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Title[redir]:
Hepatology
Description:
HCC and paired peritumoral tissues were identified by microarray and validated using quantitative real-time polymerase chain reaction. Liver samples from patients with HBV-related HCC were analyzed for levels of a specific differentially expressed lncRNA High Expression In HCC (termed lncRNA-HEIH); data were compared with survival data using the Kaplan-Meier method and compared between groups by the log-rank test. The effects of lncRNA-HEIH were assessed by silencing and overexpressing the lncRNA in vitro and in vivo. The expression level of lncRNA-HEIH in HBV-related HCC is significantly associated with recurrence and is an independent prognostic factor for survival. We also found that lncRNA-HEIH plays a key role in G0/G1 arrest, and further demonstrated that lncRNA-HEIH was associated with enhancer of zeste homolog 2 (EZH2) and that this association was required for the repression of EZH2 target genes. Conclusions: Together, these results indicate that lncRNA-HEIH is an oncogenic lncRNA that promotes tumor progression and leads us to propose that lncRNAs may serve as key regulatory hubs in HCC progression. (Hepatology 2011...
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Keywords {π}
hcc, lncrnaheih, aasld, liver, hepatology, log, journal, lncrnas, hbvrelated, access, subscribe, issue, alerts, abstract, expression, lncrna, data, association, register, member, logo, browse, submit, long, noncoding, high, hepatocellular, carcinoma, tumor, enhancer, zeste, homolog, yang, zhang, yuan, wang, buy, regulatory, differentially, expressed, compared, survival, key, ezh, progression, copyright, american, study, diseases, text,
Topics {βοΈ}
long noncoding rnas aasld members log open access policy related hepatocellular carcinoma log-rank test differentially expressed lncrnas individual subscribers log liver diseases promotes tumor progression institutional users access critical regulatory roles remain largely unknown paired peritumoral tissues kaplan-meier method independent prognostic factor g0/g1 arrest artificial intelligence training key regulatory hubs full text access liver samples ezh2 target genes termed lncrna-heih lncrna-heih plays hbv-related hcc 24563 buy abstract expression level journal tables register subscribe service request 800-638-3030 lncrna-heih journal hcc progression website subscribe oncogenic lncrna key role zeste homolog 2 xi-song1 ji-hang1 sheng-xian2 wei-ping2 guang-shun3 yu-zhao1 jing-li1 chun-fang4 feng-rui5 shu-han1 recent years cancer biology email inbox rights reserved
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