We are analyzing https://link.springer.com/article/10.1007/s00428-018-2297-1.

Title:
High immune cell score predicts improved survival in pancreatic cancer | Virchows Archiv
Description:
Increasing evidence suggests that cancer progression is strongly influenced by host immune response, which is represented by immune cell infiltrates. T-lymphocyte-based immunoscore has proved to be a prognostic factor in colon cancer, but its significance in pancreatic cancer is poorly known. Total of 108 patients operated (R0/R1) for pancreatic ductal adenocarcinoma (PDAC) (TNM stage I–II) were included in the study. Immune cell score (IS) was determined by scoring the samples from grade 0 to 4 according to the number of immune cells (CD3+ and CD8+) in tumor core and invasion margin using tissue microarrays, immunohistochemistry, and digital analysis. Tumors with microsatellite instability were identified by MLH1 immunostaining. High IS and low histological grade were significantly associated with better disease-specific survival (DSS) and overall survival (OS). The 5-year DSS rate for low, moderate, and high IS groups were 5.0, 15.2, and 33.4%, respectively (p = 0.007). The 5-year OS rate for the low, moderate, and high IS groups were 4.2, 13.4, and 31.5%, respectively (p = 0.004). In addition, IS and prognosis varied within a single TNM stage. There was no association between IS and any of the clinicopathological variables. IS was shown to be an independent prognostic factor for better DSS and OS in multivariate analysis, together with the histological grade of the tumor and perineural invasion. Five MLH1-negative tumors (4.6%) were found showing no correlation with IS. IS could be a useful prognostic marker in patients with PDAC treated by primary surgery.
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Keywords {🔍}

pubmed, article, cancer, google, scholar, pancreatic, central, cas, immune, survival, adenocarcinoma, cell, ductal, patients, surg, research, prognostic, microsatellite, instability, wang, finland, cells, ann, score, immunoscore, access, privacy, cookies, content, analysis, high, wirta, prognosis, microenvironment, httpsdoiorg, clin, res, author, hospital, oulu, data, publish, search, virchows, pages, tahkola, mecklin, kellokumpu, tumor, dss,

Topics {✒️}

erkki-ville wirta month download article/chapter immune cell score cd4+ tumor-infiltrating lymphocytes cd8+ tumor-infiltrating lymphocytes t-lymphocyte-based immunoscore immune cell infiltrates disease-specific survival immune cell infiltration pancreatic cancer microenvironment full article pdf jukka-pekka mecklin related subjects widespread microsatellite instability mast cell count state research funding tumor-infiltrating regulatory host immune response immune microenvironment privacy choices/manage cookies pancreas cancer microenvironment pancreatic ductal adenocarcinoma pancreatic cancer—comparison resectable pancreatic cancer check access instant access long-term survival american joint committee article tahkola colorectal cancer prognosis correa de sampaio finnish cancer foundation author correspondence oulu university hospital tumor microenvironment deficient colon cancer article log european economic area microsatellite instability iacobuzio-donahue ca o'donnell-tormey worldwide task force mismatch repair-proficient american joint commission aatos erkko foundation finnish national authority conditions privacy policy independent prognostic factor invasive ductal carcinoma unknown primary abbreviations

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         headline:High immune cell score predicts improved survival in pancreatic cancer
         description:Increasing evidence suggests that cancer progression is strongly influenced by host immune response, which is represented by immune cell infiltrates. T-lymphocyte-based immunoscore has proved to be a prognostic factor in colon cancer, but its significance in pancreatic cancer is poorly known. Total of 108 patients operated (R0/R1) for pancreatic ductal adenocarcinoma (PDAC) (TNM stage I–II) were included in the study. Immune cell score (IS) was determined by scoring the samples from grade 0 to 4 according to the number of immune cells (CD3+ and CD8+) in tumor core and invasion margin using tissue microarrays, immunohistochemistry, and digital analysis. Tumors with microsatellite instability were identified by MLH1 immunostaining. High IS and low histological grade were significantly associated with better disease-specific survival (DSS) and overall survival (OS). The 5-year DSS rate for low, moderate, and high IS groups were 5.0, 15.2, and 33.4%, respectively (p = 0.007). The 5-year OS rate for the low, moderate, and high IS groups were 4.2, 13.4, and 31.5%, respectively (p = 0.004). In addition, IS and prognosis varied within a single TNM stage. There was no association between IS and any of the clinicopathological variables. IS was shown to be an independent prognostic factor for better DSS and OS in multivariate analysis, together with the histological grade of the tumor and perineural invasion. Five MLH1-negative tumors (4.6%) were found showing no correlation with IS. IS could be a useful prognostic marker in patients with PDAC treated by primary surgery.
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            Microsatellite instability
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      headline:High immune cell score predicts improved survival in pancreatic cancer
      description:Increasing evidence suggests that cancer progression is strongly influenced by host immune response, which is represented by immune cell infiltrates. T-lymphocyte-based immunoscore has proved to be a prognostic factor in colon cancer, but its significance in pancreatic cancer is poorly known. Total of 108 patients operated (R0/R1) for pancreatic ductal adenocarcinoma (PDAC) (TNM stage I–II) were included in the study. Immune cell score (IS) was determined by scoring the samples from grade 0 to 4 according to the number of immune cells (CD3+ and CD8+) in tumor core and invasion margin using tissue microarrays, immunohistochemistry, and digital analysis. Tumors with microsatellite instability were identified by MLH1 immunostaining. High IS and low histological grade were significantly associated with better disease-specific survival (DSS) and overall survival (OS). The 5-year DSS rate for low, moderate, and high IS groups were 5.0, 15.2, and 33.4%, respectively (p = 0.007). The 5-year OS rate for the low, moderate, and high IS groups were 4.2, 13.4, and 31.5%, respectively (p = 0.004). In addition, IS and prognosis varied within a single TNM stage. There was no association between IS and any of the clinicopathological variables. IS was shown to be an independent prognostic factor for better DSS and OS in multivariate analysis, together with the histological grade of the tumor and perineural invasion. Five MLH1-negative tumors (4.6%) were found showing no correlation with IS. IS could be a useful prognostic marker in patients with PDAC treated by primary surgery.
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         Pathology
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