We are analyzing https://link.springer.com/article/10.1007/s00436-014-4094-3.

Title:
Besnoitia besnoiti tachyzoites induce monocyte extracellular trap formation | Parasitology Research
Description:
Extracellular trap (ET) formation has been demonstrated as an important novel effector mechanism of polymorphonuclear neutrophils (PMN), eosinophils, mast cells and macrophages acting extracellularly against pathogens. In the present study, we show that tachyzoites of the emerging apicomplexan parasite Besnoitia besnoiti, that have recently been reported as potent inducers of PMN-derived ETosis, also trigger the release of ETs in an additional cell type, namely in monocytes. Fluorescence illustrations as well as scanning electron microscopy analyses (SEM) showed monocyte-promoted ET formation to be rapidly induced upon exposure to viable tachyzoites of B. besnoiti. Classical characteristics of ETs were confirmed by the co-localization of extracellular DNA with histones (H3) or myeloperoxidase (MPO) in parasite-entrapping structures. Monocyte-derived ETs were efficiently abolished by DNase I treatment and significantly reduced by treatments with inhibitors of MPO and NADPH oxidase, thus strengthening the key roles of reactive oxygen species (ROS) and MPO in monocyte ET formation. For comparative reasons, we additionally tested sporozoite stages of the closely related parasite Eimeria bovis for their capacity to induce monocyte-derived ETs and showed that these stages indeed induce ETs. To our best knowledge, we here report for the first time on monocyte ETs against the apicomplexan parasites B. besnoiti and E. bovis. Our results indicate that monocyte-triggered ETs may represent an important effector mechanism of the host early innate immune response against B. besnoiti and add a new cell type to the list of cells capable to release ETs.
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Keywords {🔍}

article, pubmed, google, scholar, cas, extracellular, parasitol, besnoiti, besnoitia, formation, traps, neutrophil, bovine, trap, hermosilla, cell, taubert, eimeria, bovis, central, besnoitiosis, ets, immune, vet, monocyte, response, access, immunol, schares, induce, muñozcaro, silva, neutrophils, cells, parasite, release, innate, cattle, res, privacy, cookies, content, research, parasitology, macrophages, apicomplexan, zahner, isolation, journal, publish,

Topics {✒️}

month download article/chapter induce monocyte-derived ets parasite-host cell interactions extracellular trap formation cross-sectional serological survey anja taubert & carlos hermosilla macrophage-mediated immune reactions macrophage extracellular trap b-lymphocyte-deficient animals phagocytosis-independent antimicrobial activity madin-darby bovine kidney neutrophil extracellular traps article muñoz-caro toxoplasma-infected human monocytes fluidic shear stress phagocyte extracellular traps full article pdf central-eastern europe innate immune reactions monocyte-derived ets privacy choices/manage cookies innate immune reaction macrophages acting extracellularly early tissue cysts pmn-derived etosis parasite-entrapping structures viable tachyzoites justus liebig university harker ks adaptive immune response monocyte-triggered ets human monocyte adhesion showed monocyte-promoted viable coccidial sporozoites besnoitia besnoiti chronically infected cow toxoplasma gondii modulates toxoplasma gondii antigens electron microscopical study european economic area vila-vicosa mj gollnick ns anti-parasitic defence behrendt jh central europa article log naturally infected bull conditions privacy policy reactive oxygen species exogenous nitrogen species

Questions {❓}

Brinkmann V, Zychlinsky A (2012) Neutrophil extracellular traps: is immunity the second function of chromatin?

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         description:Extracellular trap (ET) formation has been demonstrated as an important novel effector mechanism of polymorphonuclear neutrophils (PMN), eosinophils, mast cells and macrophages acting extracellularly against pathogens. In the present study, we show that tachyzoites of the emerging apicomplexan parasite Besnoitia besnoiti, that have recently been reported as potent inducers of PMN-derived ETosis, also trigger the release of ETs in an additional cell type, namely in monocytes. Fluorescence illustrations as well as scanning electron microscopy analyses (SEM) showed monocyte-promoted ET formation to be rapidly induced upon exposure to viable tachyzoites of B. besnoiti. Classical characteristics of ETs were confirmed by the co-localization of extracellular DNA with histones (H3) or myeloperoxidase (MPO) in parasite-entrapping structures. Monocyte-derived ETs were efficiently abolished by DNase I treatment and significantly reduced by treatments with inhibitors of MPO and NADPH oxidase, thus strengthening the key roles of reactive oxygen species (ROS) and MPO in monocyte ET formation. For comparative reasons, we additionally tested sporozoite stages of the closely related parasite Eimeria bovis for their capacity to induce monocyte-derived ETs and showed that these stages indeed induce ETs. To our best knowledge, we here report for the first time on monocyte ETs against the apicomplexan parasites B. besnoiti and E. bovis. Our results indicate that monocyte-triggered ETs may represent an important effector mechanism of the host early innate immune response against B. besnoiti and add a new cell type to the list of cells capable to release ETs.
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      headline:Besnoitia besnoiti tachyzoites induce monocyte extracellular trap formation
      description:Extracellular trap (ET) formation has been demonstrated as an important novel effector mechanism of polymorphonuclear neutrophils (PMN), eosinophils, mast cells and macrophages acting extracellularly against pathogens. In the present study, we show that tachyzoites of the emerging apicomplexan parasite Besnoitia besnoiti, that have recently been reported as potent inducers of PMN-derived ETosis, also trigger the release of ETs in an additional cell type, namely in monocytes. Fluorescence illustrations as well as scanning electron microscopy analyses (SEM) showed monocyte-promoted ET formation to be rapidly induced upon exposure to viable tachyzoites of B. besnoiti. Classical characteristics of ETs were confirmed by the co-localization of extracellular DNA with histones (H3) or myeloperoxidase (MPO) in parasite-entrapping structures. Monocyte-derived ETs were efficiently abolished by DNase I treatment and significantly reduced by treatments with inhibitors of MPO and NADPH oxidase, thus strengthening the key roles of reactive oxygen species (ROS) and MPO in monocyte ET formation. For comparative reasons, we additionally tested sporozoite stages of the closely related parasite Eimeria bovis for their capacity to induce monocyte-derived ETs and showed that these stages indeed induce ETs. To our best knowledge, we here report for the first time on monocyte ETs against the apicomplexan parasites B. besnoiti and E. bovis. Our results indicate that monocyte-triggered ETs may represent an important effector mechanism of the host early innate immune response against B. besnoiti and add a new cell type to the list of cells capable to release ETs.
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