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We began analyzing https://www.tandfonline.com/doi/full/10.1128/MCB.25.11.4591-4601.2005, but it redirected us to https://www.tandfonline.com/doi/full/10.1128/MCB.25.11.4591-4601.2005. The analysis below is for the second page.

Title[redir]:
Bim Regulation of Lumen Formation in Cultured Mammary Epithelial Acini Is Targeted by Oncogenes: Molecular and Cellular Biology: Vol 25 , No 11 - Get Access
Description:
Tissue homeostasis of multicellular organisms is established and maintained by the delicate interplay between cell growth and cell death signals that are often altered in disease states such as can...

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Keywords {🔍}

access, journals, sciences, open, taylor, francis, search, online, article, bim, browse, journal, studies, log, articles, department, cells, find, environment, science, biology, lumen, cell, group, page, publish, health, social, cart, read, issue, formation, apoptosis, acinar, pdf, technology, information, register, mammary, epithelial, luminal, content, close, menu, select, calls, papers, suggester, publishing, guidance,

Topics {✒️}

social care medicine erk-mitogen-activated protein kinase journals bioscience molecular downloaded article pdf twitter page taylor harvard medical school article /doi/full/10 francis group mammary acinar morphogenesis journal search calls downloaded article pdfs cart search centrally localized cells american cancer society nsf predoctoral fellowship limited period advanced search molecular find guidance journals books receive personalised research proapoptotic protein bim crossref citations access rights institution access read lists articles published online applicable share back citing articles based journals browse selectively trigger apoptosis cellular biology list stimulates cell proliferation open azad bonni2 department delays lumen formation reduce bim expression information date register journals a luminal filling article https luminal apoptosis register log crossref icon lumen formation cell biology bim expression taylor publish issues volume 25

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      articleSection:Signal Transduction
      name:Bim Regulation of Lumen Formation in Cultured Mammary Epithelial Acini Is Targeted by Oncogenes
      headline:Bim Regulation of Lumen Formation in Cultured Mammary Epithelial Acini Is Targeted by Oncogenes
      abstract:Epithelial cells organize into cyst-like structures that contain a spherical monolayer of cells that enclose a central lumen. Using a three-dimensional basement membrane culture model in which mammary epithelial cells form hollow, acinus-like structures, we previously demonstrated that lumen formation is achieved, in part, through apoptosis of centrally localized cells. We demonstrate that the proapoptotic protein Bim may selectively trigger apoptosis of the centrally localized acinar cells, leading to temporally controlled lumen formation. Bim is not detectable during early stages of three-dimensional mammary acinar morphogenesis and is then highly upregulated in all cells of acini, coincident with detection of apoptosis in the centrally localized acinar cells. Inhibition of Bim expression by RNA interference transiently blocks luminal apoptosis and delays lumen formation. Oncogenes that induce acinar luminal filling, such as ErbB2 and v-Src, suppress expression of Bim through a pathway dependent on Erk-mitogen-activated protein kinase; however, HPV 16 E7, an oncogene that stimulates cell proliferation but not luminal filling, is unable to reduce Bim expression. Thus, Bim is a critical regulator of luminal apoptosis during mammary acinar morphogenesis in vitro and may be an important target of oncogenes that disrupt glandular epithelial architecture.
      description:Epithelial cells organize into cyst-like structures that contain a spherical monolayer of cells that enclose a central lumen. Using a three-dimensional basement membrane culture model in which mammary epithelial cells form hollow, acinus-like structures, we previously demonstrated that lumen formation is achieved, in part, through apoptosis of centrally localized cells. We demonstrate that the proapoptotic protein Bim may selectively trigger apoptosis of the centrally localized acinar cells, leading to temporally controlled lumen formation. Bim is not detectable during early stages of three-dimensional mammary acinar morphogenesis and is then highly upregulated in all cells of acini, coincident with detection of apoptosis in the centrally localized acinar cells. Inhibition of Bim expression by RNA interference transiently blocks luminal apoptosis and delays lumen formation. Oncogenes that induce acinar luminal filling, such as ErbB2 and v-Src, suppress expression of Bim through a pathway dependent on Erk-mitogen-activated protein kinase; however, HPV 16 E7, an oncogene that stimulates cell proliferation but not luminal filling, is unable to reduce Bim expression. Thus, Bim is a critical regulator of luminal apoptosis during mammary acinar morphogenesis in vitro and may be an important target of oncogenes that disrupt glandular epithelial architecture.
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            name:Mauricio J. Reginato
            type:Person
            name:Kenna R. Mills
            type:Person
            name:Esther B. E. Becker
            type:Person
            name:Danielle K. Lynch
            type:Person
            name:Azad Bonni
            type:Person
            name:Senthil K. Muthuswamy
            type:Person
            name:Joan S. Brugge
      pageStart:4591
      pageEnd:4601
      datePublished:2023-03-27
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      name:Esther B. E. Becker
      name:Danielle K. Lynch
      name:Azad Bonni
      name:Senthil K. Muthuswamy
      name:Joan S. Brugge
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