We are analyzing https://link.springer.com/article/10.1007/s12253-015-9922-y.

Title:
Single Nucleotide Polymorphisms (SNPs) of RAD51-G172T and XRCC2-41657C/T Homologous Recombination Repair Genes and the Risk of Triple- Negative Breast Cancer in Polish Women | Pathology & Oncology Research
Description:
Double strand DNA breaks are the most dangerous DNA damage which, if non-repaired or misrepaired, may result in genomic instability, cancer transformation or cell death. RAD51 and XRCC2 encode proteins that are important for the repair of double-strand DNA breaks by homologous recombination. Therefore, genetic variability in these genes may contribute to the occurrence and progression of triple-negative breast cancer. The polymorphisms of the XRCC2 gene -41657C/T (rs718282) and of the RAD51 gene, −172G/T (rs1801321), were investigated by PCR-RFLP in 70 patients with triple-negative breast cancer and 70 age- and sex matched non-cancer controls. The obtained results demonstrated a significant positive association between the RAD51 T/T genotype and TNBC, with an adjusted odds ratio (OR) of 4.94 (p = 0.001). The homozygous T/T genotype was found in 60 % of TNBC cases and in 14 % of the used controls. Variant 172 T allele of RAD51 increased cancer risk (OR = 2.81 (1.72–4.58), p < .0001). No significant associations were observed between -41657C/T genotype of XRCC2 and the incidence of TNBC. There were no significant differences between the distribution of XRCC2 -41657C/T genotypes in the subgroups assigned to histological grades. The obtained results indicate that the polymorphism of RAD51, but not of XRCC2 gene, may be positively associated with the incidence of triple-negative breast carcinoma in the population of Polish women.
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Keywords {🔍}

cancer, breast, rad, pubmed, article, risk, dna, xrcc, repair, google, scholar, polymorphisms, gene, polymorphism, cas, genes, triplenegative, genotype, tnbc, polish, table, homologous, recombination, patients, role, study, analysis, data, negative, women, genetic, significant, carcinoma, triple, association, population, single, nucleotide, smolarz, breaks, doublestrand, allele, increased, observed, poland, res, central, results, cases, distribution,

Topics {✒️}

double-strand dna breaks scarf-bloom-richardson triple-negative breast cancer socalled triple-negative phenotype triple-negative breast carcinoma drinking-related laryngeal cancer double-strand breaks article download pdf single nucleotide polymorphisms single nucleotide polymorphism breast cancer patientsa dna repair gene average tumor size dna repair genes triple negative phenotype dna repair determines dna repair capacity full access brca2 mutation carriers introduction mutations dangerous dna damage privacy choices/manage cookies de hoon jp case–control study rad51 repair genes clinical-pathological features clinico-pathologic features squamous cell carcinoma dna cross-links mitotic homologous recombination breast cancer detected cancerous breast tissue human epidermal receptor-2 homologous end joining romanowicz-makowska dna repair search search breast cancer risk southern italian population california cancer registry directly bind rad51 rad51 gene family breast cancer defined breast cancer occurrence elevated tumour risk european economic area histologically-proven diagnosis hardy-weinberg equilibrium unconditional logistic regression lymph node metastases

