We are analyzing https://link.springer.com/article/10.1007/s12032-013-0697-2.

Title:
EMT transcription factors: implication in osteosarcoma | Medical Oncology
Description:
The primary malignant bone tumor, osteosarcoma, is a deadly disorder. Its etiology is complex, and treatment is mostly obscure. The transcription factors (TFs) involved in epithelial to mesenchymal transition (EMT) have significant role in osteosarcoma. A number of evidence suggests that overexpression of EMT-TFs, such as Twist, Snails and Zebs, is involved in complex pathogenesis of osteosarcoma. Recent research studies have showed some extent of promise in osteosarcoma treatment by targeting these EMT-TFs. However, success in research on osteosarcoma-EMT-TFs axis is just in primary stage, and a long way to go. Targeting Twist, Snail or Zeb by specific molecules or chemotherapeutic agents may provide a new dimension in osteosarcoma treatment by controlling metastasis.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter transcription factor nf-kappab dna damage-induced apoptosis jian yuan & kanghua li epithelial-mesenchymal transition variable beta-catenin expression pi3k/akt/mtor axis represses nf-kappab activity epithelial-mesenchymal transitions transcription factor snail epithelial tumour cells cancer stem cells transcription factor twist1 repressing e-cadherin expression mesenchymal/epithelial plasticity β-catenin signaling zeb transcription factors emt transcription factors central south university e-cadherin gene expression full article pdf mesenchymal transition mesenchymal transition osteosarcoma-emt-tfs axis stem cells recent research studies privacy choices/manage cookies snail/slug family transcription factors man tk mani sa sayan ae murine osteosarcoma cells cancer treat res mol cancer res e-cadherin downregulation canine mammary sarcomas caron de fromentel garcía de herreros pérez-moreno ma osteosarcoma cells [abstract] emt-linked loss dna cell biol treat colon cancer european economic area end results program ferguson ws semin pediatr surg kunz-schughart la del barrio mg

Questions {❓}

Cancer stem cells and epithelial-to-mesenchymal transition (EMT)-phenotypic cells: are they cousins or twins?
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

Schema {🗺️}

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