
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks - PMC
Description:
We have utilized in vitro and mouse xenograft models to examine the interaction between breast cancer stem cells (CSCs) and bone marrow derived mesenchymal stem cells (MSCs). We demonstrate that both of these cell populations are organized in a ...
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Keywords {๐}
cells, cancer, mcs, stem, cell, breast, doi, sum, figure, tumor, cxcl, mscs, aldefluorpositive, mesenchymal, pubmed, google, scholar, human, cytokine, coculture, growth, cscs, aldh, population, expression, primary, bone, pmc, tumors, group, antibody, article, marrow, aldefluornegative, significant, aldhpositive, mice, shown, interaction, free, increased, lines, addition, results, compared, previously, assay, dsred, effect, utilized,
Topics {โ๏ธ}
real-time quantitative rt-pcr real-time rt-pcr showed aldh1+cd105โcd31โpan-ck+ aldh1+cd105+cd31โpan-ckโ real time rt-pcr intra-bone marrow injection bone marrow-derived mscs real-time qrt-pcr cancer stem-cell hypothesis direct cell/cell contact require cell-cell contact pan-cytokeratin ae1/ae3 21 csc/msc direct-contacts 14 csc/msc direct-contacts pmc beta search cy5-conjugated secondary antibody aldh1-positive mesenchymal cells cxcl7-transfected breast cells aldh1-positive cancer cells aldh1-positive tumor cells aldefluor-negative mesenchymal cells aldefluor-positive tumor cells similar msc-csc niches female nod/scid mice aldh1-positive sum159 cells isolate aldh-expressing subpopulations aldefluor-positive mc population pe-conjugated secondary antibody fitc-conjugated secondary antibody aldefluor-positive sum159 cells advanced breast cancers undergo multi-lineage differentiation multi-lineage differentiation interact invasion chambers pre-coated secondary nod/scid mice stem/progenitor marker aldefluor-positive population consistent anti-cxcl7 suggesting serum-free medium aldefluor-negative sum159 cells hematopoietic stem cell cancer stem cell identified โmsc-csc nichesโ established cell lines mammary stem cells cell stem cell inhibit tumor growth including breast cancer mesenchymal stem cells stromal stem cells
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