We are analyzing https://link.springer.com/article/10.1007/s12026-015-8693-6.

Title:
Molecular studies of lupus nephritis kidneys | Immunologic Research
Description:
Lupus nephritis is a devastating complication of systemic lupus erythematosus (SLE) for which current therapies are insufficiently effective. Histologic evaluation of renal biopsies is a poor predictor of therapeutic response or outcome. Integrated immunologic, genomic and proteomic approaches may yield new insights into disease pathogenesis and thereby improve therapeutic strategies for lupus nephritis. Given the lack of sequential biopsies from humans, it also remains essential to study informative animal models of disease. Cross-species analyses can identify cells or pathways that are relevant to human disease and can be further studied in mouse models. Using a systems biology approach in which we compare molecular data from kidneys of three different mouse models of lupus nephritis with data from human lupus biopsies, we have found that inflammatory events escalate rapidly around the time of proteinuria onset. This is followed by hypoxia and metabolic stress, and by tubular and endothelial dysfunction. The failure of complete reversal of these abnormalities may increase the sensitivity of the kidney to further insult. We further found that renal macrophages and dendritic cells are key players in lupus nephritis both in mouse models and humans and that macrophages display a hybrid molecular profile that reflects incomplete resolution of inflammation and excessive tissue remodeling. Finally, our studies have suggested several new biomarkers for disease stage that can now be tested longitudinally in human SLE patients.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Non-Profit & Charity

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

pubmed, article, google, scholar, cas, lupus, nephritis, central, kidney, renal, immunol, systemic, dendritic, erythematosus, disease, cells, bethunaickan, human, int, murine, macrophages, davidson, models, research, berthier, mice, arthritis, mouse, glomerulonephritis, nephrol, ramanujam, huang, liu, cell, zhang, sle, biomarkers, rheumatol, clin, schiffer, wang, macrophage, injury, privacy, cookies, content, data, access, rheum, subsets,

Topics {✒️}

month download article/chapter rna-related antigens due experimental renal inflammation—part freire-de-lima cg cross-species analyses single-cell rna sequencing kidney ischemia-reperfusion injury mononuclear phagocyte system full article pdf systemic lupus erythematosus shared regulatory networks lupus nephritis kidneys proliferative lupus nephritis privacy choices/manage cookies hybrid molecular profile lupus research institute comparative transcriptional profiling severe lupus nephritis lupus nephritis flare human lupus nephritis t-cell responses human macrophage activation murine lupus nephritis lupus nephritis flares sle nephritis reveals immune complex formation tlr7 gene duplication musculoskeletal diseases human renal tissue related subjects transcriptional regulatory pathways compare molecular data article davidson excessive tissue remodeling de fijter jw lupher ml jr rose ce jr stage-specific genes local macrophage proliferation physiol renal physiol curr opin rheumatol european economic area systems biology approach short term administration ctla4ig prevents initiation anti-phospholipid syndrome holdsworth sr hamilton-williams ee gene-expression profiles chemokine receptors ccr2

