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Keywords {🔍}

tumors, pubmed, tumor, classification, cns, article, diffuse, google, scholar, molecular, idh, grade, astrocytoma, genetic, features, central, gliomas, brain, histological, glioblastoma, diagnosis, neuropathol, acta, cas, entities, diagnostic, anaplastic, defined, cancer, oligodendroglioma, university, idhmutant, grading, glioblastomas, cells, expression, nos, entity, diagnoses, clinical, table, research, solitary, fibrous, cases, idhwildtype, glioma, ependymoma, similar, mutation,

Topics {✒️}

nf-kappab signaling pathway post-contrast t1 mri kees kleihues-van tol recurrent nab2-stat6 fusion atypical teratoid/rhabdoid tumor perivascular virchow-robin spaces central nervous system neuro-oncological clinical advisors pediatric low-grade gliomas copy-number profiling identify h3 k27–mutant protein full size image atypical teratoid/rhabdoid tumors false-positive fish results lysosome-rich tumor cells diffuse lower-grade gliomas nerve sheath tumors large cell/anaplastic features rela fusion–positive ependymoma ep-gbms show features partner site essen/duesseldorf andreas von deimling false-negative atrx immunostaining 1p/19q-codeleted includes phenotype–genotype correlation grows mixed neuronal-glial tumours van thuijl hf increased cell size 1p/19q codeletion status idh-wildtype epithelioid glioblastomas anaplastic-level diffuse gliomas tert promoter mutations including idh-mutant astrocytic rodriguez fj combined phenotypic–genotypic diagnostics privacy choices/manage cookies hematopoietic/lymphoid pathology community eastern cancer registration cell–cell wrapping t2-weighted mri rela fusion–positive rela fusion–positive [33 adult malignant gliomas c19mc-amplified tumors include idh-mutant cases appears low-grade precursor erasmus medical center exome sequencing identifies shh/wnt molecular subgroups solitary fibrous tumor

Questions {❓}

• Alexandrescu S, Korshunov A, Lai SH, Dabiri S, Patil S, Li R, Shih CS, Bonnin JM, Baker JA, Du E et al (2015) Epithelioid glioblastomas and anaplastic epithelioid pleomorphic xanthoastrocytomas—same entity or first cousins?
• Huse JT, Diamond EL, Wang L, Rosenblum MK (2015) Mixed glioma with molecular features of composite oligodendroglioma and astrocytoma: a true “oligoastrocytoma”?
• Louis DN (2012) The next step in brain tumor classification: “Let us now praise famous men”… or molecules?
• Wilcox P, Li CC, Lee M, Shivalingam B, Brennan J, Suter CM, Kaufman K, Lum T, Buckland ME (2015) Oligoastrocytomas: throwing the baby out with the bathwater?

Schema {🗺️}

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         headline:The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
         description:The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor. For the first time, the WHO classification of CNS tumors uses molecular parameters in addition to histology to define many tumor entities, thus formulating a concept for how CNS tumor diagnoses should be structured in the molecular era. As such, the 2016 CNS WHO presents major restructuring of the diffuse gliomas, medulloblastomas and other embryonal tumors, and incorporates new entities that are defined by both histology and molecular features, including glioblastoma, IDH-wildtype and glioblastoma, IDH-mutant; diffuse midline glioma, H3 K27M–mutant; RELA fusion–positive ependymoma; medulloblastoma, WNT-activated and medulloblastoma, SHH-activated; and embryonal tumour with multilayered rosettes, C19MC-altered. The 2016 edition has added newly recognized neoplasms, and has deleted some entities, variants and patterns that no longer have diagnostic and/or biological relevance. Other notable changes include the addition of brain invasion as a criterion for atypical meningioma and the introduction of a soft tissue-type grading system for the now combined entity of solitary fibrous tumor / hemangiopericytoma—a departure from the manner by which other CNS tumors are graded. Overall, it is hoped that the 2016 CNS WHO will facilitate clinical, experimental and epidemiological studies that will lead to improvements in the lives of patients with brain tumors.
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      headline:The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
      description:The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor. For the first time, the WHO classification of CNS tumors uses molecular parameters in addition to histology to define many tumor entities, thus formulating a concept for how CNS tumor diagnoses should be structured in the molecular era. As such, the 2016 CNS WHO presents major restructuring of the diffuse gliomas, medulloblastomas and other embryonal tumors, and incorporates new entities that are defined by both histology and molecular features, including glioblastoma, IDH-wildtype and glioblastoma, IDH-mutant; diffuse midline glioma, H3 K27M–mutant; RELA fusion–positive ependymoma; medulloblastoma, WNT-activated and medulloblastoma, SHH-activated; and embryonal tumour with multilayered rosettes, C19MC-altered. The 2016 edition has added newly recognized neoplasms, and has deleted some entities, variants and patterns that no longer have diagnostic and/or biological relevance. Other notable changes include the addition of brain invasion as a criterion for atypical meningioma and the introduction of a soft tissue-type grading system for the now combined entity of solitary fibrous tumor / hemangiopericytoma—a departure from the manner by which other CNS tumors are graded. Overall, it is hoped that the 2016 CNS WHO will facilitate clinical, experimental and epidemiological studies that will lead to improvements in the lives of patients with brain tumors.
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         Astrocytoma
         Medulloblastoma
         Oligodendroglioma
         Pilocytic Astrocytoma
         Malignant Peripheral Nerve Sheath Tumor
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         Neurosciences
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      name:German Cancer Consortium (DKTK), Partner Site Essen/Duesseldorf, Germany
      name:German Cancer Consortium (DKTK), Partner Site Essen/Duesseldorf, Germany
      name:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany
      name:Department of Pathology and Neuropathology, La Timone Hospital, Aix Marseille University, Marseille, France
      name:Ludwig Institute for Cancer Research, University of California San Diego, San Diego, USA
      name:International Agency for Research on Cancer (IARC), Lyon, France
      name:German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Medical Faculty, University of Zurich, Zurich, Switzerland
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