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Title:
Vitamin D Receptor Polymorphisms and Cancer | SpringerLink
Description:
Increasing scientific evidence supports the link between vitamin D and cancer risk. The active metabolite 1,25(OH)2D exerts its activity by binding to the vitamin D receptor (VDR), an intracellular receptor that mediates transcriptional activation and repression of...
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Keywords {🔍}

cancer, google, scholar, pubmed, vitamin, receptor, cas, gene, risk, polymorphisms, breast, association, polymorphism, prostate, vdr, central, res, med, int, colorectal, population, biol, wang, fok, metaanalysis, prev, chen, study, carcinoma, bsm, cell, zhang, epidemiol, susceptibility, biomarkers, variants, melanoma, liu, genes, casecontrol, genetic, soc, huang, oncol, clin, taq, studies, apa, role, mol,

Topics {✒️}

population-based case-control study cell cycle-regulatory proteins uk case-control comparisons month download article/chapter bueno-de-mesquita hb trans-acting factor alleles nested case-control study pakistani case-control study early-onset breast cancer pathway including genome-wide early-onset prostate cancer acad oral pathol vitamin d-related genes estrogen-metabolizing gene polymorphisms pre-treatment vd levels central south univ updated meta-analysis based privacy choices/manage cookies harriet ann johansson paffenbarger rs jr case-control study population-based study bmc med genet abd-alsalam hs med paediat oncol comp clin pathol pathol oncol res basal cell carcinomas oral cancer risk ethnic kashmiri population renal cell carcinoma basal cell carcinoma start codon polymorphisms soc clin oncol updated systematic meta-analysis fok1 variant supports device instant download related genetic variants 39 case-control studies case-control studies tobacco-related cancers hashem abo em cancer biol med single nucleotide polymorphism start codon fok1 exp biol med arch med sci cell adhes commun cell biochem funct exp mol med

Questions {❓}

Can vitamin D deficiency cause diabetes and cardiovascular diseases?
Do genetic polymorphisms of the vitamin D receptor contribute to breast/ovarian cancer?
Vitamin D and systemic cancer: is this relevant to malignant melanoma?
Vitamin D receptor polymorphisms or serum levels as key drivers of breast cancer development?

