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Title:
Hematopoietic Stem Cell Heterogeneity | SpringerLink
Description:
Hematopoietic stem cells (HSCs) maintain lifelong production of mature blood cells and regenerate the hematopoietic system after cytotoxic injury. Use of expanding cell surface marker panels and advanced functional analyses have revealed the presence of several...
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Keywords {🔍}

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Schema {🗺️}

ScholarlyArticle:
      headline:Hematopoietic Stem Cell Heterogeneity
      pageEnd:211
      pageStart:195
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-030-24108-7.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Stem Cells Heterogeneity in Different Organs
         isbn:
            978-3-030-24108-7
            978-3-030-24107-0
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Roland Jurecic
            affiliation:
                  name:Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
                  address:
                     name:Department of Microbiology & Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Hematopoietic stem cellsHematopoiesisHSC subsetsFunctional heterogeneityDifferentiation bias
      description:Hematopoietic stem cells (HSCs) maintain lifelong production of mature blood cells and regenerate the hematopoietic system after cytotoxic injury. Use of expanding cell surface marker panels and advanced functional analyses have revealed the presence of several immunophenotypically different HSC subsets with distinct self-renewal and repopulating capacity and bias toward selective lineage differentiation. This chapter summarizes current understanding of the phenotypic and functional heterogeneity within the HSC pool, with emphasis on the immunophenotypes and functional features of several known HSC subsets, and their roles in steady-state and emergency hematopoiesis, and in aging. The chapter also highlights some of the future research directions to elucidate further the biology and function of different HSC subsets in health and disease states.
      datePublished:2019
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Book:
      name:Stem Cells Heterogeneity in Different Organs
      isbn:
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         978-3-030-24107-0
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      name:Springer International Publishing
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         type:ImageObject
      name:Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
      address:
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      affiliation:
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