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Title[redir]:
Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier - PMC
Description:
The transcellular trafficking of iron from the blood into the brain interstitium depends on iron uptake proteins in the apical membrane of brain microvascular capillary endothelial cells and efflux proteins at the basolateral, abluminal membrane. In ...
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Keywords {🔍}
iron, google, scholar, doi, pubmed, brain, fpn, bmvec, pmc, article, free, cell, expression, cells, hepcidin, efflux, surface, bbb, mccarthy, transport, kosman, protein, blood, role, regulation, disease, duodenal, app, alzheimers, ferroportin, barrier, uptake, scp, endothelial, ferroxidase, astrocytes, basolateral, activity, mice, proteins, dmt, mechanisms, membrane, transporter, transferrin, figure, hbmvec, trafficking, apical, precursor,
Topics {✒️}
pro-inflammatory cytokine-mediated ferroportin hp/cp double-mutant mice energy-producing redox reactions amyloid-β protein oligomer cerebral β-amyloid deposition β-amyloid precursor protein pmc beta search long-term pathophysiologic consequence n-lobe monoferric transferrins canonical tf-iron uptake bmvec–astrocyte signaling network normal irp-dependent repression redox-active iron formation iron exporter ferroportin/slc40a1 lipopolysaccharide-induced parkinsonian models signaling molecules interleukin-1β hepcidin-independent retrograde recycling disease peptide β-amyloid age-related macular degeneration transferring-bound iron uptake plasma membrane proton-adenosinetriphosphatases interleukin-1β induces ceruloplasmin astrocytes produce il-1β astrocyte-secreted soluble ceruloplasmin iron-binding glycoprotein transferrin iron-regulated ferric reductase intestinal iron-transporter expression iron-export ferroxidase activity duodenal iron-regulated transporter amyloid-β peptides il-1/il-1ra release leishmania-mediated inhibition amyloid precursor protein blood-brain barrier ryan redox active iron article provide ferroportin targeting peptide canonne-hergaux neuronal paracrine signaling iron-responsive element regulatory rna sequences multi-copper ferroxidase hephaestin retinal iron overload central nervous system dmt1-binding protein poly cerebral amyloid angiogenesis cerebral amyloid angiopathy double-edged sword decreased iron efflux hbmvec tf-iron uptake
Questions {❓}
- One insight into this role follows from the question, what is the physiologic function of amyloid precursor protein (APP)?
- Role of iron in neurotoxicity: a cause for concern in the elderly?
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- How much does https://scholar.google.com/scholar_lookup?journal=Nat.%20Genet.&title=Identification%20of%20a%20ferrireductase%20required%20for%20efficient%20transferrin-dependent%20iron%20uptake%20in%20erythroid%20cells&author=R.%20S.%20Ohgami&author=D.%20R.%20Campagna&author=E.%20L.%20Greer&author=B.%20Antiochos&author=A.%20Mcdonald&volume=37&publication_year=2005&pages=1264-1269&pmid=16227996&doi=10.1038/ng1658& bring in each month?
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- https://doi.org/10.3389/fphar.2014.00173 income
- Earnings of https://scholar.google.com/scholar_lookup?journal=Front.%20Pharmacol.&title=Special%20delivery:%20distributing%20iron%20in%20the%20cytosol%20of%20mammalian%20cells&author=C.%20C.%20Philpott&author=M.-S.%20Ryu&volume=5&publication_year=2014&pages=173&pmid=25101000&doi=10.3389/fphar.2014.00173&
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=Ann.%20N%20Y%20Acad.%20Sci.&title=Human%20endothelial%20cells%20produce%20IL-6.%20Lack%20of%20responses%20to%20exogenous%20IL-6.&author=T.%20J.%20Podor&author=F.%20R.%20Jirik&author=D.%20J.%20Loskutoff&author=D.%20A.%20Carson&author=M.%20Lotz&volume=557&publication_year=1989&pages=374-387&pmid=2660697&doi=10.1111/j.1749-6632.1989.tb24030.x& generate?
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- How much money does https://scholar.google.com/scholar_lookup?journal=J.%20Immunol.&title=IL-1%20stimulates%20IL-6%20production%20in%20endothelial%20cells&author=M.%20Sironi&author=F.%20Breviario&author=P.%20Proserpio&author=A.%20Biondi&author=A.%20Vecchi&volume=142&publication_year=1989&pages=549-553&pmid=2783442& generate?
