We are analyzing https://link.springer.com/article/10.1007/s12223-018-00670-3.

Title:
Melanoma-related changes in skin microbiome | Folia Microbiologica
Description:
Melanoma is the least common form of skin tumor, but it is potentially the most dangerous and responsible for the majority of skin cancer deaths. We suggest that the skin microbiome might be changed during the progression of melanoma. The aim of this study is to compare the composition of the skin microbiota between different locations (skin and melanoma) of a MeLiM (Melanoma-bearing Libechov Minipig) pig model (exophytic melanoma). Ninety samples were used for PCR-DGGE analysis with primers specifically targeting the V3 region of the 16S rRNA gene. The profiles were used for cluster analysis by UPGMA and principal coordinate analysis PCoA and also to calculate the diversity index (Simpson index of diversity). By comparing the obtained results, we found that both bacterial composition and diversity were significantly different between the skin and melanoma microbiomes. The abundances of Fusobacterium and Trueperella genera were significantly increased in melanoma samples, suggesting a strong relationship between melanoma development and skin microbiome changes.
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Keywords {🔍}

pubmed, article, google, scholar, skin, cas, central, microbiome, cancer, melanoma, czech, fusobacterium, lactobacillus, human, microbiol, analysis, microbiota, access, privacy, cookies, content, nucleatum, colorectal, vitro, cell, sci, httpsdoiorg, zhang, prague, republic, information, journal, publish, search, mrázek, mekadim, progression, pig, model, diversity, clin, segre, staphylococcus, res, disease, nature, httpsdoiorgs, vet, sciences, author,

Topics {✒️}

month download article/chapter genus-specific pcr assay high-altitude living shapes melanoma-bearing libechov minipig vitro anti-metastatic effects full article pdf melanocytic nevi related subjects probiotic lactobacillus reuteri privacy choices/manage cookies 16s rrna gene staphylococcus epidermidis protects human skin microbiome human colorectal carcinoma gastric cancer progression article mrázek pcr-dgge analysis fusobacterium nucleatum infection human infections due superficial spreading melanoma van de veerdonk skin microbiome imbalance immune cell attack hela cell line jitka vlasáková tumor potentiating mechanisms melanoma-related human–microbe mutualism author information authors skin cancer deaths pedunculated malignant melanoma article log european economic area primers specifically targeting mapk signalling pathways mihm mc jr bermúdez-humarán lg louisiana salt marsh network blast server clark wh jr complex microbial populations antimicrobial resistance patterns rare environmental microbes project excellence cz project number lo1609 pancreatic cancer tissues pig skin bacteriome staphylococcus aureus isolated conditions privacy policy trueperella pyogenes infections

Schema {🗺️}

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         description:Melanoma is the least common form of skin tumor, but it is potentially the most dangerous and responsible for the majority of skin cancer deaths. We suggest that the skin microbiome might be changed during the progression of melanoma. The aim of this study is to compare the composition of the skin microbiota between different locations (skin and melanoma) of a MeLiM (Melanoma-bearing Libechov Minipig) pig model (exophytic melanoma). Ninety samples were used for PCR-DGGE analysis with primers specifically targeting the V3 region of the 16S rRNA gene. The profiles were used for cluster analysis by UPGMA and principal coordinate analysis PCoA and also to calculate the diversity index (Simpson index of diversity). By comparing the obtained results, we found that both bacterial composition and diversity were significantly different between the skin and melanoma microbiomes. The abundances of Fusobacterium and Trueperella genera were significantly increased in melanoma samples, suggesting a strong relationship between melanoma development and skin microbiome changes.
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