We are analyzing https://link.springer.com/article/10.1007/s10549-011-1422-5.

Title:
Molecular and epidemiological characteristics of inflammatory breast cancer in Algerian patients | Breast Cancer Research and Treatment
Description:
Inflammatory breast cancer (IBC) shows a high incidence in Tunisia and Egypt but epidemiological and molecular characteristics have not been described in Algeria. We compared 117 IBC and 59 non-IBC locally advanced breast cancers (LABC), for estrogen and progesterone receptors, HER2, and EGFR protein expression by immunohistochemistry, and HER2 gene amplification by chromogenic in situ hybridization. Demographic, clinico-pathological, and molecular variables were compared with chi-square and Fisher’s exact tests to test for significance (P < 0.05, two-tailed). Overall survival (OS) and disease-free survival (DFS) were plotted using Kaplan–Meier curves and compared using the log-rank test. Tumor emboli were detected in 77% of IBC. Palpable masses were found in all LABC but only in 32% of IBC (P < 0.001). Recurrences were higher in LABC than in IBC (48 vs. 35%; P = 0.14) but OS was worse in IBC (68 vs. 71%; P = 0.06). There were no significant differences between IBC and LABC by demographics or by clinico-pathological parameters. The majority of IBC and LABC tumors were luminal A (62 and 64%), followed by basal (~18%, each), triple negative (~18%, each), and HER2+ (~10%, each) subtypes. In multivariate analyses, grade was associated with worse OS (P = 0.04), and DFS (P < 0.001) in IBC; chemo- and radio-therapy were associated with improved OS and DFS, respectively (P < 0.05 for each) in LABC. In conclusion, IBC in Algeria shows similar characteristics to IBC described for Egypt and Tunisia with subtle molecular differences. Current therapeutic treatments were not very effective in this population and new approaches are much needed.
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cancer, breast, article, inflammatory, google, scholar, pubmed, cas, ibc, oncol, study, patients, survival, molecular, clinical, ben, research, treatment, tunisia, cancers, labc, tumor, levine, mexico, privacy, cookies, content, information, ariaspulido, algeria, advanced, access, van, clin, data, publish, search, characteristics, chaher, marie, egypt, locally, expression, emboli, similar, merajver, banerjee, hablas, omar, res,

Topics {✒️}

month download article/chapter population-based cancer registry french-tunisian joint study progesterone receptors tumor emboli breast tumor markers parallel her2-negative cohort dermal lymphatic emboli inflammatory breast cancers inflammatory breast cancers full article pdf inflammatory breast cancer inflammatory breast cancer hugo arias-pulido breast cancer similar privacy choices/manage cookies breast cancer incidence noninflammatory breast cancer inflammatory carcinoma breast epithelial ovarian cancers melanie royce international expert panel national cancer institute mexico cancer center progesterone receptor status unique clinical experience human tissue repository bmc cancer 8 case control study phase ii study disease-free survival expanded her2+ cohort van der auwera egfr protein expression article chaher european economic area her2 gene amplification kaplan–meier curves current therapeutic treatments related subjects 1093/annonc/mdq345 molckovsky body mass index dermal lymphatic invasion predictive biomarker profiles her2-overexpressing relapsed uicc icrett fellowship medical oncology conditions privacy policy urban–rural differences end results program

Questions {❓}

Lê MG, Arriagada R, Bahi J, Pfeiffer F, Cammoun M, Tabbane F, Rubino C (2006) Are risk factors for breast cancer similar in women with inflammatory breast cancer and in those with non-inflammatory breast cancer?

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         headline:Molecular and epidemiological characteristics of inflammatory breast cancer in Algerian patients
         description:Inflammatory breast cancer (IBC) shows a high incidence in Tunisia and Egypt but epidemiological and molecular characteristics have not been described in Algeria. We compared 117 IBC and 59 non-IBC locally advanced breast cancers (LABC), for estrogen and progesterone receptors, HER2, and EGFR protein expression by immunohistochemistry, and HER2 gene amplification by chromogenic in situ hybridization. Demographic, clinico-pathological, and molecular variables were compared with chi-square and Fisher’s exact tests to test for significance (P < 0.05, two-tailed). Overall survival (OS) and disease-free survival (DFS) were plotted using Kaplan–Meier curves and compared using the log-rank test. Tumor emboli were detected in 77% of IBC. Palpable masses were found in all LABC but only in 32% of IBC (P < 0.001). Recurrences were higher in LABC than in IBC (48 vs. 35%; P = 0.14) but OS was worse in IBC (68 vs. 71%; P = 0.06). There were no significant differences between IBC and LABC by demographics or by clinico-pathological parameters. The majority of IBC and LABC tumors were luminal A (62 and 64%), followed by basal (~18%, each), triple negative (~18%, each), and HER2+ (~10%, each) subtypes. In multivariate analyses, grade was associated with worse OS (P = 0.04), and DFS (P < 0.001) in IBC; chemo- and radio-therapy were associated with improved OS and DFS, respectively (P < 0.05 for each) in LABC. In conclusion, IBC in Algeria shows similar characteristics to IBC described for Egypt and Tunisia with subtle molecular differences. Current therapeutic treatments were not very effective in this population and new approaches are much needed.
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            Locally advanced breast cancer
            Tumor emboli
            Tumor subtypes
            Hormone receptors
            Growth factor receptors
            Overall survival
            Disease-free survival
            Oncology
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      headline:Molecular and epidemiological characteristics of inflammatory breast cancer in Algerian patients
      description:Inflammatory breast cancer (IBC) shows a high incidence in Tunisia and Egypt but epidemiological and molecular characteristics have not been described in Algeria. We compared 117 IBC and 59 non-IBC locally advanced breast cancers (LABC), for estrogen and progesterone receptors, HER2, and EGFR protein expression by immunohistochemistry, and HER2 gene amplification by chromogenic in situ hybridization. Demographic, clinico-pathological, and molecular variables were compared with chi-square and Fisher’s exact tests to test for significance (P < 0.05, two-tailed). Overall survival (OS) and disease-free survival (DFS) were plotted using Kaplan–Meier curves and compared using the log-rank test. Tumor emboli were detected in 77% of IBC. Palpable masses were found in all LABC but only in 32% of IBC (P < 0.001). Recurrences were higher in LABC than in IBC (48 vs. 35%; P = 0.14) but OS was worse in IBC (68 vs. 71%; P = 0.06). There were no significant differences between IBC and LABC by demographics or by clinico-pathological parameters. The majority of IBC and LABC tumors were luminal A (62 and 64%), followed by basal (~18%, each), triple negative (~18%, each), and HER2+ (~10%, each) subtypes. In multivariate analyses, grade was associated with worse OS (P = 0.04), and DFS (P < 0.001) in IBC; chemo- and radio-therapy were associated with improved OS and DFS, respectively (P < 0.05 for each) in LABC. In conclusion, IBC in Algeria shows similar characteristics to IBC described for Egypt and Tunisia with subtle molecular differences. Current therapeutic treatments were not very effective in this population and new approaches are much needed.
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      dateModified:2011-03-01T00:00:00Z
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         Inflammatory breast cancer
         Locally advanced breast cancer
         Tumor emboli
         Tumor subtypes
         Hormone receptors
         Growth factor receptors
         Overall survival
         Disease-free survival
         Oncology
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