We are analyzing https://link.springer.com/article/10.1007/s10555-019-09815-3.

Title:
Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment | Cancer and Metastasis Reviews
Description:
The prostate-specific antigen (PSA) blood test is the accepted biomarker of tumor recurrence. PSA levels in serum correlate with disease progression, though its diagnostic accuracy is questionable. As a result, significant progress has been made in developing modified PSA tests such as PSA velocity, PSA density, 4Kscore, PSA glycoprofiling, Prostate Health Index, and the STHLM3 test. PSA, a serine protease, is secreted from the epithelial cells of the prostate. PSA has been suggested as a molecular target for prostate cancer therapy due to the fact that it is not only active in prostate tissue but also has a pivotal role on prostate cancer signaling pathways including proliferation, invasion, metastasis, angiogenesis, apoptosis, immune response, and tumor microenvironment regulation. Here, we summarize the current standing of PSA in prostate cancer progression as well as its utility in prostate cancer therapeutic approaches with an emphasis on the role of PSA in the tumor microenvironment.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

pubmed, google, scholar, article, cancer, prostate, cas, antigen, prostatespecific, central, journal, psa, human, chemistry, research, clinical, kallikrein, httpsdoiorg, kallikreinrelated, biological, therapy, urology, clements, expression, denmeade, klk, tumor, cells, specific, httpsdoiorgs, httpsdoiorgpros, oncology, cell, metastasis, role, batra, molecular, biomarkers, zhang, peptidases, serine, lilja, prostatic, nature, bone, medicinal, prodrug, european, reviews, srinivasan,

Topics {✒️}

month download article/chapter judith clements & jyotsna batra prostate-specific kallikrein-related peptidases bfgf-mediated angiogenic response hormone-refractory prostate cancer kallikrein-related peptidase family peptide-doxorubicin ‘prodrug’ activated kallikrein-related peptidase genes prostate-specific antigen modulates tissue-specific adenovirus vector free prostate-specific antigen pro-prostate-specific antigen free-prostate-specific antigen prostate-specific antigen relapse prostate-specific antigen velocity targeting kallikrein-related peptidases pthrp-stimulated camp accumulation prostate-specific antigen glycoprofiling human kallikrein-related peptidases microrna-3162-5p-mediated crosstalk immune response kallikrein-related peptidase 7 kallikrein-related peptidase 2 anti-cd3 bispecific antibody anti-psa-igg conjugated free/total psa ratio immune-mediated eradication seminal vesicle-secreted proteins prostate-specific antigen prostate specific antigen jyotsna batra full article pdf peptide-based inhibitors peptide-drug conjugate psa-alpha-2-macroglobulin complex kallikrein-related peptidases kallikrein-related peptidases 6 targeted imaging agents prostate-specific targeting tissue kallikrein family author information authors population-based cohort privacy choices/manage cookies prostate tumor growth prostate cancer microenvironment albumin-binding prodrug induces cell death prostate cancer cells related subjects prostate cancer metastatic