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Single Nucleotide Polymorphisms (SNPs) of RAD51-G172T and XRCC2-41657C/T Homologous Recombination Repair Genes and the Risk of Triple- Negative Breast Cancer in Polish Women
         description:Double strand DNA breaks are the most dangerous DNA damage which, if non-repaired or misrepaired, may result in genomic instability, cancer transformation or cell death. RAD51 and XRCC2 encode proteins that are important for the repair of double-strand DNA breaks by homologous recombination. Therefore, genetic variability in these genes may contribute to the occurrence and progression of triple-negative breast cancer. The polymorphisms of the XRCC2 gene -41657C/T (rs718282) and of the RAD51 gene, −172G/T (rs1801321), were investigated by PCR-RFLP in 70 patients with triple-negative breast cancer and 70 age- and sex matched non-cancer controls. The obtained results demonstrated a significant positive association between the RAD51 T/T genotype and TNBC, with an adjusted odds ratio (OR) of 4.94 (p = 0.001). The homozygous T/T genotype was found in 60 % of TNBC cases and in 14 % of the used controls. Variant 172 T allele of RAD51 increased cancer risk (OR = 2.81 (1.72–4.58), p < .0001). No significant associations were observed between -41657C/T genotype of XRCC2 and the incidence of TNBC. There were no significant differences between the distribution of XRCC2 -41657C/T genotypes in the subgroups assigned to histological grades. The obtained results indicate that the polymorphism of RAD51, but not of XRCC2 gene, may be positively associated with the incidence of triple-negative breast carcinoma in the population of Polish women.
         datePublished:2015-03-07T00:00:00Z
         dateModified:2015-03-07T00:00:00Z
         pageStart:935
         pageEnd:940
         sameAs:https://doi.org/10.1007/s12253-015-9922-y
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             XRCC2
            Triple negative breast cancer
            Gene polymorphism
            Cancer Research
            Oncology
            Pathology
            Immunology
            Biomedicine
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         author:
               name:Magdalena M. Michalska
               affiliation:
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                     address:
                        name:Laboratory of Molecular Genetics, Department of Fetal-Maternal Medicine and Gynecology, Institute of Polish Mother’s Memorial Hospital, Lodz, Poland, Lodz, Poland
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ScholarlyArticle:
      headline:Single Nucleotide Polymorphisms (SNPs) of RAD51-G172T and XRCC2-41657C/T Homologous Recombination Repair Genes and the Risk of Triple- Negative Breast Cancer in Polish Women
      description:Double strand DNA breaks are the most dangerous DNA damage which, if non-repaired or misrepaired, may result in genomic instability, cancer transformation or cell death. RAD51 and XRCC2 encode proteins that are important for the repair of double-strand DNA breaks by homologous recombination. Therefore, genetic variability in these genes may contribute to the occurrence and progression of triple-negative breast cancer. The polymorphisms of the XRCC2 gene -41657C/T (rs718282) and of the RAD51 gene, −172G/T (rs1801321), were investigated by PCR-RFLP in 70 patients with triple-negative breast cancer and 70 age- and sex matched non-cancer controls. The obtained results demonstrated a significant positive association between the RAD51 T/T genotype and TNBC, with an adjusted odds ratio (OR) of 4.94 (p = 0.001). The homozygous T/T genotype was found in 60 % of TNBC cases and in 14 % of the used controls. Variant 172 T allele of RAD51 increased cancer risk (OR = 2.81 (1.72–4.58), p < .0001). No significant associations were observed between -41657C/T genotype of XRCC2 and the incidence of TNBC. There were no significant differences between the distribution of XRCC2 -41657C/T genotypes in the subgroups assigned to histological grades. The obtained results indicate that the polymorphism of RAD51, but not of XRCC2 gene, may be positively associated with the incidence of triple-negative breast carcinoma in the population of Polish women.
      datePublished:2015-03-07T00:00:00Z
      dateModified:2015-03-07T00:00:00Z
      pageStart:935
      pageEnd:940
      sameAs:https://doi.org/10.1007/s12253-015-9922-y
      keywords:
          RAD51
          XRCC2
         Triple negative breast cancer
         Gene polymorphism
         Cancer Research
         Oncology
         Pathology
         Immunology
         Biomedicine
         general
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            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Magdalena M. Michalska
            affiliation:
                  name:Regional Hospital in Kalisz
                  address:
                     name:Department of Obstetrics and Gynaecology, Regional Hospital in Kalisz, Kalisz, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dariusz Samulak
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                  name:Regional Hospital in Kalisz
                  address:
                     name:Department of Obstetrics and Gynaecology, Regional Hospital in Kalisz, Kalisz, Poland
                     type:PostalAddress
                  type:Organization
                  name:Poznan University of Medical Sciences
                  address:
                     name:Cathedral of Mother’s and Child’s Health, Poznan University of Medical Sciences, Poznań, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hanna Romanowicz
            affiliation:
                  name:Regional Hospital in Glowno
                  address:
                     name:High School of Informatics, Regional Hospital in Glowno, Glowno, Poland
                     type:PostalAddress
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            type:Person
            name:Beata Smolarz
            affiliation:
                  name:Institute of Polish Mother’s Memorial Hospital, Lodz, Poland
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                     name:Laboratory of Molecular Genetics, Department of Fetal-Maternal Medicine and Gynecology, Institute of Polish Mother’s Memorial Hospital, Lodz, Poland, Lodz, Poland
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         name:Department of Obstetrics and Gynaecology, Regional Hospital in Kalisz, Kalisz, Poland
         type:PostalAddress
      name:Poznan University of Medical Sciences
      address:
         name:Cathedral of Mother’s and Child’s Health, Poznan University of Medical Sciences, Poznań, Poland
         type:PostalAddress
      name:Regional Hospital in Glowno
      address:
         name:High School of Informatics, Regional Hospital in Glowno, Glowno, Poland
         type:PostalAddress
      name:Institute of Polish Mother’s Memorial Hospital, Lodz, Poland
      address:
         name:Laboratory of Molecular Genetics, Department of Fetal-Maternal Medicine and Gynecology, Institute of Polish Mother’s Memorial Hospital, Lodz, Poland, Lodz, Poland
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            address:
               name:Department of Obstetrics and Gynaecology, Regional Hospital in Kalisz, Kalisz, Poland
               type:PostalAddress
            type:Organization
      name:Dariusz Samulak
      affiliation:
            name:Regional Hospital in Kalisz
            address:
               name:Department of Obstetrics and Gynaecology, Regional Hospital in Kalisz, Kalisz, Poland
               type:PostalAddress
            type:Organization
            name:Poznan University of Medical Sciences
            address:
               name:Cathedral of Mother’s and Child’s Health, Poznan University of Medical Sciences, Poznań, Poland
               type:PostalAddress
            type:Organization
      name:Hanna Romanowicz
      affiliation:
            name:Regional Hospital in Glowno
            address:
               name:High School of Informatics, Regional Hospital in Glowno, Glowno, Poland
               type:PostalAddress
            type:Organization
      name:Beata Smolarz
      affiliation:
            name:Institute of Polish Mother’s Memorial Hospital, Lodz, Poland
            address:
               name:Laboratory of Molecular Genetics, Department of Fetal-Maternal Medicine and Gynecology, Institute of Polish Mother’s Memorial Hospital, Lodz, Poland, Lodz, Poland
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Obstetrics and Gynaecology, Regional Hospital in Kalisz, Kalisz, Poland
      name:Department of Obstetrics and Gynaecology, Regional Hospital in Kalisz, Kalisz, Poland
      name:Cathedral of Mother’s and Child’s Health, Poznan University of Medical Sciences, Poznań, Poland
      name:High School of Informatics, Regional Hospital in Glowno, Glowno, Poland
      name:Laboratory of Molecular Genetics, Department of Fetal-Maternal Medicine and Gynecology, Institute of Polish Mother’s Memorial Hospital, Lodz, Poland, Lodz, Poland

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