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Title[redir]:
Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack - PMC
Description:
Bacteria, such as Fusobacterium nucleatum, are present in the tumor microenvironment. However, the immunological consequences of intra-tumoral bacteria remain unclear. Here, we have shown that natural killer (NK) cell killing of various tumors is ...
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Keywords {🔍}
cells, nucleatum, figure, tigit, cell, human, doi, bacteria, incubated, yts, htigit, cytotoxicity, inhibition, tumor, pubmed, google, scholar, fap, binding, pmc, tumors, performed, protein, article, mouse, mutants, observed, stanietsky, strain, free, immune, presence, ratio, assays, primary, killing, strains, pvr, inhibitory, colon, derived, hemagglutination, tils, error, bars, triplicates, receptor, receptors, shows, cti,
Topics {✒️}
modulating e-cadherin/β-catenin signaling mycobacterial adjuvant-based agents fp7-mc-itn-317013-naturimmun pmc beta search bactron i-ii shellab immunodominant tyrosine-based inhibitory cell line-based assays biotinylated anti-human antibodies retinoic acid-inducible gene ur-opathogenic escherichia coli methionine-free media tumor necrosis factor-α tumor-immune evasion mechanism references besser mj nk cell-cytokine secretion primary anti-tigit antibody enhance anti-tumor immunity cell-free supernatants supplementary materials included blocking anti-htigit mab sds page gel primary activating receptor erc advanced grant transposon insertion site european research council nk cell cytotoxicity parental yts eco immune cell attack primary nk cells yts eco kills license information pmcid bei resources repository nk cell activities yts eco killing nk inhibitory receptor human colorectal carcinoma cell death differ fap2-deficient k50 strain elisa-based binding assays yts eco cells yts htigit cytotoxicity control ig-fusion protein tigit-ig fusion protein nk cell receptors nk cell surface nk cell purity tumor cell evasion pp65 overlapping peptides nucleatum undoubtedly possesses helper cell activities
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- Innate or adaptive immunity?
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