We are analyzing https://link.springer.com/article/10.1007/s00018-017-2628-4.

Title:
Exploiting non-canonical translation to identify new targets for T cell-based cancer immunotherapy | Cellular and Molecular Life Sciences
Description:
Cryptic MHC I-associated peptides (MAPs) are produced via two mechanisms: translation of protein-coding genes in non-canonical reading frames and translation of allegedly non-coding sequences. In general, cryptic MAPs are coded by relatively short open reading frames whose translation can be regulated at the level of initiation, elongation or termination. In contrast to conventional MAPs, the processing of cryptic MAPs is frequently proteasome independent. The existence of cryptic MAPs derived from allegedly non-coding regions enlarges the scope of CD8 T cell immunosurveillance from a mere ~2% to as much as ~75% of the human genome. Considering that 99% of cancer-specific mutations are located in those allegedly non-coding regions, cryptic MAPs could furthermore represent a particularly rich source of tumor-specific antigens. However, extensive proteogenomic analyses will be required to determine the breath as well as the temporal and spatial plasticity of the cryptic MAP repertoire in normal and neoplastic cells.
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Keywords {🔍}

pubmed, article, google, scholar, cas, central, cell, translation, human, class, mhc, van, nat, reading, peptides, cancer, antigen, immunol, nature, biol, med, cells, exp, open, res, mol, cryptic, initiation, rev, gene, perreault, frames, ribosomal, protein, sci, acids, peptide, nucleic, lymphocytes, alternative, codon, complex, usa, response, atkins, readthrough, frameshifting, molecules, proc, natl,

Topics {✒️}

selective graft-versus-leukemia depends month download article/chapter aug-initiated n-terminal extensions paired-end rna-seq data melanoma-reactive tumor-infiltrating lymphocytes microsatellite-instable haematological malignancies van der horst-bruinsma class i-restricted cytotoxic target-specific immune responses ribosome-profiling data reveals melanoma-shared tumor antigen van luxemburg-heijs sa ovalbumin peptide/kb complex pre-spliced rnas cd8+ t-cell responses tapasin-negative cell line treating msi + blood cancers frame peptide/mhc class natural suppressor trnas annotated protein-coding genes full article pdf major histocompatibility complex allele-specific motifs revealed frame aug codon prevalent translational repressors open reading frames stop codon read alternative reading frames aug initiator codon cell-based cancer immunotherapy translational readthrough cap-dependent scanning mechanism programmed ribosomal frameshifting mass-spectrometry-based draft stop codon suppression canonical reading frames article laumont primary initiation codon tyrosinase-related protein van der stok canadian research chair termination complex formation privacy choices/manage cookies tumor-infiltrating cd8 ctl epitopes encoded related subjects ribosome profiling data ivanov ip gerashchenko mv mammalian cells reveals

Questions {❓}

Van Deutekom HW, Kesmir C (2015) Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most?

Schema {🗺️}

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         headline:Exploiting non-canonical translation to identify new targets for T cell-based cancer immunotherapy
         description:Cryptic MHC I-associated peptides (MAPs) are produced via two mechanisms: translation of protein-coding genes in non-canonical reading frames and translation of allegedly non-coding sequences. In general, cryptic MAPs are coded by relatively short open reading frames whose translation can be regulated at the level of initiation, elongation or termination. In contrast to conventional MAPs, the processing of cryptic MAPs is frequently proteasome independent. The existence of cryptic MAPs derived from allegedly non-coding regions enlarges the scope of CD8 T cell immunosurveillance from a mere ~2% to as much as ~75% of the human genome. Considering that 99% of cancer-specific mutations are located in those allegedly non-coding regions, cryptic MAPs could furthermore represent a particularly rich source of tumor-specific antigens. However, extensive proteogenomic analyses will be required to determine the breath as well as the temporal and spatial plasticity of the cryptic MAP repertoire in normal and neoplastic cells.
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            Biochemistry
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      description:Cryptic MHC I-associated peptides (MAPs) are produced via two mechanisms: translation of protein-coding genes in non-canonical reading frames and translation of allegedly non-coding sequences. In general, cryptic MAPs are coded by relatively short open reading frames whose translation can be regulated at the level of initiation, elongation or termination. In contrast to conventional MAPs, the processing of cryptic MAPs is frequently proteasome independent. The existence of cryptic MAPs derived from allegedly non-coding regions enlarges the scope of CD8 T cell immunosurveillance from a mere ~2% to as much as ~75% of the human genome. Considering that 99% of cancer-specific mutations are located in those allegedly non-coding regions, cryptic MAPs could furthermore represent a particularly rich source of tumor-specific antigens. However, extensive proteogenomic analyses will be required to determine the breath as well as the temporal and spatial plasticity of the cryptic MAP repertoire in normal and neoplastic cells.
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         Major histocompatibility complex class I
         Cytotoxic T cells
         Antigen processing
         Antigen presentation
         Protein synthesis
         Neoantigens
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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