We are analyzing https://link.springer.com/article/10.1186/ar4269.

Title:
The phenotype and genotype of rheumatoid arthritis in the Democratic Republic of Congo | Arthritis Research & Therapy
Description:
Introduction Little is known about rheumatoid arthritis in the black, particularly in Congolese, populations. Our objective was to describe the phenotype and genotype of rheumatoid arthritis (RA) in Congolese. Methods All consecutive rheumatoid arthritis (RA) patients attending Kinshasa University Hospital in a three-year time period were included. Demographics, clinical features and tobacco consumption were noted. Disease Activity Score (DAS)-28 based on the erythrocyte sedimentation rate (ESR), Health Assessment Questionnaire (HAQ), anti-citrullinated peptide antibodies (CCP) antibodies and rheumatoid factor (RF) were determined. Radiographs were scored according to Sharp-van der Heijde. On a subset of patients and controls HLA-DRB1 typing was performed. Results A total of 114 females and 14 males aged 51.2 ± 14.9 were included. Mean duration of symptoms was four years. Moderate tobacco consumption was reported in a minority of patients. DAS-28 at first visit was >5.1 and HAQ ≥0.5 in all patients. X-rays showed joint erosions and/or joint space narrowing, mostly of a moderate grade in 55.8% of patients. Anti-CCP and/or RF were present in 48.6% of patients with available data (n = 72) and in 3.0% of controls (n = 67). Radiographic changes and nodules were more frequent in RF or anti-CCP positive patients. One copy of the shared epitope was found in 13 patients (35.1%) and 3 controls (12.5%). Two copies were found in one patient (2.7%) and in one control (4.2%). Conclusion Congolese patients with RA consult long after disease onset. Despite this delay, the majority presents without major damage and is RF, anti-CCP and SE negative. We put forward the hypothesis that besides different environmental factors there is probably also a particular genetic risk profile in Congolese patients, different from the HLA-DRB1 shared epitope.
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Keywords {🔍}

patients, arthritis, rheumatoid, pubmed, article, google, scholar, hladrb, disease, study, cas, anticcp, alleles, population, rheumatology, rheum, reported, controls, shared, epitope, table, antibodies, phenotype, congolese, severity, classification, kinshasa, association, high, central, data, joint, found, frequency, observed, activity, group, african, haq, years, positive, risk, diseases, low, rheumatol, congo, access, manuscript, clinical, factor,

Topics {✒️}

deraa-bearing hla-drb1 alleles sharp-van der heijde anti-cyclic citrullinated peptides neuromusculo-skeletal research unit anti-citrullinated peptide antibodies article download pdf cyclic citrullinated peptide human leukocyte antigen-drb1 prescribing anti-rheumatic drugs hla-dr gene frequencies hla-drb1 alleles supports cyclic citrullinated peptides hla-drb1 shared epitope small joints/large joints s3p hla-drb1 alleles classic hla-drb1 s2 s2 hla-drb1 alleles proper cross-cultural validation frequent hla-drb1 alleles compare das-28-esr scores crystal arthritis hla-drb1 se test anti-ccp positive patients van leeuwen ma high das-28-esr scores controls hla-drb1 typing hla-dr alleles anti-ccp negative patients van riel pl early intensive therapy anti-rheumatic drugs full access privacy choices/manage cookies hla-drb1 genotyping jm mbuyi-muamba reported central africa article number r89 human leucocyte antigen dominant hla-dr hla-drb1 alleles hla-drb101 alleles hla-drb113 alleles hla-drb1 allele high-risk se alleles severe extra-articular manifestations hla-drb1 typing hla-dr low article malemba hla-drb1 genotype shared epitope alleles

