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samples, cancer, breast, molecular, article, metabric, fig, ember, scores, scanb, pubmed, data, signaling, genes, google, scholar, tcga, index, score, analysis, ihc, patients, average, estrogen, clinical, cohorts, embedding, sample, expression, response, cas, gene, supplementary, patient, therapy, endocrine, cohort, figure, early, nature, subtypes, receptor, information, central, space, poetic, pcpc, signatures, rnaseq, tumor,

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loading [mathjax]/jax/output/html-css/config nature portfolio code availability author information authors pi3k/akt/mtor signaling drive data availability editing molecular markers adjacent sections regional office nature 406 nature 486 nature 490 nature 462 nature leveraging patient-partnered research encompass single-sample-based approaches34 powerful tools $${\rm{cv}}=\frac{{\rm{standard pi3k/akt/mtor signaling pgc-1α-responsive genes involved figures initiative sharing original author experimental cancer research author correspondence reprints provided additional information additional biological information early-stage breast cancer io/transcriptomics epithelial-mesenchymal transition open manner35 revolutionized biomedical research cancer research npj breast cancer accession code gse105777 io/molecular_landscape including stephen-john sammut asco/cap guideline update discussion genomics data rna sequencing-based datasets similar content breast cancer index early breast cancer additional biological features large-scale multicenter infrastructure ember-based estrogen receptor

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Social Networks {👍}(2)

