We are analyzing https://link.springer.com/article/10.1007/s10911-007-9047-3.

Title:
Organotropism of Breast Cancer Metastasis | Journal of Mammary Gland Biology and Neoplasia
Description:
Breast cancer causes mortality by metastasizing to a variety of vital organs, such as bone, lung, brain and liver. Effective therapeutic intervention of this deadly process relies on a better mechanistic understanding of metastasis organotropism. Recent studies have confirmed earlier speculations that metastasis is a non-random process and is dependent on intricate tumor-stroma interactions at the target organ. Both the intrinsic properties of breast cancer cells and the host organ microenvironment are important in determining the efficiency of organ-specific metastasis. Advances in animal modeling, in vivo imaging and functional genomics have accelerated the discovery of important molecular mediators of organ-specific metastasis. A conceptual framework of breast cancer organotropism is emerging and will be instrumental in guiding future efforts in this exciting research field.
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Keywords {🔍}

cancer, article, google, scholar, pubmed, cas, metastasis, breast, cell, bone, cells, factor, growth, nature, mammary, res, kang, stem, human, tumor, gland, nat, metastases, brain, niche, metastatic, rev, usa, research, organotropism, lung, clin, biol, privacy, cookies, content, journal, biology, molecular, access, protein, gupta, analysis, publish, search, neoplasia, yibin, liver, microenvironment, vivo,

Topics {✒️}

month download article/chapter parathyroid hormone-related protein astrocyte-derived cytokines contribute bone-seeking clone exhibits organ-specific metastasis tgf beta mediated breast cancer metastasis mediates lung metastasis human breast cancer breast cancer organotropism mammary-specific deletion related subjects breast cancer cells intricate tumor-stroma interactions cancer stem cells promoting pulmonary metastasis cancer stem cell full article pdf studying cancer metastasis pre-metastatic niche mammary gland biology initiating tumour growth host organ microenvironment cancerous stem cells single stem cell privacy choices/manage cookies cell surface protein van wijnen aj article lu nuclear factor kappa successive tumour lines mouse mammary tumor human brain tumors normal mammary gland brain-seeking clone american cancer society pro-metastasis function tumor cell surface single tumor cell functional mammary gland metastasis organotropism fidler ij cancer cell migration osteoblastic cells regulate yibin kang exciting research field check access instant access mammary gland development controls cell invasion

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         description:Breast cancer causes mortality by metastasizing to a variety of vital organs, such as bone, lung, brain and liver. Effective therapeutic intervention of this deadly process relies on a better mechanistic understanding of metastasis organotropism. Recent studies have confirmed earlier speculations that metastasis is a non-random process and is dependent on intricate tumor-stroma interactions at the target organ. Both the intrinsic properties of breast cancer cells and the host organ microenvironment are important in determining the efficiency of organ-specific metastasis. Advances in animal modeling, in vivo imaging and functional genomics have accelerated the discovery of important molecular mediators of organ-specific metastasis. A conceptual framework of breast cancer organotropism is emerging and will be instrumental in guiding future efforts in this exciting research field.
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