited the proliferation and migration of ESCC cells and blocked the progression of cell cycle. Therefore, our study indicates that TUG1 promotes proliferation and migration of ESCC cells and is a potential oncogene of ESCC.
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            Long noncoding RNA
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            Expression
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      headline:Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma
      description:Esophageal squamous cell carcinoma (ESCC) is one of the prevalent and deadly cancers worldwide, especially in Eastern Asia. The prognosis of ESCC remains poor; thus, it is still necessary to further dissect the underlying mechanisms and explore therapeutic targets of ESCC. Recent studies show that long noncoding RNAs (lncRNAs) have critical roles in diverse biological processes, including tumorigenesis. Some lncRNAs, such as HOTAIR and POU3F3, were reported to play important roles in ESCC. Here, we characterized the expression profile of taurine-upregulated gene 1 (TUG1), a lncRNA recruiting and binding to polycomb repressive complex 2 (PRC2), in ESCC. In a cohort of 62 patients, TUG1 was significantly overexpressed in ESCC tissues compared with paired adjacent normal tissues, and high expression level of TUG1 was associated with family history and upper segment of esophageal cancer (p < 0.05). Further, in vitro silencing TUG1 via siRNA inhibited the proliferation and migration of ESCC cells and blocked the progression of cell cycle. Therefore, our study indicates that TUG1 promotes proliferation and migration of ESCC cells and is a potential oncogene of ESCC.
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         Long noncoding RNA
         Esophageal squamous cell carcinoma
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                  address:
                     name:Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, People’s Republic of China
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                     type:PostalAddress
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            name:Feng Jiang
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                  name:Cancer Institute of Jiangsu Province
                  address:
                     name:Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, People’s Republic of China
                     type:PostalAddress
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            type:Person
            name:Rong Yin
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                  name:Cancer Institute of Jiangsu Province
                  address:
                     name:Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, People’s Republic of China
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            address:
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            address:
               name:Department of Thoracic Surgery, The Affiliated Nanjing Hospital of Nanjing Medical University, Nanjing, China
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               type:PostalAddress
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            name:Cancer Institute of Jiangsu Province
            address:
               name:Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, People’s Republic of China
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            address:
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               type:PostalAddress
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      name:The First Clinical College of Nanjing Medical University, Nanjing, China
      name:Department of Scientific Research, Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing Medical University, Nanjing, China
      name:Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, People’s Republic of China
      name:The Fourth Clinical College of Nanjing Medical University, Nanjing, China
      name:Department of Thoracic Surgery, The Affiliated Nanjing Hospital of Nanjing Medical University, Nanjing, China
      name:Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, People’s Republic of China
      name:Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, People’s Republic of China
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External Links {🔗}(160)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

CDN Services {📦}

  • Crossref

4.43s.