- Profit of https://doi.org/10.3389/fphar.2012.00169
- Get to know https://scholar.google.com/scholar_lookup?journal=Front.%20Pharmacol.&title=Impairment%20of%20interrelated%20iron-%20and%20copper%20homeostatic%20mechanisms%20in%20brain%20contributes%20to%20the%20pathogenesis%20of%20neurodegenerative%20disorders&author=T.%20Skj%C3%B8rringe&author=L.%20B.%20M%C3%B8ller&author=T.%20Moos&volume=3&publication_year=2012&pages=169&pmid=23055972&doi=10.3389/fphar.2012.00169&'s earnings
- Learn how profitable https://doi.org/10.1097/mco.0b013e32831ba07c is on a monthly basis
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- What are the earnings of https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Inorg.%20Chem.&title=Evidence%20that%20His349%20acts%20as%20a%20pH-inducible%20switch%20to%20accelerate%20receptor-mediated%20iron%20release%20from%20the%20C-lobe%20of%20human%20transferrin&author=A.%20Steere&author=S.%20Byrne&author=N.%20Chasteen&author=V.%20Smith&author=R.%20MacGillivray&volume=15&publication_year=2010&pages=1341-1352&pmid=20711621&doi=10.1007/s00775-010-0694-2&?
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- What's the total monthly financial gain of https://doi.org/10.1002/glia.20784?
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- https://doi.org/10.1152/japplphysiol.91076.2008 income
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- Profit of https://doi.org/10.1111/jnc.12244
- What's the profit of https://scholar.google.com/scholar_lookup?journal=J.%20Neurochem.&title=Inflammation%20alters%20the%20expression%20of%20DMT1,%20FPN1%20and%20hepcidin%20and%20it%20causes%20iron%20accumulation%20in%20central%20nervous%20system%20cells&author=P.%20Urrutia&author=P.%20Aguirre&author=A.%20Esparza&author=V.%20Tapia&author=N.%20P.%20Mena&volume=126&publication_year=2013&pages=541-549&pmid=23506423&doi=10.1111/jnc.12244&?
- Profit of https://doi.org/10.1126/science.286.5440.735
- See how much https://scholar.google.com/scholar_lookup?journal=Science&title=%CE%B2-secretase%20cleavage%20of%20Alzheimer%E2%80%99s%20amyloid%20precursor%20protein%20by%20the%20transmembrane%20aspartic%20protease%20BACE&author=R.%20Vassar&author=B.%20D.%20Bennett&author=S.%20Babu-Khan&author=S.%20Kahn&author=E.%20A.%20Mendiaz&volume=286&publication_year=1999&pages=735-741&pmid=10531052&doi=10.1126/science.286.5440.735& makes per month
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- https://scholar.google.com/scholar_lookup?journal=Nat.%20Genet.&title=Hephaestin,%20a%20ceruloplasmin%20homologue%20implicated%20in%20intestinal%20iron%20transport,%20is%20defective%20in%20the%20sla%20mouse&author=C.%20D.%20Vulpe&author=Y.%20M.%20Kuo&author=T.%20L.%20Murphy&author=L.%20Cowley&author=C.%20Askwith&volume=21&publication_year=1999&pages=195-199&pmid=9988272&doi=10.1038/5979&'s revenue stream
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- How much does https://scholar.google.com/scholar_lookup?journal=Neuroscience&title=Pro-inflammatory%20cytokine-mediated%20ferroportin%20down-regulation%20contributes%20to%20the%20nigral%20iron%20accumulation%20in%20lipopolysaccharide-induced%20Parkinsonian%20models&author=Z.%20Zhang&author=L.%20Hou&author=J.%20L.%20Song&author=N.%20Song&author=Y.%20J.%20Sun&volume=257&publication_year=2014&pages=20-30&pmid=24183966&doi=10.1016/j.neuroscience.2013.09.037& bring in each month?
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- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Cell%20Metab.&title=A%20ferroportin%20transcript%20that%20lacks%20an%20iron-responsive%20element%20enables%20duodenal%20and%20erythroid%20precursor%20cells%20to%20evade%20translational%20repression&author=D.-L.%20Zhang&author=R.%20M.%20Hughes&author=H.%20Ollivierre-Wilson&author=M.%20C.%20Ghosh&author=T.%20A.%20Rouault&volume=9&publication_year=2009&pages=461-473&pmid=19416716&doi=10.1016/j.cmet.2009.03.006&?
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- What's the financial gain of https://www.nlm.nih.gov/careers/careers.html?
- Explore the financials of https://www.nlm.nih.gov/
- Explore the financials of https://www.nih.gov/
- Monthly income for https://www.hhs.gov/
- Discover the revenue of https://www.usa.gov/
Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi