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month download article/chapter low-carbohydrate high-protein diet low-carbohydrate-high-protein diet low-protein high-carbohydrate diets low-fat/low-calorie diets rafael de cabo samantha solon-biet & victoria alistair senior ad libitum-fed animals author information authors full article pdf carbohydrate-restricted diets samantha solon-biet diminishes age-related disease gonzalez-reyes ja geometric framework studies le couteur dg ad libitum-fed mice dietary protein life-span lopez-lluch high-carbohydrate diets genetically heterogeneous mice short term calorie author correspondence low-carbohydrate diets krzysik-walker sm paoli pp privacy choices/manage cookies related subjects high-calorie diet low tryptophan diet high-protein diet longevity-fertility trade-offs geometric framework sex-specific fitness effects van der ad long-term survival high-protein score health span based related risk factors solon sm amino acid supplements diet-induced obesity chemically defined diet adult worker bumblebee amino acid restriction 0539 solon-biet solon-biet mitochondrial oxidative stress general population cohort

Questions {❓}

• Adler MI, Bonduriansky R (2014) Why do the well-fed appear to die young?
• Baur JA, Ungvari Z, Minor RK, Le Couteur DG, de Cabo R (2012) Are sirtuins proper targets for improving healthspan and lifespan?
• Landsberg L (2012) Core temperature: a forgotten variable in energy expenditure and obesity?
• Rizza W, Veronese N, Fontana L (2014) What are the roles of calorie restriction and diet quality in promoting healthy longevity?
• Simpson SJ, Batley R, Raubenheimer D (2003) Geometric analysis of macronutrient intake in humans: the power of protein?

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      description:Most research on nutritional effects on aging has focussed on the impact of manipulating single dietary factors such as total calorie intake or each of the macronutrients individually. More recent studies using a nutritional geometric approach called the Geometric Framework have facilitated an understanding of how aging is influenced across a landscape of diets that vary orthogonally in macronutrient and total energy content. Such studies have been performed using ad libitum feeding regimes, thus taking into account compensatory feeding responses that are inevitable in a non-constrained environment. Geometric Framework studies on insects and mice have revealed that diets low in protein and high in carbohydrates generate longest lifespans in ad libitum-fed animals while low total energy intake (caloric restriction by dietary dilution) has minimal effect. These conclusions are supported indirectly by observational studies in humans and a heterogeneous group of other types of interventional studies in insects and rodents. Due to compensatory feeding for protein dilution, low-protein, high-carbohydrate diets are often associated with increased food intake and body fat, a phenomenon called protein leverage. This could potentially be mitigated by supplementing these diets with interventions that influence body weight through physical activity and ambient temperature.
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