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We began analyzing https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-04087-x, but it redirected us to https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-04087-x. The analysis below is for the second page.

Title[redir]:
Neoadjuvant short-course radiotherapy followed by camrelizumab and chemotherapy for locally advanced rectal cancer: 3-year survival from a phase 2 study | BMC Medicine | Full Text
Description:
Neoadjuvant short-course radiotherapy (SCRT) followed by camrelizumab and chemotherapy has shown an encouraging pathological complete response rate (48.1%, primary endpoint) in patients with locally advanced rectal cancer (LARC). Here, we present the 3-year survival outcomes. In this phase 2 trial, patients with previously untreated T3-4N0M0 or T1-4N + M0 rectal adenocarcinoma received 5 × 5 Gy SCRT over 5 days, followed by two cycles of camrelizumab (200 mg) and CAPOX regimen every 3 weeks after 1 week. Total mesorectal excision (TME) was scheduled 1 week after the completion of neoadjuvant treatment. The 3-year disease-free survival (DFS) and overall survival (OS) were evaluated in this analysis. A total of 30 patients were enrolled, of whom 28 (93.3%) had microsatellite stable status (MSS) and 27 (90.0%) underwent TME. With a median follow-up of 40.8 months, the median DFS and OS were both not reached, with the 3-year DFS and OS rates of 80.2% (95% CI 58.6–91.3) and 93.3% (95% CI 75.9–98.3), respectively. Additionally, there was a trend toward improved 3-year DFS and OS in patients with pCR, postoperative pathological node-negative status (pN0), baseline negative circumferential resection margin as assessed by MRI, baseline negative extramural venous invasion and a PD-L1 combined positive score of 1 or higher, as compared with those without these characteristics. Our data support the potential efficacy of neoadjuvant SCRT followed by camrelizumab and CAPOX regimen in LARC, as indicated by 3-year survival outcomes, suggesting that this may be an alternative therapeutic strategy, especially with the potential to address an unmet need for MSS patients. www.ClinicalTrials.gov . NCT04231552.

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  • Education
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Content Management System {📝}

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Custom-built

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Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🚀 Good Traffic: 50k - 100k visitors per month


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Keywords {🔍}

patients, pubmed, article, cancer, year, neoadjuvant, trial, rectal, google, scholar, locally, advanced, radiotherapy, survival, dfs, chemotherapy, cas, phase, immunotherapy, camrelizumab, status, scrt, chemoradiotherapy, oncol, data, versus, zhang, outcomes, pdl, study, pathological, larc, pcr, rate, results, baseline, positive, central, analysis, tao, total, tme, preoperative, emvi, bmc, shortcourse, response, received, therapy, union,

Topics {✒️}

additional information publisher' small-cell lung cancer abbreviations aes 3-year relapse-free survival 3-year disease-free survival state privacy rights methods study design pd-1/pd-l1 inhibitors pd-1/pd-l1 blockade including n-positive status locally advanced adenocarcinoma previously untreated t3-4n0m0 funding routine pd-l1 expression additional support concurrent pd-l1 blockade microsatellite instability–high deficient mismatch repair resectable lung cancer small sample size tumor mutation burden privacy choices/manage cookies rectal adenocarcinoma due low rectal disease springer nature authors scientific editing written informed consent extramural venous invasion immunotherapy-based neoadjuvant therapy pd-l1 blockade nrg-gi002 trial demonstrated information circumferential resection margin jiangsu hengrui pharmaceuticals article lin pmmr colorectal cancers pathological complete response unresectable stage iii tumor-infiltrating lymphocyte original author bmc med 23 combined positive score promising survival outcomes methods rights experienced disease recurrence 3-year survival outcomes subgroup analyses demonstrated metastatic colorectal cancer rahma oe

