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Title[redir]:
The American Journal of Surgical Pathology
Description:
ma multiforme (GC-GBMs). GC-GBMs and epithelioid GBMs (E-GBMs) can be histologically challenging to distinguish from PXA-A. We undertook this study specifically to address whether these 2 tumor types also showed the mutation. We tested our originally reported cohort of 8 E-GBMs and 2 rhabdoid GBMs (R-GBM) as well as 5 new E-GBMs (1 pediatric, 4 adult) and 9 GC-GBMs (2 pediatric, 7 adult) (n=24) for BRAF V600E mutational status. Twenty-one of 24 had sufficient material for IDH-1 immunostaining, which is usually absent in PXAs, PXA-As, and primary GBMs but present in secondary GBMs. Patients ranged in age from 4 to 67 years. BRAF V600E mutation was identified in 7/13 of E-GBMs, including 3 of our original cases; patients with mutation were aged 10 to 50 years. None of the 9 GC-GBMs or 2 R-GBMs manifested this mutation, including pediatric patients. The sole secondary E-GBM was the single case manifesting positive IDH-1 immunoreactivity. A high percentage of E-GBMs manifest BRAF V600E mutation, paralleling PXAs. All R-GBMs and GC-GBMs were negative, although larger multi-institutional cohorts will have to be tested to extend this result. BRAF V600E mutational analyses should be performed on E-GBMs, particularly in all pediatric and young-aged adults, given the potential for BRAF inhibitor therapy in this subset of GBM patients....
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Keywords {🔍}
journal, braf, mutation, egbms, gbms, gcgbms, issue, pxas, pediatric, patients, access, subscribe, alerts, secondary, articles, authors, abstract, epithelioid, health, log, register, logo, issues, original, high, percentage, pathology, buy, identified, pxaa, cell, study, tumor, tested, adult, mutational, idh, years, including, cases, rgbms, copyright, wolters, kluwer, rights, reserved, text, subscribers, request, article,
Topics {✒️}
read mucin-rich variant larger multi-institutional cohorts sole secondary e-gbm braf v600e mutation braf inhibitor therapy journal authors submit full text access salivary duct carcinoma extracerebellar pilocytic astrocytomas originally reported cohort artificial intelligence training cellular endocrine pathology bette kay md secondary gbms young-aged adults etoc alerts 2 r-gbms manifested service request 800-638-3030 register subscribe individual subscribers log epithelioid gbms american journal journal tables 2 tumor types idh-1 immunostaining issue original cases including pediatric patients e-gbms 8 e-gbms r-gbm website subscribe r-gbms gbm patients journal surgical pathology 37 gc-gbms 2 rhabdoid gbms 9 gc-gbms primary gbms center submit high percentage pleomorphic xanthoastrocytomas varying percentages anaplastic features histologically challenging study specifically sufficient material patients ranged rights reserved
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