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Keywords {🔍}

pirnas, cancer, expression, gastric, pubmed, analysis, article, pirna, google, scholar, rnas, nonmalignant, expressed, stomach, rfs, cas, survival, tissue, fig, data, significantly, piwiinteracting, adenocarcinoma, small, samples, signature, values, noncoding, rna, logrank, risk, research, performed, clustering, central, information, atlas, high, cohort, tcga, table, utility, recurrence, identified, clinical, types, genome, copy, number, additional,

Topics {✒️}

called piwi-interacting rnas small-cell lung cancer average fold change piwi-pirna pathway piwi-interacting rnas 312 piwi-interacting rnas 156 piwi-interacting rnas log-rank survival analysis genome-wide expression patterns cox proportional hazard full size image org/cancer/software/gene expression fold change privacy choices/manage cookies coding small rna unsupervised hierarchical clustering rank normalized prior ga patient outcome gastric adenocarcinoma highlights suggesting conserved importance 16 months [hazard ratio 10 dna copy number rank-normalized expression gastric cancer genome raw sequencing data consensus clustering analysis copy number status asian gastric cancer clustering algorithm = hierarchical gastric adenocarcinoma samples long noncoding rnas gastric cancer recurrence cancer types selected coding rnas mirnas circulating tumor cells kaplan–meier analysis dna-level mechanisms malignant stomach tissue recurrence-free survival protein-coding sequences protein-coding transcripts copy number alterations custom analysis pipeline log-rank method cancer genome atlas human cancer cells cancer gene ther european economic area million mapped reads outermost rings represent

Schema {🗺️}

WebPage:
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         headline:An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence
         description:The poor survival and recurrence rate in gastric adenocarcinoma highlights the need for cancer gene discovery. Towards this end, we globally assessed the expression of an emerging class of small non-coding RNAs, called PIWI-interacting RNAs (piRNAs). We analysed the transcriptomes of 358 non-malignant stomach tissue and gastric adenocarcinoma samples, and found that nearly half of the expressed piRNAs were overexpressed in tumours. Our gastric piRNA atlas showed that most piRNAs were embedded in protein-coding sequences rather than known piRNA clusters. Furthermore, we identified a three-piRNA signature associated with recurrence-free survival. In this proof-of-principle study, we demonstrate the potential clinical utility of piRNAs in gastric cancer.
         datePublished:2015-03-17T00:00:00Z
         dateModified:2015-03-17T00:00:00Z
         pageStart:660
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         keywords:
            PIWI-interacting RNAs
            Epigenetics
            PIWI
            Gastric adenocarcinoma
            Patient outcome
            Surgical Oncology
            Oncology
            Abdominal Surgery
            Gastroenterology
            Cancer Research
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      headline:An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence
      description:The poor survival and recurrence rate in gastric adenocarcinoma highlights the need for cancer gene discovery. Towards this end, we globally assessed the expression of an emerging class of small non-coding RNAs, called PIWI-interacting RNAs (piRNAs). We analysed the transcriptomes of 358 non-malignant stomach tissue and gastric adenocarcinoma samples, and found that nearly half of the expressed piRNAs were overexpressed in tumours. Our gastric piRNA atlas showed that most piRNAs were embedded in protein-coding sequences rather than known piRNA clusters. Furthermore, we identified a three-piRNA signature associated with recurrence-free survival. In this proof-of-principle study, we demonstrate the potential clinical utility of piRNAs in gastric cancer.
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      dateModified:2015-03-17T00:00:00Z
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      keywords:
         PIWI-interacting RNAs
         Epigenetics
         PIWI
         Gastric adenocarcinoma
         Patient outcome
         Surgical Oncology
         Oncology
         Abdominal Surgery
         Gastroenterology
         Cancer Research
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               type:PostalAddress
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            address:
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      name:Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, Canada

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