We are analyzing https://link.springer.com/article/10.1007/s10555-020-09925-3.

Title:
Gastric cancer: a comprehensive review of current and future treatment strategies | Cancer and Metastasis Reviews
Description:
Gastric cancer remains a major unmet clinical problem with over 1 million new cases worldwide. It is the fourth most commonly occurring cancer in men and the seventh most commonly occurring cancer in women. A major fraction of gastric cancer has been linked to variety of pathogenic infections including but not limited to Helicobacter pylori (H. pylori) or Epstein Barr virus (EBV). Strategies are being pursued to prevent gastric cancer development such as H. pylori eradication, which has helped to prevent significant proportion of gastric cancer. Today, treatments have helped to manage this disease and the 5-year survival for stage IA and IB tumors treated with surgery are between 60 and 80%. However, patients with stage III tumors undergoing surgery have a dismal 5-year survival rate between 18 and 50% depending on the dataset. These figures indicate the need for more effective molecularly driven treatment strategies. This review discusses the molecular profile of gastric tumors, the success, and challenges with available therapeutic targets along with newer biomarkers and emerging targets.
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Keywords {🔍}

cancer, pubmed, article, google, scholar, gastric, cas, central, journal, zhang, wang, clinical, autophagy, chen, liu, oncology, patients, cells, cell, research, httpsdoiorgs, kim, doi, advanced, phase, molecular, yang, expression, pylori, httpsdoiorg, human, huang, international, lee, tumor, therapy, adenocarcinoma, gastroenterology, chemotherapy, treatment, helicobacter, trial, disease, metastasis, zhou, lin, signaling, review, randomized, zhu,

Topics {✒️}

month download article/chapter epstein-barr virus-negative carcinoma small molecule inhibitor org/professionals/physician_gls/pdf/gastric dnm1l-mediated mitochondrial fission jak2/stat3 signaling pathway transcriptome-wide pirna profiling selective dna-pk inhibitor pi3k/akt/mtor pathway beclin-1vsp34 complex architecture tissue/site agnostic indication gastro-oesophageal junction cancer gastro-oesophageal junction adenocarcinoma epstein barr virus epstein-barr virus her2-positive advanced gastric sphingobium yanoikuyae b1 phase i-ii study overcome stroma-induced resistance wogonin induces beclin-1/pi3k b-cell fusion diffuse-type gastric cancer full article pdf gremlin1 promotes proliferation potential anti-tumor agents activated fibroblasts mediated epithelial mesenchymal transition akt1 signaling pathway reactive oxygen species mitochondrial ros generation fgfr inhibitor azd4547 stromal-based signatures iii gastric cancer privacy choices/manage cookies class iii pi3ks epithelial cell fusion phase 3 open-label experimental cell research oxidative stress responses low-dose paclitaxel high-temperature beverages mct-hifa signaling ib tumors treated fluorouracil versus fluorouracil human gastric cancer promotes tumor growth human pancreatic cells resectable esophagogastric cancer resectable esophagogastric adenocarcinoma human wound infections

Questions {❓}

Helicobacter pylori: a true carcinogen?
Sizing up long non-coding RNAs do lncRNAs have secondary and tertiary structure?

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            Non coding RNAs
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         Non coding RNAs
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         Piwi RNA
         Autophagy
         Novel targets
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         general
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