We are analyzing https://link.springer.com/article/10.1007/s10803-006-0134-x.

Title:
Utilization of Lymphoblastoid Cell Lines as a System for the Molecular Modeling of Autism | Journal of Autism and Developmental Disorders
Description:
In order to provide an alternative approach for understanding the biology and genetics of autism, we performed statistical analysis of gene expression profiles of lymphoblastoid cell lines derived from children with autism and their families. The goal was to assess the feasibility of using this model in identifying autism-associated genes. Replicate microarray experiments demonstrated that expression data from the cell lines were consistent and highly reproducible. Further analyses identified differentially expressed genes between cell lines derived from children with autism and those derived from their normally developing siblings. These genes were then used to identify biochemical pathways potentially involved in autism. This study suggests that lymphoblastoid cell lines may be a viable tool for identifying genes associated with autism.
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Keywords {🔍}

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Topics {✒️}

loading [mathjax]/jax/output/html-css/config privacy choices/manage cookies author information authors additional information world health organization lymphoblastoid cell lines gene expression data gene expression profiles asd gene expression gene expression surveyed �open label” evaluation full article pdf autism diagnostic interview-revised cerebral blood flow cell lines derived gene regulatory networks conditions privacy policy single cell data agre cell lines nucleic acids research breast cancer research providing cells lines genetic risk factor web-based resource double-blind comparison impaired feedback regulation bootstrapping cluster analysis focal cerebral ischemia latent-class analysis acta neurologica scandinavica adjacent breast tumors zeljka smit-mcbride support cancel contracts gene expression strongly genetic disorder performed statistical analysis related neuropsychiatric conditions postmortem brain abnormalities ten candidate genes common molecular signature author correspondence developmental disorders aims pervasive developmental disorders autism diagnostic interview family history study liu contributed equally autism susceptibility loci autism-susceptibility loci cell lines check access

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         description:In order to provide an alternative approach for understanding the biology and genetics of autism, we performed statistical analysis of gene expression profiles of lymphoblastoid cell lines derived from children with autism and their families. The goal was to assess the feasibility of using this model in identifying autism-associated genes. Replicate microarray experiments demonstrated that expression data from the cell lines were consistent and highly reproducible. Further analyses identified differentially expressed genes between cell lines derived from children with autism and those derived from their normally developing siblings. These genes were then used to identify biochemical pathways potentially involved in autism. This study suggests that lymphoblastoid cell lines may be a viable tool for identifying genes associated with autism.
         datePublished:2006-07-15T00:00:00Z
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      headline:Utilization of Lymphoblastoid Cell Lines as a System for the Molecular Modeling of Autism
      description:In order to provide an alternative approach for understanding the biology and genetics of autism, we performed statistical analysis of gene expression profiles of lymphoblastoid cell lines derived from children with autism and their families. The goal was to assess the feasibility of using this model in identifying autism-associated genes. Replicate microarray experiments demonstrated that expression data from the cell lines were consistent and highly reproducible. Further analyses identified differentially expressed genes between cell lines derived from children with autism and those derived from their normally developing siblings. These genes were then used to identify biochemical pathways potentially involved in autism. This study suggests that lymphoblastoid cell lines may be a viable tool for identifying genes associated with autism.
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