Schema {🗺️}

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         headline:Neoadjuvant short-course radiotherapy followed by camrelizumab and chemotherapy for locally advanced rectal cancer: 3-year survival from a phase 2 study
         description:Neoadjuvant short-course radiotherapy (SCRT) followed by camrelizumab and chemotherapy has shown an encouraging pathological complete response rate (48.1%, primary endpoint) in patients with locally advanced rectal cancer (LARC). Here, we present the 3-year survival outcomes. In this phase 2 trial, patients with previously untreated T3-4N0M0 or T1-4N + M0 rectal adenocarcinoma received 5 × 5 Gy SCRT over 5 days, followed by two cycles of camrelizumab (200 mg) and CAPOX regimen every 3 weeks after 1 week. Total mesorectal excision (TME) was scheduled 1 week after the completion of neoadjuvant treatment. The 3-year disease-free survival (DFS) and overall survival (OS) were evaluated in this analysis. A total of 30 patients were enrolled, of whom 28 (93.3%) had microsatellite stable status (MSS) and 27 (90.0%) underwent TME. With a median follow-up of 40.8 months, the median DFS and OS were both not reached, with the 3-year DFS and OS rates of 80.2% (95% CI 58.6–91.3) and 93.3% (95% CI 75.9–98.3), respectively. Additionally, there was a trend toward improved 3-year DFS and OS in patients with pCR, postoperative pathological node-negative status (pN0), baseline negative circumferential resection margin as assessed by MRI, baseline negative extramural venous invasion and a PD-L1 combined positive score of 1 or higher, as compared with those without these characteristics. Our data support the potential efficacy of neoadjuvant SCRT followed by camrelizumab and CAPOX regimen in LARC, as indicated by 3-year survival outcomes, suggesting that this may be an alternative therapeutic strategy, especially with the potential to address an unmet need for MSS patients. www.ClinicalTrials.gov . NCT04231552.
         datePublished:2025-05-09T00:00:00Z
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      headline:Neoadjuvant short-course radiotherapy followed by camrelizumab and chemotherapy for locally advanced rectal cancer: 3-year survival from a phase 2 study
      description:Neoadjuvant short-course radiotherapy (SCRT) followed by camrelizumab and chemotherapy has shown an encouraging pathological complete response rate (48.1%, primary endpoint) in patients with locally advanced rectal cancer (LARC). Here, we present the 3-year survival outcomes. In this phase 2 trial, patients with previously untreated T3-4N0M0 or T1-4N + M0 rectal adenocarcinoma received 5 × 5 Gy SCRT over 5 days, followed by two cycles of camrelizumab (200 mg) and CAPOX regimen every 3 weeks after 1 week. Total mesorectal excision (TME) was scheduled 1 week after the completion of neoadjuvant treatment. The 3-year disease-free survival (DFS) and overall survival (OS) were evaluated in this analysis. A total of 30 patients were enrolled, of whom 28 (93.3%) had microsatellite stable status (MSS) and 27 (90.0%) underwent TME. With a median follow-up of 40.8 months, the median DFS and OS were both not reached, with the 3-year DFS and OS rates of 80.2% (95% CI 58.6–91.3) and 93.3% (95% CI 75.9–98.3), respectively. Additionally, there was a trend toward improved 3-year DFS and OS in patients with pCR, postoperative pathological node-negative status (pN0), baseline negative circumferential resection margin as assessed by MRI, baseline negative extramural venous invasion and a PD-L1 combined positive score of 1 or higher, as compared with those without these characteristics. Our data support the potential efficacy of neoadjuvant SCRT followed by camrelizumab and CAPOX regimen in LARC, as indicated by 3-year survival outcomes, suggesting that this may be an alternative therapeutic strategy, especially with the potential to address an unmet need for MSS patients. www.ClinicalTrials.gov . NCT04231552.
      datePublished:2025-05-09T00:00:00Z
      dateModified:2025-05-09T00:00:00Z
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         Locally advanced rectal cancer
         Neoadjuvant
         Short-course radiotherapy
         Camrelizumab
         Survival
         Medicine/Public Health
         general
         Biomedicine
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            name:Zhenyu Lin
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      name:Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      name:Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      name:Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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