Schema {🗺️}

ScholarlyArticle:
      headline:Vitamin D Receptor Polymorphisms and Cancer
      pageEnd:114
      pageStart:53
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-030-46227-7.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Sunlight, Vitamin D and Skin Cancer
         isbn:
            978-3-030-46227-7
            978-3-030-46226-0
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Patrizia Gnagnarella
            affiliation:
                  name:IEO European Institute of Oncology IRCSS
                  address:
                     name:Division of Epidemiology and Biostatistics, IEO European Institute of Oncology IRCSS, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sara Raimondi
            affiliation:
                  name:IEO European Institute of Oncology IRCSS
                  address:
                     name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Valentina Aristarco
            affiliation:
                  name:IEO European Institute of Oncology IRCSS
                  address:
                     name:Division of Cancer Prevention and Genetics, IEO European Institute of Oncology IRCSS, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Harriet Ann Johansson
            affiliation:
                  name:IEO European Institute of Oncology IRCSS
                  address:
                     name:Division of Cancer Prevention and Genetics, IEO European Institute of Oncology IRCSS, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Federica Bellerba
            affiliation:
                  name:IEO European Institute of Oncology IRCSS
                  address:
                     name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Federica Corso
            affiliation:
                  name:IEO European Institute of Oncology IRCSS
                  address:
                     name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sara Gandini
            affiliation:
                  name:IEO European Institute of Oncology IRCSS
                  address:
                     name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:VDR polymorphisms, Vitamin D, Cancer, Fok1 , Bsm1 , Taq1 , Apa1 , Cdx2 , Breast cancer, Prostate cancer, Colon-rectum cancer, Melanoma, 25-Hydroxyvitamin D, Basal cell carcinoma, Squamous cell carcinoma, Renal cell carcinoma, Thyroid carcinoma, Esophageal adenocarcinoma, Hepatocellular carcinoma, Head and neck cancer, Non-Hodgkin lymphoma, Nasopharyngeal carcinoma, Oral squamous cell carcinoma, Ultraviolet, Risk estimates, Meta-analysis
      description:Increasing scientific evidence supports the link between vitamin D and cancer risk. The active metabolite 1,25(OH)2D exerts its activity by binding to the vitamin D receptor (VDR), an intracellular receptor that mediates transcriptional activation and repression of target genes. The binding of 1,25(OH)2D to VDR is able to regulate hundreds of different genes. VDR is active in virtually all tissues including the colon, breast, lung, ovary, bone, kidney, parathyroid gland, pancreatic b-cells, monocytes, T lymphocytes, melanocytes, keratinocytes, and also cancer cells. The relevance of VDR gene restriction fragment length polymorphisms for various types of cancer has been investigated by a great number of studies. We have carried out a systematic review of the literature to analyze the relevance of more VDR polymorphisms (Fok1, Bsm1, Taq1, Apa1, and Cdx2) for individual malignancies considering ethnicity as a key factor for heterogeneity. Up to December 2018, we identified 176 independent studies with data to assess the risk of breast, prostate, colorectal, skin (melanoma and non-melanoma skin cancer), lung, ovarian, kidney, bladder, gallbladder, esophageal, thyroid, head and neck, liver and pancreatic cancer, oral squamous cell carcinoma, non-Hodgkin lymphoma, multiple myeloma and sarcoma. Significant associations with VDR polymorphisms have been reported for prostate (Fok1, Bsm1, Taq1, Apa1, Cdx2), breast (Fok1, Bsm1, Taq1, Apa1, CdX2), colorectal (Fok1, Bsm1, Taq1, Apa1), and skin cancer (Fok1, Bsm1, Taq1). Very few studies reported risk estimates for the other cancer sites. Conflicting data have been reported for most malignancies, and at present, it is still not possible to make any definitive statements about the importance of the VDR genotype for cancer risk. It seems probable that other factors such as ethnicity, phenotype, 25(OH)D plasma levels, and UV radiation exposure play a role as confounding factors and introduce heterogeneity. To conclude, there is some indication that VDR polymorphisms may modulate the risk of some cancer sites and in future studies VDR genetic variation should be integrated also with assessment of vitamin D status and stratified by ethnicity.
      datePublished:2020
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Book:
      name:Sunlight, Vitamin D and Skin Cancer
      isbn:
         978-3-030-46227-7
         978-3-030-46226-0
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:IEO European Institute of Oncology IRCSS
      address:
         name:Division of Epidemiology and Biostatistics, IEO European Institute of Oncology IRCSS, Milan, Italy
         type:PostalAddress
      name:IEO European Institute of Oncology IRCSS
      address:
         name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
         type:PostalAddress
      name:IEO European Institute of Oncology IRCSS
      address:
         name:Division of Cancer Prevention and Genetics, IEO European Institute of Oncology IRCSS, Milan, Italy
         type:PostalAddress
      name:IEO European Institute of Oncology IRCSS
      address:
         name:Division of Cancer Prevention and Genetics, IEO European Institute of Oncology IRCSS, Milan, Italy
         type:PostalAddress
      name:IEO European Institute of Oncology IRCSS
      address:
         name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
         type:PostalAddress
      name:IEO European Institute of Oncology IRCSS
      address:
         name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
         type:PostalAddress
      name:IEO European Institute of Oncology IRCSS
      address:
         name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Patrizia Gnagnarella
      affiliation:
            name:IEO European Institute of Oncology IRCSS
            address:
               name:Division of Epidemiology and Biostatistics, IEO European Institute of Oncology IRCSS, Milan, Italy
               type:PostalAddress
            type:Organization
      name:Sara Raimondi
      affiliation:
            name:IEO European Institute of Oncology IRCSS
            address:
               name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
               type:PostalAddress
            type:Organization
      name:Valentina Aristarco
      affiliation:
            name:IEO European Institute of Oncology IRCSS
            address:
               name:Division of Cancer Prevention and Genetics, IEO European Institute of Oncology IRCSS, Milan, Italy
               type:PostalAddress
            type:Organization
      name:Harriet Ann Johansson
      affiliation:
            name:IEO European Institute of Oncology IRCSS
            address:
               name:Division of Cancer Prevention and Genetics, IEO European Institute of Oncology IRCSS, Milan, Italy
               type:PostalAddress
            type:Organization
      name:Federica Bellerba
      affiliation:
            name:IEO European Institute of Oncology IRCSS
            address:
               name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
               type:PostalAddress
            type:Organization
      name:Federica Corso
      affiliation:
            name:IEO European Institute of Oncology IRCSS
            address:
               name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
               type:PostalAddress
            type:Organization
      name:Sara Gandini
      affiliation:
            name:IEO European Institute of Oncology IRCSS
            address:
               name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Division of Epidemiology and Biostatistics, IEO European Institute of Oncology IRCSS, Milan, Italy
      name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
      name:Division of Cancer Prevention and Genetics, IEO European Institute of Oncology IRCSS, Milan, Italy
      name:Division of Cancer Prevention and Genetics, IEO European Institute of Oncology IRCSS, Milan, Italy
      name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
      name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
      name:Department of Experimental Oncology, IEO European Institute of Oncology IRCSS, Milan, Italy
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