We are analyzing https://link.springer.com/article/10.1007/s12026-022-09353-1.

Title:
Regulation of effector and memory CD8 + T cell differentiation: a focus on orphan nuclear receptor NR4A family, transcription factor, and metabolism | Immunologic Research
Description:
Abstract CD8 + T cells undergo rapid expansion followed by contraction and the development of memory cells after their receptors are activated. The development of immunological memory following acute infection is a complex phenomenon that involves several molecular, transcriptional, and metabolic mechanisms. As memory cells confer long-term protection and respond to secondary stimulation with strong effector function, understanding the mechanisms that influence their development is of great importance. Orphan nuclear receptors, NR4As, are immediate early genes that function as transcription factors and bind with the NBRE region of chromatin. Interestingly, the NBRE region of activated CD8 + T cells is highly accessible at the same time the expression of NR4As is induced. This suggests a potential role of NR4As in the early events post T cell activation that determines cell fate decisions. In this review, we will discuss the influence of NR4As on the differentiation of CD8 + T cells during the immune response to acute infection and the development of immunological memory. We will also discuss the signals, transcription factors, and metabolic mechanisms that control cell fate decisions. Highlights Memory CD8 + T cells are an essential subset that mediates long-term protection after pathogen encounters. Some specific environmental cues, transcriptional factors, and metabolic pathways regulate the differentiation of CD8 + T cells and the development of memory cells. Orphan nuclear receptor NR4As are early genes that act as transcription factors and are highly expressed post-T cell receptor activation. NR4As influence the effector function and differentiation of CD8 + T cells and also control the development of immunological memory following acute infection.
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Keywords {🔍}

pubmed, article, google, scholar, cas, cell, memory, cells, central, immunol, differentiation, effector, transcription, nat, factor, immunity, receptor, development, infection, nuclear, factors, rev, nature, sci, transcriptional, kaech, expression, tcell, function, orphan, nra, irf, wherry, regulates, regulation, signaling, httpsdoiorgni, httpsdoiorgjimmuni, httpsdoiorgjimmunol, expansion, acad, nras, response, regulatory, ahmed, med, science, viral, proc, natl,

Topics {✒️}

month download article/chapter transcription factors t-bet t-bet transcription factor t-cell hybrid require mediates long-term protection single-cell rna sequencing short-lived effector cd8 short-lived effector cd8+ decreased t-bet expression t-helper-cell differentiation orphan nuclear receptors core-binding factor β long-term memory cd4+ cells lacking t-bet nuclear hormone receptors cytokine-induced biologic responses memory t-cell differentiation curtailed t-cell response interleukin-21–interleukin-10–stat3 pathway long-lived memory cells central memory cd8 + il-2high tissue-resident scott-browne jp monocyte-derived dendritic cells dna-binding inhibitor id3 control tissue-resident memory t-cell receptor full article pdf central-memory phenotype cd8+ tissue-resident memory tissue-resident memory cd8+ t-bet-independent il-12 enhances effector transcription factors runx3 joshi ns irf4 transcription factors cytokines tgf-β interferon regulatory factors antigen receptor signaling human tissue-resident memory transcription factor irf4 related subjects adaptive immune responses cell receptor activation antigen exposure history jordan-williams kl van deursen jm privacy choices/manage cookies central memory inflammation-induced death

Schema {🗺️}

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         headline:Regulation of effector and memory CD8 + T cell differentiation: a focus on orphan nuclear receptor NR4A family, transcription factor, and metabolism
         description:CD8 + T cells undergo rapid expansion followed by contraction and the development of memory cells after their receptors are activated. The development of immunological memory following acute infection is a complex phenomenon that involves several molecular, transcriptional, and metabolic mechanisms. As memory cells confer long-term protection and respond to secondary stimulation with strong effector function, understanding the mechanisms that influence their development is of great importance. Orphan nuclear receptors, NR4As, are immediate early genes that function as transcription factors and bind with the NBRE region of chromatin. Interestingly, the NBRE region of activated CD8 + T cells is highly accessible at the same time the expression of NR4As is induced. This suggests a potential role of NR4As in the early events post T cell activation that determines cell fate decisions. In this review, we will discuss the influence of NR4As on the differentiation of CD8 + T cells during the immune response to acute infection and the development of immunological memory. We will also discuss the signals, transcription factors, and metabolic mechanisms that control cell fate decisions.
         datePublished:2022-12-26T00:00:00Z
         dateModified:2022-12-26T00:00:00Z
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         pageEnd:327
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            NR4A nuclear receptor
            Transcription factors
            Acute infection
            Differentiation
            Immunology
            Allergology
            Medicine/Public Health
            general
            Internal Medicine
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      headline:Regulation of effector and memory CD8 + T cell differentiation: a focus on orphan nuclear receptor NR4A family, transcription factor, and metabolism
      description:CD8 + T cells undergo rapid expansion followed by contraction and the development of memory cells after their receptors are activated. The development of immunological memory following acute infection is a complex phenomenon that involves several molecular, transcriptional, and metabolic mechanisms. As memory cells confer long-term protection and respond to secondary stimulation with strong effector function, understanding the mechanisms that influence their development is of great importance. Orphan nuclear receptors, NR4As, are immediate early genes that function as transcription factors and bind with the NBRE region of chromatin. Interestingly, the NBRE region of activated CD8 + T cells is highly accessible at the same time the expression of NR4As is induced. This suggests a potential role of NR4As in the early events post T cell activation that determines cell fate decisions. In this review, we will discuss the influence of NR4As on the differentiation of CD8 + T cells during the immune response to acute infection and the development of immunological memory. We will also discuss the signals, transcription factors, and metabolic mechanisms that control cell fate decisions.
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      dateModified:2022-12-26T00:00:00Z
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      pageEnd:327
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         Immunological memory
         NR4A nuclear receptor
         Transcription factors
         Acute infection
         Differentiation
         Immunology
         Allergology
         Medicine/Public Health
         general
         Internal Medicine
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      name:College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
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