We are analyzing https://link.springer.com/chapter/10.1007/5584_2019_464.

Title:
Adipose-Derived Mesenchymal Stem Cells Promote Growth and Migration of Lung Adenocarcinoma Cancer Cells | SpringerLink
Description:
Introduction: Mesenchymal stem cells (MSCs) have been used in cancer therapy as vehicles to deliver therapeutic materials such as drugs, apoptosis inducers and cytokines due to their ability to migrate and home at the tumour site. Furthermore, MSCs have been...
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Keywords {🔍}

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Topics {✒️}

adipose-derived stems cells human adipose-derived mscs autophagy-induced epithelial-mesenchymal transition neonatal tissue-derived msc er-sdf-1/cxcr4 crosstalk mesenchymal stem cells month download article/chapter badrul hisham yahaya bone marrow ad-mscs significantly enhanced stem cells international adipose-derived mouse mammary adenocarcinoma human cancer development tumor mouse models cancer treatment reviews a549 cancer cells privacy choices/manage cookies c6 glioma cells stem cells device instant download universiti sains malaysia paper zakaria cell surface proteins mesenchymal transition vietnam national university adenocarcinoma ad-mscs long-term aspect editor information editors ho chi minh conditions privacy policy research university grant tumor microenvironment european economic area deliver therapeutic materials promoting tumour growth fat tissue author information authors cancer cells ad-mscs promoted produce anticancer molecules a549 cells accepting optional cookies exosomes derived donor-matched comparison wnt signaling pathway metastatic characteristics main content log paper cite genetically engineered

Schema {🗺️}

ScholarlyArticle:
      headline:Adipose-Derived Mesenchymal Stem Cells Promote Growth and Migration of Lung Adenocarcinoma Cancer Cells
      pageEnd:95
      pageStart:83
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-030-57254-9.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Cancer Biology and Advances in Treatment
         isbn:
            978-3-030-57254-9
            978-3-030-57253-2
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Norashikin Zakaria
            affiliation:
                  name:Universiti Sains Malaysia
                  address:
                     name:Regenerative Medicine Cluster, Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas, Malaysia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Badrul Hisham Yahaya
            affiliation:
                  name:Universiti Sains Malaysia
                  address:
                     name:Regenerative Medicine Cluster, Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas, Malaysia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Adipose-derived stem cells, Co-culture, Lung cancer, MSCs
      description:Introduction: Mesenchymal stem cells (MSCs) have been used in cancer therapy as vehicles to deliver therapeutic materials such as drugs, apoptosis inducers and cytokines due to their ability to migrate and home at the tumour site. Furthermore, MSCs have been genetically engineered to produce anticancer molecules such as TRAIL that can induce apoptosis of cancer cells. However, MSCs’ presence in the tumour microenvironment has shown to be involved in promoting tumour growth and progression. Therefore, the roles of MSCs either promoting or suppressing tumorigenesis need to be investigated. Methods: Human adipose-derived MSCs (Ad-MSCs) and A549 cells are co-cultured together in indirect co-culture system using Transwell insert. Following co-culture, both cells were analysed in terms of growth rate, migration ability, apoptosis and gene expression for genes involved in migration and stemness characteristics. Results: The result shows that Ad-MSCs promoted the growth of A549 cells when indirectly co-cultured for 48 and 72 h. Furthermore, Ad-MSCs significantly enhanced the migration rate of A549 cells. The increased in migration rate was in parallel with the significant increase of MMP9. There are no significant changes observed in the expression of TWIST2, CDH2 and CDH1, genes involved in the epithelial-to-mesenchymal transition (EMT). Ad-MSCs also protect A549 cancer cells from undergoing apoptosis and increase the survival of cancer cells. Conclusion: Secretion of soluble factors from Ad-MSCs has been shown to promote the growth and metastatic characteristics of A549 cancer cells. Therefore, the use of Ad-MSCs in cancer therapy needs to be carefully evaluated in the long-term aspect.
      datePublished:2020
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Book:
      name:Cancer Biology and Advances in Treatment
      isbn:
         978-3-030-57254-9
         978-3-030-57253-2
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Universiti Sains Malaysia
      address:
         name:Regenerative Medicine Cluster, Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas, Malaysia
         type:PostalAddress
      name:Universiti Sains Malaysia
      address:
         name:Regenerative Medicine Cluster, Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas, Malaysia
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Norashikin Zakaria
      affiliation:
            name:Universiti Sains Malaysia
            address:
               name:Regenerative Medicine Cluster, Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas, Malaysia
               type:PostalAddress
            type:Organization
      name:Badrul Hisham Yahaya
      affiliation:
            name:Universiti Sains Malaysia
            address:
               name:Regenerative Medicine Cluster, Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas, Malaysia
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Regenerative Medicine Cluster, Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas, Malaysia
      name:Regenerative Medicine Cluster, Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas, Malaysia
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