We are analyzing https://link.springer.com/article/10.1007/s00253-014-5721-8.

Title:
Role of autophagy and its significance in cellular homeostasis | Applied Microbiology and Biotechnology
Description:
Autophagy is a catabolic pathway that regulates homeostasis in cells. It is an exceptional pathway of membrane trafficking. Autophagy is characterized by the formation of double-membrane vesicles; autophagosomes that are responsible for delivering damaged organelle and extra proteins to lysosome for recycling. A series of actions including environmental and genetic factors are responsible for induction of autophagy. In the past few decades, the research on autophagy has been immensely expanded because it is a vital process in maintaining cellular balance as well as deeply connected with pathogenesis of a number of diseases. The aim of this review is to present an overview of modern work on autophagy and highlight some essential genetic role in the induction of autophagy. There is an emerging need to identify, quantify, and manipulate the pathway of autophagy, due to its close relationship with a variety of developmental pathways and functions especially in cancer, diabetes, neurodegenerative disorders, and infectious diseases.
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Keywords {🔍}

pubmed, google, scholar, cas, autophagy, cell, central, biol, death, cells, cancer, autophagic, mol, chem, protein, article, res, apoptosis, human, role, ohsumi, klionsky, essential, pathway, formation, induction, mitochondrial, molecular, regulation, sci, control, stress, induces, zhang, homeostasis, proteins, beclin, degradation, rev, kinase, atg, levine, yang, privacy, cookies, content, yulin, regulates, diseases, functions,

Topics {✒️}

calmodulin-dependent kinase kinase-β month download article/chapter p62/sqstm1 binds directly beclinphosphatidylinositol3-kinase complex functions alpha-synuclein decreased viability lc3 recruit p62/sqstm1 huntingtin-induced cell death sin-1-induced cell death tobacco suspension-cultured cells human autophagy-related genes breast cancer—pilot study caspase-independent cell death chaperone-mediated autophagy article applied microbiology akt-tsc2-mtor signaling autophagy-unanswered questions mutant alpha-synuclein intracellular protein catabolism emerging anti-aging mechanism privacy choices/manage cookies p53-induced modulator malignant glioma cells liang xh human glioma cells amino acid levels chaperson-mediated autophagy autophagic cell death human lung cells macrophage autophagy induced radiation induced autophagy removing protein aggregates ubiquitinated protein aggregates differentiated neuroblastoma cells affects mitochondrial polarity short mitochondrial form salinomycin induces activation death domain protein full article pdf human glioblastoma cells caspase-independent manner programmed cell death related subjects selective autophagy mediated human map1lc3 family macroautophagy versus endocytosis pi3k/akt pathway proteinase-deficient mutants autophagic vesicles inside autophagic adapter proteins transmembrane protein interacting

Questions {❓}

Ischiropoulos H, Beckman JS (2003) Oxidative stress and nitration in neurodegeneration: cause, effect, or association?
Jing K, Lim K (2012) Why is autophagy important in human diseases?

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