Questions {❓}

Can we preoperatively identify men who are at high risk for aggressive prostate cancer?
Does PSA velocity predict prostate cancer in pre-screened populations?
Smarter screening for prostate cancer: for the few, not the many?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment
         description:The prostate-specific antigen (PSA) blood test is the accepted biomarker of tumor recurrence. PSA levels in serum correlate with disease progression, though its diagnostic accuracy is questionable. As a result, significant progress has been made in developing modified PSA tests such as PSA velocity, PSA density, 4Kscore, PSA glycoprofiling, Prostate Health Index, and the STHLM3 test. PSA, a serine protease, is secreted from the epithelial cells of the prostate. PSA has been suggested as a molecular target for prostate cancer therapy due to the fact that it is not only active in prostate tissue but also has a pivotal role on prostate cancer signaling pathways including proliferation, invasion, metastasis, angiogenesis, apoptosis, immune response, and tumor microenvironment regulation. Here, we summarize the current standing of PSA in prostate cancer progression as well as its utility in prostate cancer therapeutic approaches with an emphasis on the role of PSA in the tumor microenvironment.
         datePublished:2019-10-28T00:00:00Z
         dateModified:2019-10-28T00:00:00Z
         pageStart:333
         pageEnd:346
         sameAs:https://doi.org/10.1007/s10555-019-09815-3
         keywords:
            Prostate-specific antigen
            Prostate cancer
            Kallikrein-related peptidase
            Angiogenesis
            Immune response
            Cancer Research
            Oncology
            Biomedicine
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-019-09815-3/MediaObjects/10555_2019_9815_Fig1_HTML.png
         isPartOf:
            name:Cancer and Metastasis Reviews
            issn:
               1573-7233
               0167-7659
            volumeNumber:38
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Afshin Moradi
               affiliation:
                     name:Queensland University of Technology
                     address:
                        name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
                        type:PostalAddress
                     type:Organization
                     name:Queensland University of Technology
                     address:
                        name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Srilakshmi Srinivasan
               affiliation:
                     name:Queensland University of Technology
                     address:
                        name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
                        type:PostalAddress
                     type:Organization
                     name:Queensland University of Technology
                     address:
                        name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Judith Clements
               affiliation:
                     name:Queensland University of Technology
                     address:
                        name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
                        type:PostalAddress
                     type:Organization
                     name:Queensland University of Technology
                     address:
                        name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jyotsna Batra
               affiliation:
                     name:Queensland University of Technology
                     address:
                        name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
                        type:PostalAddress
                     type:Organization
                     name:Queensland University of Technology
                     address:
                        name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment
      description:The prostate-specific antigen (PSA) blood test is the accepted biomarker of tumor recurrence. PSA levels in serum correlate with disease progression, though its diagnostic accuracy is questionable. As a result, significant progress has been made in developing modified PSA tests such as PSA velocity, PSA density, 4Kscore, PSA glycoprofiling, Prostate Health Index, and the STHLM3 test. PSA, a serine protease, is secreted from the epithelial cells of the prostate. PSA has been suggested as a molecular target for prostate cancer therapy due to the fact that it is not only active in prostate tissue but also has a pivotal role on prostate cancer signaling pathways including proliferation, invasion, metastasis, angiogenesis, apoptosis, immune response, and tumor microenvironment regulation. Here, we summarize the current standing of PSA in prostate cancer progression as well as its utility in prostate cancer therapeutic approaches with an emphasis on the role of PSA in the tumor microenvironment.
      datePublished:2019-10-28T00:00:00Z
      dateModified:2019-10-28T00:00:00Z
      pageStart:333
      pageEnd:346
      sameAs:https://doi.org/10.1007/s10555-019-09815-3
      keywords:
         Prostate-specific antigen
         Prostate cancer
         Kallikrein-related peptidase
         Angiogenesis
         Immune response
         Cancer Research
         Oncology
         Biomedicine
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-019-09815-3/MediaObjects/10555_2019_9815_Fig1_HTML.png
      isPartOf:
         name:Cancer and Metastasis Reviews
         issn:
            1573-7233
            0167-7659
         volumeNumber:38
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Afshin Moradi
            affiliation:
                  name:Queensland University of Technology
                  address:
                     name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
                     type:PostalAddress
                  type:Organization
                  name:Queensland University of Technology
                  address:
                     name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Srilakshmi Srinivasan
            affiliation:
                  name:Queensland University of Technology
                  address:
                     name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
                     type:PostalAddress
                  type:Organization
                  name:Queensland University of Technology
                  address:
                     name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Judith Clements
            affiliation:
                  name:Queensland University of Technology
                  address:
                     name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
                     type:PostalAddress
                  type:Organization
                  name:Queensland University of Technology
                  address:
                     name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jyotsna Batra
            affiliation:
                  name:Queensland University of Technology
                  address:
                     name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
                     type:PostalAddress
                  type:Organization
                  name:Queensland University of Technology
                  address:
                     name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer and Metastasis Reviews
      issn:
         1573-7233
         0167-7659
      volumeNumber:38
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Queensland University of Technology
      address:
         name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
         type:PostalAddress
      name:Queensland University of Technology
      address:
         name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
         type:PostalAddress
      name:Queensland University of Technology
      address:
         name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
         type:PostalAddress
      name:Queensland University of Technology
      address:
         name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
         type:PostalAddress
      name:Queensland University of Technology
      address:
         name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
         type:PostalAddress
      name:Queensland University of Technology
      address:
         name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
         type:PostalAddress
      name:Queensland University of Technology
      address:
         name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
         type:PostalAddress
      name:Queensland University of Technology
      address:
         name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Afshin Moradi
      affiliation:
            name:Queensland University of Technology
            address:
               name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
               type:PostalAddress
            type:Organization
            name:Queensland University of Technology
            address:
               name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
               type:PostalAddress
            type:Organization
      name:Srilakshmi Srinivasan
      affiliation:
            name:Queensland University of Technology
            address:
               name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
               type:PostalAddress
            type:Organization
            name:Queensland University of Technology
            address:
               name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
               type:PostalAddress
            type:Organization
      name:Judith Clements
      affiliation:
            name:Queensland University of Technology
            address:
               name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
               type:PostalAddress
            type:Organization
            name:Queensland University of Technology
            address:
               name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
               type:PostalAddress
            type:Organization
      name:Jyotsna Batra
      affiliation:
            name:Queensland University of Technology
            address:
               name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
               type:PostalAddress
            type:Organization
            name:Queensland University of Technology
            address:
               name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
      name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
      name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
      name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
      name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
      name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
      name:School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
      name:Translational Research Institute, Queensland University of Technology, Brisbane, Australia
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(621)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

AOS
Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.48s.

LINK . SPRINGER . COM {}