We are analyzing https://link.springer.com/article/10.1007/s11427-017-9046-6.

Title:
Targeting sphingosine-1-phosphate signaling for cancer therapy | Science China Life Sciences
Description:
Sphingosine-1-phosphate (S1P) is a potent pleotropic bioactive lipid mediator involved in immune cell trafficking, cell survival, cell proliferation, cell migration, angiogenesis and many other cellular processes. S1P either activates S1P receptors (S1PR1-5) through “inside-out signaling” or acts directly on intracellular targets to regulate various cellular processes. In the past two decades, much progress has been made in exploring S1P signaling and its pathogenic roles in diseases as well as in developing modulators of S1P signaling, including S1P agonists, S1P antagonists and sphingosine kinase (SphK) inhibitors. Ceramide and S1P have been defined as reciprocal regulators of cell fate, and S1P signaling has been shown to be crucial for the pathogenesis of various diseases, including autoimmune diseases, inflammation and cancer; therefore, targeting S1P signaling may curtail the process of pathogenesis and serve as a potential therapeutic target for the treatment of these diseases. In this review, we describe recent advances in our understanding of S1P signaling in cancer development (particularly in inflammation- associated cancer) as well as in innate and adaptive immunity, and we also discuss modulators of S1P signaling in cancer treatment.
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Keywords {🔍}

pubmed, google, scholar, article, cas, sphingosine, cancer, central, cell, kinase, receptor, sphingosinephosphate, cells, phosphate, signaling, biol, spiegel, chem, res, pyne, liu, milstien, human, immunol, wang, growth, inhibitor, receptors, lee, zhang, expression, chen, fty, survival, smith, activation, biochem, nat, targeting, tumor, faseb, pharmacol, drug, med, ceramide, development, hait, inhibition, ther, regulates,

Topics {✒️}

il6/stat3/socs3 signalling pathway t-bet-dependent s1p5 expression g-protein-coupled receptor related targeting g-protein-coupled receptors sphingosine-1-phosphate promotes expansion month download article/chapter sphingosine 1-phosphate signalling pathway involving c-src pi3-kinase-akt pathway ceramide-induced mitochondrial apoptosis g-protein-coupled receptors oxidative stress-dependent mechanism doxorubicin-induced dna damage sphingosine-1-phosphate receptor-3 signaling china life sci intracellular bcl-2/bax rheostat ligand-independent notch activation targeting sphingosine-1-phosphate signaling gp130-mediated stat3 activation sphingosine 1-phosphate-induced autophagy pdgf-induced cell motility attenuates chronic rejection sphingosine-1-phosphate receptor edg-1 sphingosine-1-phosphate receptor s1p1 targeting sphingosine-1-phosphate receptors interleukin-10 gene-deficient mice stat3-induced s1pr1 expression s1p3-mediated akt activation colitis-driven colon cancer pp2a-ripk1-dependent necroptosis mitogen-activated protein kinases alpha i-coupled receptors central nervous system extracellular signal-regulated kinase-1/2 relapsing-remitting multiple sclerosis gsk-3beta acts downstream full article pdf transgenic constitutive expression reciprocal erk-dependent suppression prolongs graft survival protein-coupled receptor protein- coupled receptor sphingosine 1-phosphate receptor-1 sphingosine-1-phosphate receptor 1 sphingosine-1-phosphate receptor 2 sphingosine-1-phosphate receptor 3 pi-3k/akt induces growth arrest differentiating stem cells biologically active sphingolipids

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      description:Sphingosine-1-phosphate (S1P) is a potent pleotropic bioactive lipid mediator involved in immune cell trafficking, cell survival, cell proliferation, cell migration, angiogenesis and many other cellular processes. S1P either activates S1P receptors (S1PR1-5) through “inside-out signaling” or acts directly on intracellular targets to regulate various cellular processes. In the past two decades, much progress has been made in exploring S1P signaling and its pathogenic roles in diseases as well as in developing modulators of S1P signaling, including S1P agonists, S1P antagonists and sphingosine kinase (SphK) inhibitors. Ceramide and S1P have been defined as reciprocal regulators of cell fate, and S1P signaling has been shown to be crucial for the pathogenesis of various diseases, including autoimmune diseases, inflammation and cancer; therefore, targeting S1P signaling may curtail the process of pathogenesis and serve as a potential therapeutic target for the treatment of these diseases. In this review, we describe recent advances in our understanding of S1P signaling in cancer development (particularly in inflammation- associated cancer) as well as in innate and adaptive immunity, and we also discuss modulators of S1P signaling in cancer treatment.
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