We are analyzing https://link.springer.com/article/10.1007/s00018-021-03965-w.

Title:
The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events | Cellular and Molecular Life Sciences
Description:
The double-stranded multifunctional RNA-binding protein (dsRBP) Staufen was initially discovered in insects as a regulator of mRNA localization. Later, its mammalian orthologs have been described in different organisms, including humans. Two human orthologues of Staufen, named Staufen1 (STAU1) and Staufen2 (STAU2), share some structural and functional similarities. However, given their different spatio-temporal expression patterns, each of these orthologues plays distinct roles in cells. In the current review, we focus on the role of STAU1 in cell functions and cancer development. Since its discovery, STAU1 has mostly been studied for its involvement in various aspects of RNA metabolism. Given the pivotal role of RNA metabolism within cells, recent studies have explored the mechanistic impact of STAU1 in a wide variety of cell functions ranging from cell growth to cell death, as well as in various disease states. In particular, there has been increasing attention on the role of STAU1 in neuromuscular disorders, neurodegeneration, and cancer. Here, we provide an overview of the current knowledge on the role of STAU1 in RNA metabolism and cell functions. We also highlight the link between STAU1-mediated control of cellular functions and cancer development, progression, and treatment. Hence, our review emphasizes the potential of STAU1 as a novel biomarker and therapeutic target for cancer diagnosis and treatment, respectively.
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Keywords {🔍}

stau, cell, pubmed, article, cancer, google, scholar, cells, cas, mrna, staufen, central, role, differentiation, protein, mrnas, rna, expression, polarity, binding, cellular, development, impact, translation, autophagy, functions, stress, localization, growth, control, proteins, apoptosis, target, formation, regulation, rnabinding, migration, promotes, smd, roles, disease, shown, direct, biol, function, human, splicing, degradation, essential, response,

Topics {✒️}

double-stranded rna-binding protein double-stranded rna-binding domains cyclin-dependent kinase cdkn1a/p21 crawford parks te article download pdf stau1-mediated post-transcriptional regulation activating perk-chop pathway alu-pair stau1-binding sites ire1-xbp-1-ridd axis rab11-family-interacting protein 1 sh-sy5y cell line short stem-loop structures differentiated sh-sy5y cells fine-tuning ezh2 expression central dogma decentralized nonsense-mediated mrna decay rna-binding protein staufen1 mis-migrating pgcs failed short interspersed nuclear elements tdp-43/fmrp/stau1 proteins binds terminal differentiation-induced ncrna brain-specific microrna mir-124 staufen1-mediated mrna decay rna-binding protein hur c-myc-dependent mechanism human rna-binding proteins spatio-temporal expression patterns drosophila long-term memory promote muscle-related cancers degenerate dsrna-binding domain rna-binding protein znf423 double-stranded-rna activates caspase-dependent apoptosis neuro-2a cell lines apical–basal polarity markers cell–cell adhesion properties drives cell-cycle progression rna-binding protein staufen thapsigargin-induced cellular stress stau1-mediated alternative splicing neuroblast daughter-cell fate stau1-mediated mrna decay staufen-mediated mrna decay involves epithelial–mesenchymal transition crawford te increased stau1-mediated degradation protein-coding rnas cell cycle-dependent regulation dendritic staufen1-rnp delivery full size image

Questions {❓}

Jan YN, Jan LY (2000) Polarity in cell division: what frames thy fearful asymmetry?

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         headline:The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events
         description:The double-stranded multifunctional RNA-binding protein (dsRBP) Staufen was initially discovered in insects as a regulator of mRNA localization. Later, its mammalian orthologs have been described in different organisms, including humans. Two human orthologues of Staufen, named Staufen1 (STAU1) and Staufen2 (STAU2), share some structural and functional similarities. However, given their different spatio-temporal expression patterns, each of these orthologues plays distinct roles in cells. In the current review, we focus on the role of STAU1 in cell functions and cancer development. Since its discovery, STAU1 has mostly been studied for its involvement in various aspects of RNA metabolism. Given the pivotal role of RNA metabolism within cells, recent studies have explored the mechanistic impact of STAU1 in a wide variety of cell functions ranging from cell growth to cell death, as well as in various disease states. In particular, there has been increasing attention on the role of STAU1 in neuromuscular disorders, neurodegeneration, and cancer. Here, we provide an overview of the current knowledge on the role of STAU1 in RNA metabolism and cell functions. We also highlight the link between STAU1-mediated control of cellular functions and cancer development, progression, and treatment. Hence, our review emphasizes the potential of STAU1 as a novel biomarker and therapeutic target for cancer diagnosis and treatment, respectively.
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      headline:The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events
      description:The double-stranded multifunctional RNA-binding protein (dsRBP) Staufen was initially discovered in insects as a regulator of mRNA localization. Later, its mammalian orthologs have been described in different organisms, including humans. Two human orthologues of Staufen, named Staufen1 (STAU1) and Staufen2 (STAU2), share some structural and functional similarities. However, given their different spatio-temporal expression patterns, each of these orthologues plays distinct roles in cells. In the current review, we focus on the role of STAU1 in cell functions and cancer development. Since its discovery, STAU1 has mostly been studied for its involvement in various aspects of RNA metabolism. Given the pivotal role of RNA metabolism within cells, recent studies have explored the mechanistic impact of STAU1 in a wide variety of cell functions ranging from cell growth to cell death, as well as in various disease states. In particular, there has been increasing attention on the role of STAU1 in neuromuscular disorders, neurodegeneration, and cancer. Here, we provide an overview of the current knowledge on the role of STAU1 in RNA metabolism and cell functions. We also highlight the link between STAU1-mediated control of cellular functions and cancer development, progression, and treatment. Hence, our review emphasizes the potential of STAU1 as a novel biomarker and therapeutic target for cancer diagnosis and treatment, respectively.
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