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We began analyzing https://www.nature.com/articles/6691458, but it redirected us to https://www.nature.com/articles/6691458. The analysis below is for the second page.

Title[redir]:
Molecular cytogenetic analysis of breast cancer cell lines | British Journal of Cancer
Description:
The extensive chromosome rearrangements of breast carcinomas must contribute to tumour development, but have been largely intractable to classical cytogenetic banding. We report here the analysis by 24-colour karyotyping and comparative genomic hybridization (CGH) of 19 breast carcinoma cell lines and one normal breast epithelial cell line, which provide model examples of karyotype patterns and translocations present in breast carcinomas. The CGH was compared with CGH of 106 primary breast cancers. The lines varied from perfectly diploid to highly aneuploid. Translocations were very varied and over 98% were unbalanced. The most frequent in the carcinomas were 8;11 in five lines; and 8;17, 1;4 and 1;10 in four lines. The most frequently involved chromosome was 8. Several lines showed complex multiply-translocated chromosomes. The very aneuploid karyotypes appeared to fall into two groups that evolved by different routes: one that steadily lost chromosomes and at one point doubled their entire karyotype; and another that steadily gained chromosomes, together with abnormalities. All karyotypes fell within the range seen in fresh material and CGH confirmed that the lines were broadly representative of fresh tumours. The karyotypes provide a resource for the cataloguing and analysis of translocations in these tumours, accessible at http://www.path.cam.ac.uk/~pawefish . © 2000 Cancer Research Campaign

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Keywords {🔍}

cancer, article, breast, google, scholar, cas, nature, cell, lines, chromosomes, human, analysis, chromosome, genes, karyotyping, content, genomic, res, cytogenetic, cookies, comparative, hybridization, research, chromosomal, spectral, kallioniemi, privacy, data, open, molecular, carcinomas, tumour, cgh, carcinoma, line, translocations, karyotypes, dutrillaux, journal, access, theillet, edwards, karyotype, primary, tumours, evolution, pubmed, dna, treatment, cells,

Topics {✒️}

nature portfolio privacy policy val d'aurelle-paul larmarque nature genetics 12 nature genetics 15 advertising nature tumour development social media 0/ reprints combinatorial multi-fluor fish human tumor cells permissions comparative genomic hybridization polish women magdalena tumorigenic cell line personal data human epithelial cancers human breast adenocarcinoma chromosomal evolution breast tumour nuclei data protection karyotype patterns extensive chromosome rearrangements frequently involved chromosome chromosome banding studies privacy single-cell sequencing karyotyping human chromosomes primary breast cancer reverse chromosome painting haematological malignancies detected hidden chromosome abnormalities journals search log dna content chromosomal translocation fusing clonal chromosome abnormalities aneuploid karyotypes appeared normal karyotype derived stem cell characteristics steadily lost chromosomes steadily gained chromosomes genomic dna resolves hgl/nrg1 genes european economic area explore content classical cytogenetic banding lymph node metastases fgfr1 coamplification results le francois dez

Questions {❓}

Heim S (1996) Clonal chromosome abnormalities in neoplastic cells: evidence of genetic instability?

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WebPage:
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         description:The extensive chromosome rearrangements of breast carcinomas must contribute to tumour development, but have been largely intractable to classical cytogenetic banding. We report here the analysis by 24-colour karyotyping and comparative genomic hybridization (CGH) of 19 breast carcinoma cell lines and one normal breast epithelial cell line, which provide model examples of karyotype patterns and translocations present in breast carcinomas. The CGH was compared with CGH of 106 primary breast cancers. The lines varied from perfectly diploid to highly aneuploid. Translocations were very varied and over 98% were unbalanced. The most frequent in the carcinomas were 8;11 in five lines; and 8;17, 1;4 and 1;10 in four lines. The most frequently involved chromosome was 8. Several lines showed complex multiply-translocated chromosomes. The very aneuploid karyotypes appeared to fall into two groups that evolved by different routes: one that steadily lost chromosomes and at one point doubled their entire karyotype; and another that steadily gained chromosomes, together with abnormalities. All karyotypes fell within the range seen in fresh material and CGH confirmed that the lines were broadly representative of fresh tumours. The karyotypes provide a resource for the cataloguing and analysis of translocations in these tumours, accessible at http://www.path.cam.ac.uk/~pawefish . Â© 2000 Cancer Research Campaign
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      headline:Molecular cytogenetic analysis of breast cancer cell lines
      description:The extensive chromosome rearrangements of breast carcinomas must contribute to tumour development, but have been largely intractable to classical cytogenetic banding. We report here the analysis by 24-colour karyotyping and comparative genomic hybridization (CGH) of 19 breast carcinoma cell lines and one normal breast epithelial cell line, which provide model examples of karyotype patterns and translocations present in breast carcinomas. The CGH was compared with CGH of 106 primary breast cancers. The lines varied from perfectly diploid to highly aneuploid. Translocations were very varied and over 98% were unbalanced. The most frequent in the carcinomas were 8;11 in five lines; and 8;17, 1;4 and 1;10 in four lines. The most frequently involved chromosome was 8. Several lines showed complex multiply-translocated chromosomes. The very aneuploid karyotypes appeared to fall into two groups that evolved by different routes: one that steadily lost chromosomes and at one point doubled their entire karyotype; and another that steadily gained chromosomes, together with abnormalities. All karyotypes fell within the range seen in fresh material and CGH confirmed that the lines were broadly representative of fresh tumours. The karyotypes provide a resource for the cataloguing and analysis of translocations in these tumours, accessible at http://www.path.cam.ac.uk/~pawefish . Â© 2000 Cancer Research Campaign
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         chromosome translocations
         karyotypes
         fluorescence-in situ hybridization
         spectral karyotyping
         comparative genomic hybridization
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         Cancer Research
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         Molecular Medicine
         Oncology
         Drug Resistance
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