We are analyzing https://link.springer.com/article/10.1007/s00018-013-1423-0.

Title:
Cell cycle regulation by long non-coding RNAs | Cellular and Molecular Life Sciences
Description:
The mammalian cell cycle is precisely controlled by cyclin-dependent kinases (CDKs) and related pathways such as the RB and p53 pathways. Recent research on long non-coding RNAs (lncRNAs) indicates that many lncRNAs are involved in the regulation of critical cell cycle regulators such as the cyclins, CDKs, CDK inhibitors, pRB, and p53. These lncRNAs act as epigenetic regulators, transcription factor regulators, post-transcription regulators, and protein scaffolds. These cell cycle-regulated lncRNAs mainly control cellular levels of cell cycle regulators via various mechanisms, and may provide diversity and reliability to the general cell cycle. Interestingly, several lncRNAs are induced by DNA damage and participate in cell cycle arrest or induction of apoptosis as DNA damage responses. Therefore, deregulations of these cell cycle regulatory lncRNAs may be involved in tumorigenesis, and they are novel candidate molecular targets for cancer therapy and diagnosis.
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Keywords {🔍}

cell, article, google, scholar, cycle, pubmed, cas, expression, gene, transcription, lncrnas, regulation, cdk, dna, rna, noncoding, genes, regulators, anril, cancer, damage, ink, target, locus, induced, cyclin, involved, long, lncrna, prc, control, complex, binds, prb, fig, pathway, human, table, ccnd, rnas, response, family, tumor, biol, inhibitors, regulates, mrna, cellular, kitagawa, protein,

Topics {✒️}

cbp/p300–pcaf–creb coactivator complex article download pdf rck/p54 rna helicase target cyclin–cdk complexes dna double-strand breaks hbv-related hepatocellular carcinoma cip/kip family inhibitors men2a-ret-mediated mitogenesis p21 promoter-derived transcript dna damage-inducible transcript p53-regulated tumor suppressor post-translational modification network beckwith–wiedemann syndrome promote protein–protein interactions p53-dependent enhancer activity wild-type p53 binds dna damage-dependent manner targets including apc/cyclosome cell cycle-promoting genes cyclin d1 proto-oncogene tumor suppressor prb atm-e2f1 signaling pathway cyclin d1–cdk6 complex ncrna dna damage-activated full access tumor suppressor gene entire ink4/arf locus suppressing doxorubicin-induced g2/ tumor suppressor p53 privacy choices/manage cookies cell cycle-regulated lncrnas activate e2f-mediated transcription lncrna-p21 directly interact long noncoding rna site-specific dna methylation tumor suppressor function pre-adipocytes downregulates menin-ret-signaling h19 lncrna/mir-675 expression long noncoding rnas human hepatocellular carcinoma inactivate cdk activity cell cycle arrest prb family proteins cell-cycle inhibitors ubiquitin-dependent degradation antisense noncoding rna important tumor suppressor cyclin-dependent kinases cyclin dependent kinases

Schema {🗺️}

WebPage:
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         headline:Cell cycle regulation by long non-coding RNAs
         description:The mammalian cell cycle is precisely controlled by cyclin-dependent kinases (CDKs) and related pathways such as the RB and p53 pathways. Recent research on long non-coding RNAs (lncRNAs) indicates that many lncRNAs are involved in the regulation of critical cell cycle regulators such as the cyclins, CDKs, CDK inhibitors, pRB, and p53. These lncRNAs act as epigenetic regulators, transcription factor regulators, post-transcription regulators, and protein scaffolds. These cell cycle-regulated lncRNAs mainly control cellular levels of cell cycle regulators via various mechanisms, and may provide diversity and reliability to the general cell cycle. Interestingly, several lncRNAs are induced by DNA damage and participate in cell cycle arrest or induction of apoptosis as DNA damage responses. Therefore, deregulations of these cell cycle regulatory lncRNAs may be involved in tumorigenesis, and they are novel candidate molecular targets for cancer therapy and diagnosis.
         datePublished:2013-07-24T00:00:00Z
         dateModified:2013-07-24T00:00:00Z
         pageStart:4785
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            Life Sciences
            Biochemistry
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      headline:Cell cycle regulation by long non-coding RNAs
      description:The mammalian cell cycle is precisely controlled by cyclin-dependent kinases (CDKs) and related pathways such as the RB and p53 pathways. Recent research on long non-coding RNAs (lncRNAs) indicates that many lncRNAs are involved in the regulation of critical cell cycle regulators such as the cyclins, CDKs, CDK inhibitors, pRB, and p53. These lncRNAs act as epigenetic regulators, transcription factor regulators, post-transcription regulators, and protein scaffolds. These cell cycle-regulated lncRNAs mainly control cellular levels of cell cycle regulators via various mechanisms, and may provide diversity and reliability to the general cell cycle. Interestingly, several lncRNAs are induced by DNA damage and participate in cell cycle arrest or induction of apoptosis as DNA damage responses. Therefore, deregulations of these cell cycle regulatory lncRNAs may be involved in tumorigenesis, and they are novel candidate molecular targets for cancer therapy and diagnosis.
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         DNA damage response
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         CDK inhibitor
         pRB
         p53
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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            address:
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            address:
               name:Department of Biological and Environmental Chemistry, Faculty of Humanity-Oriented Science and Engineering, Kinki University, Fukuoka, Japan
               type:PostalAddress
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      affiliation:
            name:Hamamatsu University School of Medicine
            address:
               name:Department of Molecular Biology, Hamamatsu University School of Medicine, Hamamatsu, Japan
               type:PostalAddress
            type:Organization
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      affiliation:
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            address:
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      name:Department of Biological and Environmental Chemistry, Faculty of Humanity-Oriented Science and Engineering, Kinki University, Fukuoka, Japan
      name:Department of Molecular Biology, Hamamatsu University School of Medicine, Hamamatsu, Japan
      name:Department of Molecular Biology, Hamamatsu University School of Medicine, Hamamatsu, Japan

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