We are analyzing https://link.springer.com/article/10.1007/s10555-023-10149-4.

Title:
Clonal tracking in cancer and metastasis | Cancer and Metastasis Reviews
Description:
The eradication of many cancers has proven challenging due to the presence of functionally and genetically heterogeneous clones maintained by rare cancer stem cells (CSCs), which contribute to disease progression, treatment refractoriness, and late relapse. The characterization of functional CSC activity has necessitated the development of modern clonal tracking strategies. This review describes viral-based and CRISPR-Cas9-based cellular barcoding, lineage tracing, and imaging-based approaches. DNA-based cellular barcoding technology is emerging as a powerful and robust strategy that has been widely applied to in vitro and in vivo model systems, including patient-derived xenograft models. This review also highlights the potential of these methods for use in the clinical and drug discovery contexts and discusses the important insights gained from such approaches. Graphical Abstract
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Keywords {🔍}

pubmed, article, google, scholar, cas, central, cancer, nature, cell, stem, cells, clonal, barcoding, lineage, human, singlecell, analysis, van, tracking, cellular, medicine, science, molecular, dynamics, nguyen, tracing, breast, dna, sequencing, tumor, evolution, wang, reviews, methods, leukemia, reveals, therapy, kannan, vivo, genetic, growth, gene, mice, states, blood, data, journal, research, heterogeneity, hematopoietic,

Topics {✒️}

crispr/cas9/cas12/cas13/cas14 proteins utilized cd40-based immuno-chemotherapy combination crispr/cas9-based genome editing crispr-cas9-based cellular barcoding month download article/chapter human colon-cancer-initiating cells cre-recombinase-driven polylox barcoding crispr-cas9-induced genetic scars review describes viral-based fluorescent multi-clonal tracking long-term multilineage engraftment plasma cell-free dna tumor clone-initiating cells lineage-specific gene expression reversible transcriptomic profile single-stem-cell level single-cell analyses define single-cell cancer genomes double-strand breaks induced sequential small-molecule fluorescent single-cell lineage tracing single-clone tracking gene expression profiles imaging-based approaches pre-existing functional heterogeneity simultaneous single-cell profiling long viet nguyen single-cell lineages reveal high dna specificity cell-free dna minute chromosome human glioblastoma reveals full article pdf cancer stem cells initiating tumour growth cellular barcoding tool single-cell sequencing early haematopoietic progenitors single-cell resolution nagarajan kannan studying clonal dynamics decipher clonal dynamics acute myeloid leukemia crispr-cas9 leads crispr-cas9 nucleases counting stem cells crispra-inducible reporters primitive hematopoietic cell cell stem cell article aalam

Questions {❓}

Tackling the cancer stem cells - what challenges do they pose?

Schema {🗺️}

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         description:The eradication of many cancers has proven challenging due to the presence of functionally and genetically heterogeneous clones maintained by rare cancer stem cells (CSCs), which contribute to disease progression, treatment refractoriness, and late relapse. The characterization of functional CSC activity has necessitated the development of modern clonal tracking strategies. This review describes viral-based and CRISPR-Cas9-based cellular barcoding, lineage tracing, and imaging-based approaches. DNA-based cellular barcoding technology is emerging as a powerful and robust strategy that has been widely applied to in vitro and in vivo model systems, including patient-derived xenograft models. This review also highlights the potential of these methods for use in the clinical and drug discovery contexts and discusses the important insights gained from such approaches.
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