
DOI . ORG {
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Title[redir]:
Host genetic variation impacts microbiome composition across human body sites | Genome Biology | Full Text
Description:
Background The composition of bacteria in and on the human body varies widely across human individuals, and has been associated with multiple health conditions. While microbial communities are influenced by environmental factors, some degree of genetic influence of the host on the microbiome is also expected. This study is part of an expanding effort to comprehensively profile the interactions between human genetic variation and the composition of this microbial ecosystem on a genome- and microbiome-wide scale. Results Here, we jointly analyze the composition of the human microbiome and host genetic variation. By mining the shotgun metagenomic data from the Human Microbiome Project for host DNA reads, we gathered information on host genetic variation for 93 individuals for whom bacterial abundance data are also available. Using this dataset, we identify significant associations between host genetic variation and microbiome composition in 10 of the 15 body sites tested. These associations are driven by host genetic variation in immunity-related pathways, and are especially enriched in host genes that have been previously associated with microbiome-related complex diseases, such as inflammatory bowel disease and obesity-related disorders. Lastly, we show that host genomic regions associated with the microbiome have high levels of genetic differentiation among human populations, possibly indicating host genomic adaptation to environment-specific microbiomes. Conclusions Our results highlight the role of host genetic variation in shaping the composition of the human microbiome, and provide a starting point toward understanding the complex interaction between human genetics and the microbiome in the context of human evolution and disease.
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Keywords {🔍}
microbiome, pubmed, host, article, google, scholar, genetic, human, data, snps, genes, central, variation, cas, composition, analysis, additional, gut, correlated, file, found, body, genome, microbial, individuals, sites, disease, enrichment, studies, study, sequencing, project, leptin, shown, values, pathways, gene, genomewide, correlation, identified, calculated, nature, microbiota, hmp, association, set, fig, abundance, role, functional,
Topics {✒️}
imputation accuracy score human lactase persistence lactase persistence [52] springer nature high-throughput sequencing technologies surpass genome-wide significance highest ti/tv ratio high-throughput sequencing data cxcr4-mediated signaling events genomic average ti/tv host-mediated inflammation disrupts high-quality knowledge base allele sharing turnbaugh pj data sharing single nucleotide polymorphisms metagenome-wide association study population-based linkage analyses genome-wide association data privacy choices/manage cookies genome-wide association loci authors scientific editing bmc genomics genome-wide median fst fewer host-derived reads genome-wide association studies figures s12-s17 bile acid metabolism author information authors supplementary figures s1 figures s14-s19 quantitative trait locus microbiome-related complex diseases faith jj protein-coding host snps ti/tv ratio gut microbiome-host interactions sequence alignment/map format de abreu ll creative commons license filtering inter-correlated taxa bmc human microbiome project lactase enzyme human microbiome research shotgun metagenomic data microbiome 16s data hmp clinical site specific gene ontology advanced intercross population
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headline:Host genetic variation impacts microbiome composition across human body sites
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Body Site
Imputation Accuracy
Human Microbiome Project
Lactase Persistence
Microbiome Composition
Animal Genetics and Genomics
Human Genetics
Plant Genetics and Genomics
Microbial Genetics and Genomics
Bioinformatics
Evolutionary Biology
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headline:Host genetic variation impacts microbiome composition across human body sites
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Body Site
Imputation Accuracy
Human Microbiome Project
Lactase Persistence
Microbiome Composition
Animal Genetics and Genomics
Human Genetics
Plant Genetics and Genomics
Microbial Genetics and Genomics
Bioinformatics
Evolutionary Biology
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