We are analyzing https://link.springer.com/article/10.1007/s00775-024-02060-2.

Title:
A commentary on studies of brain iron accumulation during ageing | JBIC Journal of Biological Inorganic Chemistry
Description:
Brain iron content is widely reported to increase during “ageing”, across multiple species from nematodes, rodents (mice and rats) and humans. Given the redox-active properties of iron, there has been a large research focus on iron-mediated oxidative stress as a contributor to tissue damage during natural ageing, and also as a risk factor for neurodegenerative disease. Surprisingly, however, the majority of published studies have not investigated brain iron homeostasis during the biological time period of senescence, and thus knowledge of how brain homeostasis changes during this critical stage of life largely remains unknown. This commentary examines the literature published on the topic of brain iron homeostasis during ageing, providing a critique on limitations of currently used experimental designs. The commentary also aims to highlight that although much research attention has been given to iron accumulation or iron overload as a pathological feature of ageing, there is evidence to support functional iron deficiency may exist, and this should not be overlooked in studies of ageing or neurodegenerative disease. Graphical abstract
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Keywords {🔍}

brain, pubmed, article, google, scholar, cas, iron, ageing, senescence, adulthood, content, mice, disease, central, studies, deficiency, cells, neurons, accumulation, neurodegenerative, distribution, literature, alzheimers, hippocampus, months, homeostasis, bush, rats, tissue, aging, published, period, life, functional, hippocampal, neurosci, increase, metal, role, cell, transferrin, ferritin, xray, mapping, relative, senescent, function, hackett, elemental, res,

Topics {✒️}

x-ray fluorescence microscopy synchrotron x-ray fluorescence disease amyloid-β opposes pixel” x-ray absorption x-ray fluorescence imaging micro-x-ray absorption article download pdf quantitative susceptibility mapping metal-protein coordination environments central nervous system app/ps1 mouse model pro-inflammatory cytokines blood-brain barrier breakdown transferrin receptor-mediated internalisation low-molecular-weight complexes tumour necrosis factor-α micro-dissected tissue region cerebral protein synthesis tausted super-resolution imaging main fe-transport protein cellular iron-sulfur proteins free radical-mitochondrial theory paraffin-embedded brain tissue urrutia pj iron-deficient anemic rats iron-mediated oxidative stress levine sm cortex-derived hepcidin expression privacy choices/manage cookies aging c57bl/6j mice switzer rc 3rd leskovjan ac synchrotron access grants multiple research groups developing iron-deficient rats pilocarpine-induced epilepsy age-related fe increase xfm elemental mapping early-life iron deficiency hippocampal zn deficiency low-molecular-weight article hackett blood–brain barrier blood-brain barrier australian research council blood stream bound biochim biophys acta main force driving fe content appears iron regulatory elements

Questions {❓}

Functional Fe deficiency during ageing?
Gerlach M, Ben-Shachar D, Riederer P, Youdim MBH (1994) Altered brain metabolism of iron as a cause of neurodegenerative diseases?
Is elevated Fe in the senescent brain the result of Fe accumulation during senescence or Fe accumulation during adulthood?
What is meant by “ageing”, “aged” and “senescence”?
What is the role of Fe in the brain and how do we detect it?
Where is brain Fe located?

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