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Title:
Metabolic Changes During Cancer Cachexia Pathogenesis | SpringerLink
Description:
Wasting of adipose tissue and skeletal muscle is a hallmark of metastatic cancer and a major cause of death. Like patients with cachexia caused by other chronic infections or inflammatory diseases, the cancer subject manifests both malnutrition and metabolic stress....
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Keywords {🔍}

pubmed, google, scholar, cas, article, cancer, muscle, cachexia, central, skeletal, cell, patients, protein, physiol, res, factor, autophagy, clin, biol, med, human, sandri, myostatin, tisdale, biochem, expression, fearon, metab, loss, mice, metabolism, atrophy, lung, metabolic, cells, sci, wasting, tumor, lopezsoriano, natl, research, chapter, nature, argiles, science, glass, doijcmet, pathway, oncol, weight,

Topics {✒️}

/biotech/novartis-breakthrough-muscle-drug-bimagrumab-flunks-a-late-stage-trial sun yat-sen university late-stage trial nf-kappab mediates denervation-induced mitochondrial dysfunction branched-chain amino acids tumour necrosis factor-alpha tnf-alpha regulates myogenesis protein kinase b-dependent low-dose t3 administration rna-dependent protein kinase murine proteolysis-inducing factor doxorubicin-induced oxidative stress humanized anti-il-6 antibody pro-inflammatory cytokine release parathyroid hormone-related protein e3 ligase murf1 ubiquitin-dependent proteolytic system fiber-type specific dexamethasone-treated skeletal muscle steroidal anti-inflammatory treatment amino acid-dependent regulation plasma myostatin-immunoreactive protein ubiquitin-proteasome proteolytic pathway small-cell lung cancer lung cancer-induced cachexia cancer anorexia-cachexia syndrome hormone-sensitive lipase tumor-bearing nude mice pro-cachexia circulating factors brown adipose tissue fiber type specification proteolysis inducing factor proteolysis-inducing factor clarke ba atrophy-related genes double-blind trial complex multifactorial nature murf1-dependent ubiquitylation ng shyh-chang degrades cardiac troponin weight-losing cancer patients weight-losing cancer patients king penguin syndrome privacy choices/manage cookies excessive caloric expenditure chapter translational research maintain muscle mass human skeletal muscle differentially expressed message

Questions {❓}

Waning DL, Guise TA (2015) Cancer-associated muscle weakness: What's bone got to do with it?
Wieland BM, Stewart GD, Skipworth RJ, Sangster K, Fearon KC, Ross JA, Reiman TJ, Easaw J, Mourtzakis M, Kumar V, Pak BJ, Calder K, Filippatos G, Kremastinos DT, Palcic M, Baracos VE (2007) Is there a human homologue to the murine proteolysis-inducing factor?
Is there a human homologue to the murine proteolysis-inducing factor?

Schema {🗺️}

ScholarlyArticle:
      headline:Metabolic Changes During Cancer Cachexia Pathogenesis
      pageEnd:249
      pageStart:233
      image:https://media.springernature.com/w153/springer-static/cover/book/978-981-10-6020-5.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Translational Research in Breast Cancer
         isbn:
            978-981-10-6020-5
            978-981-10-6019-9
         type:Book
      publisher:
         name:Springer Singapore
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Ng Shyh-Chang
            affiliation:
                  name:Agency for Science Technology and Research
                  address:
                     name:Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Cachexia, Cancer, Metabolism, Circulating factors
      description:Wasting of adipose tissue and skeletal muscle is a hallmark of metastatic cancer and a major cause of death. Like patients with cachexia caused by other chronic infections or inflammatory diseases, the cancer subject manifests both malnutrition and metabolic stress. Both carbohydrate utilization and amino acid incorporation are decreased in the muscles of cancer cachexia patients. Cancer cells affect host metabolism in two ways: (a) their own metabolism of nutrients into other metabolites and (b) circulating factors they secrete or induce the host to secrete. Accelerated glycolysis and lactate production, i.e., the Warburg effect and the resultant increase in Cori cycle activity, are the most widely discussed metabolic effects. Meanwhile, although a large number of pro-cachexia circulating factors have been found, such as TNFa, IL-6, myostatin, and PTHrp, none have been shown to be a dominant factor that can be targeted singly to treat cancer cachexia in humans. It is possible that given the complex multifactorial nature of the cachexia secretome, and the personalized differences between cancer patients, targeting any single circulating factor would always be insufficient to treat cachexia for all patients. Here we review the metabolic changes that occur in response to tumor growth and tumor-secreted factors during cachexia.
      datePublished:2017
      isAccessibleForFree:
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Book:
      name:Translational Research in Breast Cancer
      isbn:
         978-981-10-6020-5
         978-981-10-6019-9
Organization:
      name:Springer Singapore
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Agency for Science Technology and Research
      address:
         name:Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Ng Shyh-Chang
      affiliation:
            name:Agency for Science Technology and Research
            address:
               name:Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

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