Questions {❓}

The kidney biopsy in lupus nephritis: is it still relevant?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Molecular studies of lupus nephritis kidneys
         description:Lupus nephritis is a devastating complication of systemic lupus erythematosus (SLE) for which current therapies are insufficiently effective. Histologic evaluation of renal biopsies is a poor predictor of therapeutic response or outcome. Integrated immunologic, genomic and proteomic approaches may yield new insights into disease pathogenesis and thereby improve therapeutic strategies for lupus nephritis. Given the lack of sequential biopsies from humans, it also remains essential to study informative animal models of disease. Cross-species analyses can identify cells or pathways that are relevant to human disease and can be further studied in mouse models. Using a systems biology approach in which we compare molecular data from kidneys of three different mouse models of lupus nephritis with data from human lupus biopsies, we have found that inflammatory events escalate rapidly around the time of proteinuria onset. This is followed by hypoxia and metabolic stress, and by tubular and endothelial dysfunction. The failure of complete reversal of these abnormalities may increase the sensitivity of the kidney to further insult. We further found that renal macrophages and dendritic cells are key players in lupus nephritis both in mouse models and humans and that macrophages display a hybrid molecular profile that reflects incomplete resolution of inflammation and excessive tissue remodeling. Finally, our studies have suggested several new biomarkers for disease stage that can now be tested longitudinally in human SLE patients.
         datePublished:2015-09-16T00:00:00Z
         dateModified:2015-09-16T00:00:00Z
         pageStart:187
         pageEnd:196
         sameAs:https://doi.org/10.1007/s12026-015-8693-6
         keywords:
            Lupus
            Nephritis
            Macrophages
            Inflammation
            Biomarkers
            Immunology
            Allergology
            Medicine/Public Health
            general
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12026-015-8693-6/MediaObjects/12026_2015_8693_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12026-015-8693-6/MediaObjects/12026_2015_8693_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12026-015-8693-6/MediaObjects/12026_2015_8693_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12026-015-8693-6/MediaObjects/12026_2015_8693_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12026-015-8693-6/MediaObjects/12026_2015_8693_Fig5_HTML.gif
         isPartOf:
            name:Immunologic Research
            issn:
               1559-0755
               0257-277X
            volumeNumber:63
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Anne Davidson
               affiliation:
                     name:Feinstein Institute for Medical Research
                     address:
                        name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Ramalingam Bethunaickan
               affiliation:
                     name:Feinstein Institute for Medical Research
                     address:
                        name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Celine Berthier
               affiliation:
                     name:University of Michigan
                     address:
                        name:Department of Internal Medicine, Nephrology, University of Michigan, Ann Arbor, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ranjit Sahu
               affiliation:
                     name:Feinstein Institute for Medical Research
                     address:
                        name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Weijia Zhang
               affiliation:
                     name:Mount Sinai Medical Center
                     address:
                        name:Department of Medicine, Mount Sinai Medical Center, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Matthias Kretzler
               affiliation:
                     name:University of Michigan
                     address:
                        name:Department of Internal Medicine, Nephrology, University of Michigan, Ann Arbor, USA
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Molecular studies of lupus nephritis kidneys
      description:Lupus nephritis is a devastating complication of systemic lupus erythematosus (SLE) for which current therapies are insufficiently effective. Histologic evaluation of renal biopsies is a poor predictor of therapeutic response or outcome. Integrated immunologic, genomic and proteomic approaches may yield new insights into disease pathogenesis and thereby improve therapeutic strategies for lupus nephritis. Given the lack of sequential biopsies from humans, it also remains essential to study informative animal models of disease. Cross-species analyses can identify cells or pathways that are relevant to human disease and can be further studied in mouse models. Using a systems biology approach in which we compare molecular data from kidneys of three different mouse models of lupus nephritis with data from human lupus biopsies, we have found that inflammatory events escalate rapidly around the time of proteinuria onset. This is followed by hypoxia and metabolic stress, and by tubular and endothelial dysfunction. The failure of complete reversal of these abnormalities may increase the sensitivity of the kidney to further insult. We further found that renal macrophages and dendritic cells are key players in lupus nephritis both in mouse models and humans and that macrophages display a hybrid molecular profile that reflects incomplete resolution of inflammation and excessive tissue remodeling. Finally, our studies have suggested several new biomarkers for disease stage that can now be tested longitudinally in human SLE patients.
      datePublished:2015-09-16T00:00:00Z
      dateModified:2015-09-16T00:00:00Z
      pageStart:187
      pageEnd:196
      sameAs:https://doi.org/10.1007/s12026-015-8693-6
      keywords:
         Lupus
         Nephritis
         Macrophages
         Inflammation
         Biomarkers
         Immunology
         Allergology
         Medicine/Public Health
         general
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12026-015-8693-6/MediaObjects/12026_2015_8693_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12026-015-8693-6/MediaObjects/12026_2015_8693_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12026-015-8693-6/MediaObjects/12026_2015_8693_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12026-015-8693-6/MediaObjects/12026_2015_8693_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12026-015-8693-6/MediaObjects/12026_2015_8693_Fig5_HTML.gif
      isPartOf:
         name:Immunologic Research
         issn:
            1559-0755
            0257-277X
         volumeNumber:63
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Anne Davidson
            affiliation:
                  name:Feinstein Institute for Medical Research
                  address:
                     name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Ramalingam Bethunaickan
            affiliation:
                  name:Feinstein Institute for Medical Research
                  address:
                     name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Celine Berthier
            affiliation:
                  name:University of Michigan
                  address:
                     name:Department of Internal Medicine, Nephrology, University of Michigan, Ann Arbor, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ranjit Sahu
            affiliation:
                  name:Feinstein Institute for Medical Research
                  address:
                     name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Weijia Zhang
            affiliation:
                  name:Mount Sinai Medical Center
                  address:
                     name:Department of Medicine, Mount Sinai Medical Center, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Matthias Kretzler
            affiliation:
                  name:University of Michigan
                  address:
                     name:Department of Internal Medicine, Nephrology, University of Michigan, Ann Arbor, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Immunologic Research
      issn:
         1559-0755
         0257-277X
      volumeNumber:63
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Feinstein Institute for Medical Research
      address:
         name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
         type:PostalAddress
      name:Feinstein Institute for Medical Research
      address:
         name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
         type:PostalAddress
      name:University of Michigan
      address:
         name:Department of Internal Medicine, Nephrology, University of Michigan, Ann Arbor, USA
         type:PostalAddress
      name:Feinstein Institute for Medical Research
      address:
         name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
         type:PostalAddress
      name:Mount Sinai Medical Center
      address:
         name:Department of Medicine, Mount Sinai Medical Center, New York, USA
         type:PostalAddress
      name:University of Michigan
      address:
         name:Department of Internal Medicine, Nephrology, University of Michigan, Ann Arbor, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Anne Davidson
      affiliation:
            name:Feinstein Institute for Medical Research
            address:
               name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Ramalingam Bethunaickan
      affiliation:
            name:Feinstein Institute for Medical Research
            address:
               name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
               type:PostalAddress
            type:Organization
      name:Celine Berthier
      affiliation:
            name:University of Michigan
            address:
               name:Department of Internal Medicine, Nephrology, University of Michigan, Ann Arbor, USA
               type:PostalAddress
            type:Organization
      name:Ranjit Sahu
      affiliation:
            name:Feinstein Institute for Medical Research
            address:
               name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
               type:PostalAddress
            type:Organization
      name:Weijia Zhang
      affiliation:
            name:Mount Sinai Medical Center
            address:
               name:Department of Medicine, Mount Sinai Medical Center, New York, USA
               type:PostalAddress
            type:Organization
      name:Matthias Kretzler
      affiliation:
            name:University of Michigan
            address:
               name:Department of Internal Medicine, Nephrology, University of Michigan, Ann Arbor, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
      name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
      name:Department of Internal Medicine, Nephrology, University of Michigan, Ann Arbor, USA
      name:Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, New York, USA
      name:Department of Medicine, Mount Sinai Medical Center, New York, USA
      name:Department of Internal Medicine, Nephrology, University of Michigan, Ann Arbor, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(271)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.27s.

LINK . SPRINGER . COM {}