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         headline:The phenotype and genotype of rheumatoid arthritis in the Democratic Republic of Congo
         description:Little is known about rheumatoid arthritis in the black, particularly in Congolese, populations. Our objective was to describe the phenotype and genotype of rheumatoid arthritis (RA) in Congolese. All consecutive rheumatoid arthritis (RA) patients attending Kinshasa University Hospital in a three-year time period were included. Demographics, clinical features and tobacco consumption were noted. Disease Activity Score (DAS)-28 based on the erythrocyte sedimentation rate (ESR), Health Assessment Questionnaire (HAQ), anti-citrullinated peptide antibodies (CCP) antibodies and rheumatoid factor (RF) were determined. Radiographs were scored according to Sharp-van der Heijde. On a subset of patients and controls HLA-DRB1 typing was performed. A total of 114 females and 14 males aged 51.2 ± 14.9 were included. Mean duration of symptoms was four years. Moderate tobacco consumption was reported in a minority of patients. DAS-28 at first visit was >5.1 and HAQ ≥0.5 in all patients. X-rays showed joint erosions and/or joint space narrowing, mostly of a moderate grade in 55.8% of patients. Anti-CCP and/or RF were present in 48.6% of patients with available data (n = 72) and in 3.0% of controls (n = 67). Radiographic changes and nodules were more frequent in RF or anti-CCP positive patients. One copy of the shared epitope was found in 13 patients (35.1%) and 3 controls (12.5%). Two copies were found in one patient (2.7%) and in one control (4.2%). Congolese patients with RA consult long after disease onset. Despite this delay, the majority presents without major damage and is RF, anti-CCP and SE negative. We put forward the hypothesis that besides different environmental factors there is probably also a particular genetic risk profile in Congolese patients, different from the HLA-DRB1 shared epitope.
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         dateModified:2013-08-19T00:00:00Z
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      headline:The phenotype and genotype of rheumatoid arthritis in the Democratic Republic of Congo
      description:Little is known about rheumatoid arthritis in the black, particularly in Congolese, populations. Our objective was to describe the phenotype and genotype of rheumatoid arthritis (RA) in Congolese. All consecutive rheumatoid arthritis (RA) patients attending Kinshasa University Hospital in a three-year time period were included. Demographics, clinical features and tobacco consumption were noted. Disease Activity Score (DAS)-28 based on the erythrocyte sedimentation rate (ESR), Health Assessment Questionnaire (HAQ), anti-citrullinated peptide antibodies (CCP) antibodies and rheumatoid factor (RF) were determined. Radiographs were scored according to Sharp-van der Heijde. On a subset of patients and controls HLA-DRB1 typing was performed. A total of 114 females and 14 males aged 51.2 ± 14.9 were included. Mean duration of symptoms was four years. Moderate tobacco consumption was reported in a minority of patients. DAS-28 at first visit was >5.1 and HAQ ≥0.5 in all patients. X-rays showed joint erosions and/or joint space narrowing, mostly of a moderate grade in 55.8% of patients. Anti-CCP and/or RF were present in 48.6% of patients with available data (n = 72) and in 3.0% of controls (n = 67). Radiographic changes and nodules were more frequent in RF or anti-CCP positive patients. One copy of the shared epitope was found in 13 patients (35.1%) and 3 controls (12.5%). Two copies were found in one patient (2.7%) and in one control (4.2%). Congolese patients with RA consult long after disease onset. Despite this delay, the majority presents without major damage and is RF, anti-CCP and SE negative. We put forward the hypothesis that besides different environmental factors there is probably also a particular genetic risk profile in Congolese patients, different from the HLA-DRB1 shared epitope.
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      dateModified:2013-08-19T00:00:00Z
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         phenotype
         HLA-DRB1 genotype
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         Africa
         Rheumatology
         Orthopedics
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            name:Histocompatibility and Immunogenetics Laboratory (HILA)
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      name:P Verschueren
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      name:Unit of Radiology, Kinshasa University Hospital, Kinshasa XI, Democratic Republic of Congo
      name:Experimental Laboratory Immunology, Department of Medical Diagnostic Sciences, Leuven, Belgium
      name:Histocompatibility and Immunogenetics Laboratory (HILA), Mechelen, Belgium
      name:Histocompatibility and Immunogenetics Laboratory (HILA), Mechelen, Belgium
      name:Division of Rheumatology, Department of Development and Regeneration, Neuromusculo-Skeletal Research Unit, Leuven, Belgium
      name:Division of Rheumatology, Department of Development and Regeneration, Neuromusculo-Skeletal Research Unit, Leuven, Belgium

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