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Title:
Metabolic Features of Cancer Treatment Resistance | SpringerLink
Description:
A major barrier to achieving durable remission and a definitive cure in oncology patients is the emergence of tumor resistance, a common outcome of different disease types, and independent from the therapeutic approach undertaken. In recent years, subpopulations of...
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Questions {❓}

Garraway LA, Chabner B (2002) MDR1 inhibition: less resistance or less relevance?
Jang S, Atkins MB (2013) Which drug, and when, for patients with BRAF-mutant melanoma?
Jose C, Bellance N, Rossignol R (2011) Choosing between glycolysis and oxidative phosphorylation: a tumor’s dilemma?
Wolf DA (2014) Is reliance on mitochondrial respiration a “chink in the armor” of therapy-resistant cancer?
Gov What is cancer?

Schema {🗺️}

ScholarlyArticle:
      headline:Metabolic Features of Cancer Treatment Resistance
      pageEnd:156
      pageStart:135
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-42118-6.jpg
      genre:
         Medicine
         Medicine (R0)
      isPartOf:
         name:Metabolism in Cancer
         isbn:
            978-3-319-42118-6
            978-3-319-42116-2
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Andrea Viale
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Giulio F. Draetta
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Tumor resistance, Relapse, Cancer stem cell, Quiescence, Metabolism, Mitochondria, Oxidative phosphorylation
      description:A major barrier to achieving durable remission and a definitive cure in oncology patients is the emergence of tumor resistance, a common outcome of different disease types, and independent from the therapeutic approach undertaken. In recent years, subpopulations of slow-cycling cells endowed with enhanced tumorigenic potential and multidrug resistance have been isolated in different tumors, and mounting experimental evidence suggests these resistant cells are responsible for tumor relapse. An in-depth metabolic characterization of resistant tumor stem cells revealed that they rely more on mitochondrial respiration and less on glycolysis than other tumor cells, a finding that challenges the assumption that tumors have a primarily glycolytic metabolism and defective mitochondria. The demonstration of a metabolic program in resistant tumorigenic cells that may be present in the majority of tumors has important therapeutic implications and is a critical consideration as we address the challenge of identifying new vulnerabilities that might be exploited therapeutically.
      datePublished:2016
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Book:
      name:Metabolism in Cancer
      isbn:
         978-3-319-42118-6
         978-3-319-42116-2
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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      name:Andrea Viale
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Giulio F. Draetta
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
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