We are analyzing https://link.springer.com/article/10.1007/s10067-018-4080-8.

Title:
Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study | Clinical Rheumatology
Description:
Resveratrol (RSV), a naturally occurring polyphenol, has been found to have potent antioxidant, anti-inflammatory, and anticancer effects. Recently, RSV was reported as a new potential agent to suppress inflammation of collagen-induced arthritis in a mouse model. Nevertheless, the clinical benefits of RSV in the management of rheumatoid arthritis (RA) were not studied. This randomized controlled clinical trial aims to shed some light on the therapeutic benefits of RSV in the treatment of RA in patients with different stages of the disease activity. In this randomized controlled clinical trial, 100 RA patients (68 female, 32 male) were enrolled randomly and divided into two groups, each of 50 patients: an RSV-treated group that received a daily RSV capsule of 1 g with the conventional treatment for 3 months and a control group that just received the regular treatment. The clinical and biochemical markers of RA in both groups were assessed. It was found that the clinical markers (i.e., the 28-joint count for swelling and tenderness) and the disease activity score assessment for 28 joints were significantly lowered in the RSV-treated group. Moreover, serum levels of certain biochemical markers (i.e., C-reactive protein, erythrocyte sedimentation rate, undercarboxylated osteocalcin, matrix metalloproteinase-3, tumor necrosis factor alpha, and interleukin-6) were also significantly decreased in RSV-treated patients. The current study suggests the addition of RSV as an adjuvant to the conventional antirheumatic drugs.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

article, pubmed, google, scholar, arthritis, cas, resveratrol, rheumatoid, clinical, study, trial, patients, disease, university, assiut, treatment, serum, rheum, central, research, rsv, randomized, factor, access, privacy, cookies, content, data, rheumatology, ahmed, activity, httpsdoiorgs, safety, res, department, publish, search, adjuvant, therapy, management, khojah, abdelrahman, effects, received, levels, tumor, necrosis, dis, supplementation, placebocontrolled,

Topics {✒️}

month download article/chapter randomised placebo-controlled trial placebo-controlled pilot study rising multiple-dose study c-reactive protein resveratrol-induced apoptosis high-dose resveratrol treatment full article pdf abdel-rahman department collagen-induced arthritis vaz-da-silva abdel-rahman & eman eular response criteria privacy choices/manage cookies randomized clinical trial effective adjuvant therapy rheumatoid arthritis patients soares-da-silva biological treatment randomised clinical trial rheumatoid arthritis pathogenesis tnf-alpha disease activity score randomized clinical trials reactive oxygen species valuable prognostic factor growth factor axis 1093/rheumatology/kes113 saxne large observational cohort repeat dose study peripheral artery disease european economic area naturally occurring polyphenol erythrocyte sedimentation rate enable decision making related subjects palladino ma jr sirtuin 1-dependent manner plga nanoparticulate formulation van riel pl anton sd double-blind antigenic keratan sulfate abdel-rahman resveratrol improves efficacy institutional review board conditions privacy policy current study suggests placebo-controlled check access

Questions {❓}

Novelle MG, Wahl D, Dieguez C, Bernier M, de Cabo R (2015) Resveratrol supplementation: where are we now and where should we go?

Schema {🗺️}

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