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• https://data.mendeley.com/datasets/yzxtxn4nmd
• https://chronchi.github.io/transcriptomics
• https://github.com/chronchi/ember
• https://github.com/chronchi/molecular_landscape
• https://chronchi.github.io/molecular_landscape
• https://doi.org/10.1023%2FA%3A1020299707510
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12408373
• http://scholar.google.com/scholar_lookup?&title=Estrogen%20receptor%20breast%20cancer%20phenotypes%20in%20the%20Surveillance%2C%20Epidemiology%2C%20and%20End%20Results%20database&journal=Breast%20Cancer%20Res%20Treat.&doi=10.1023%2FA%3A1020299707510&volume=76&pages=27-36&publication_year=2002&author=Anderson%2CWF&author=Chatterjee%2CN&author=Ershler%2CWB&author=Brawley%2COW
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• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=31928404
• http://scholar.google.com/scholar_lookup?&title=Estrogen%20and%20Progesterone%20Receptor%20Testing%20in%20Breast%20Cancer%3A%20ASCO%2FCAP%20Guideline%20Update&journal=J.%20Clin.%20Oncol.&doi=10.1200%2FJCO.19.02309&volume=38&pages=1346-1366&publication_year=2020&author=Allison%2CKH
• https://doi.org/10.1038%2F35021093
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10963602
• http://scholar.google.com/scholar_lookup?&title=Molecular%20portraits%20of%20human%20breast%20tumours&journal=Nature&doi=10.1038%2F35021093&volume=406&pages=747-752&publication_year=2000&author=Perou%2CCM
• https://doi.org/10.1038%2Fnature10983
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22522925
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440846
• http://scholar.google.com/scholar_lookup?&title=The%20genomic%20and%20transcriptomic%20architecture%20of%202%2C000%20breast%20tumours%20reveals%20novel%20subgroups&journal=Nature&doi=10.1038%2Fnature10983&volume=486&pages=346-352&publication_year=2012&author=Curtis%2CC
• https://link.springer.com/doi/10.1186/bcr3038
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21999244
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262211
• http://scholar.google.com/scholar_lookup?&title=Prognostic%20utility%20of%20the%20breast%20cancer%20index%20and%20comparison%20to%20Adjuvant%21%20Online%20in%20a%20clinical%20case%20series%20of%20early%20breast%20cancer&journal=Breast%20Cancer%20Res.&doi=10.1186%2Fbcr3038&volume=13&publication_year=2011&author=Jankowitz%2CRC
• https://doi.org/10.1056%2FNEJMoa1602253
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=27557300
• http://scholar.google.com/scholar_lookup?&title=70-Gene%20Signature%20as%20an%20Aid%20to%20Treatment%20Decisions%20in%20Early-Stage%20Breast%20Cancer&journal=N.%20Engl.%20J.%20Med&doi=10.1056%2FNEJMoa1602253&volume=375&pages=717-729&publication_year=2016&author=Cardoso%2CF
• https://doi.org/10.1158%2F1078-0432.CCR-11-0926
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21807638
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• https://doi.org/10.1056%2FNEJMoa1804710
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=29860917
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172658
• http://scholar.google.com/scholar_lookup?&title=Adjuvant%20Chemotherapy%20Guided%20by%20a%2021-Gene%20Expression%20Assay%20in%20Breast%20Cancer&journal=N.%20Engl.%20J.%20Med.&doi=10.1056%2FNEJMoa1804710&volume=379&pages=111-121&publication_year=2018&author=Sparano%2CJA
• https://doi.org/10.1200%2FJCO.2008.18.1370
• http://scholar.google.com/scholar_lookup?&title=Supervised%20Risk%20Predictor%20of%20Breast%20Cancer%20Based%20on%20Intrinsic%20Subtypes&journal=JCO&doi=10.1200%2FJCO.2008.18.1370&volume=27&pages=1160-1167&publication_year=2009&author=Parker%2CJS
• https://doi.org/10.1200%2FJCO.20.00853
• http://scholar.google.com/scholar_lookup?&title=Molecular%20Drivers%20of%20Oncotype%20DX%2C%20Prosigna%2C%20EndoPredict%2C%20and%20the%20Breast%20Cancer%20Index%3A%20A%20TransATAC%20Study&journal=JCO&doi=10.1200%2FJCO.20.00853&volume=39&pages=126-135&publication_year=2021&author=Buus%2CR
• https://doi.org/10.15252%2Femmm.202012118
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32926574
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539222
• http://scholar.google.com/scholar_lookup?&title=The%20mutational%20landscape%20of%20the%20SCAN-B%20real-world%20primary%20breast%20cancer%20transcriptome&journal=EMBO%20Mol.%20Med.&doi=10.15252%2Femmm.202012118&volume=12&publication_year=2020&author=Brueffer%2CC
• https://doi.org/10.1093%2Fjncics%2Fpkab028
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=33937624
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060794
• http://scholar.google.com/scholar_lookup?&title=Preexisting%20Somatic%20Mutations%20of%20Estrogen%20Receptor%20Alpha%20%28ESR1%29%20in%20Early-Stage%20Primary%20Breast%20Cancer&journal=JNCI%20Cancer%20Spectr.&doi=10.1093%2Fjncics%2Fpkab028&volume=5&publication_year=2021&author=Dahlgren%2CM
• https://doi.org/10.1158%2F1078-0432.CCR-19-0075
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=31340938
• http://scholar.google.com/scholar_lookup?&title=Prediction%20of%20Lymph%20Node%20Metastasis%20in%20Breast%20Cancer%20by%20Gene%20Expression%20and%20Clinicopathological%20Models%3A%20Development%20and%20Validation%20within%20a%20Population-Based%20Cohort&journal=Clin.%20Cancer%20Res.&doi=10.1158%2F1078-0432.CCR-19-0075&volume=25&pages=6368-6381&publication_year=2019&author=Dihge%2CL
• https://link.springer.com/doi/10.1186/s13073-015-0131-9
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25722745
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341872
• http://scholar.google.com/scholar_lookup?&title=The%20Sweden%20Cancerome%20Analysis%20Network%20-%20Breast%20%28SCAN-B%29%20Initiative%3A%20a%20large-scale%20multicenter%20infrastructure%20towards%20implementation%20of%20breast%20cancer%20genomic%20analyses%20in%20the%20clinical%20routine&journal=Genome%20Med.&doi=10.1186%2Fs13073-015-0131-9&volume=7&publication_year=2015&author=Saal%2CLH
• https://doi.org/10.1038%2Fs41523-022-00465-3
• http://scholar.google.com/scholar_lookup?&title=RNA%20sequencing-based%20single%20sample%20predictors%20of%20molecular%20subtype%20and%20risk%20of%20recurrence%20for%20clinical%20assessment%20of%20early-stage%20breast%20cancer&journal=npj%20Breast%20Cancer&doi=10.1038%2Fs41523-022-00465-3&volume=8&pages=1-17&publication_year=2022&author=Staaf%2CJ
• https://doi.org/10.1038%2Fnature11412
• http://scholar.google.com/scholar_lookup?&title=Comprehensive%20molecular%20portraits%20of%20human%20breast%20tumours&journal=Nature&doi=10.1038%2Fnature11412&volume=490&pages=61-70&publication_year=2012&author=Koboldt%2CDC
• https://doi.org/10.1093%2Fnar%2Fgkaa802
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=32997146
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641762
• http://scholar.google.com/scholar_lookup?&title=Stable%20gene%20expression%20for%20normalisation%20and%20single-sample%20scoring&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkaa802&volume=48&publication_year=2020&author=Bhuva%2CDD&author=Cursons%2CJ&author=Davis%2CMJ
• https://doi.org/10.1111%2Fhis.13089
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=27648723
• http://scholar.google.com/scholar_lookup?&title=Further%20evidence%20to%20support%20bimodality%20of%20oestrogen%20receptor%20expression%20in%20breast%20cancer&journal=Histopathology&doi=10.1111%2Fhis.13089&volume=70&pages=456-465&publication_year=2017&author=Muftah%2CAA
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• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21546393
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106198
• http://scholar.google.com/scholar_lookup?&title=Molecular%20signatures%20database%20%28MSigDB%29%203.0&journal=Bioinformatics&doi=10.1093%2Fbioinformatics%2Fbtr260&volume=27&pages=1739-1740&publication_year=2011&author=Liberzon%2CA
• https://doi.org/10.1038%2Fs41592-019-0619-0
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=31740819
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• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=29088770
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• https://doi.org/10.17632/yzxtxn4nmd.3
• https://doi.org/10.1038%2Fs41467-018-04129-4
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=29713003
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• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=35668111
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• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=31856832
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• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22752290
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• http://scholar.google.com/scholar_lookup?&title=PAM50%20assay%20and%20the%20three-gene%20model%20for%20identifying%20the%20major%20and%20clinically%20relevant%20molecular%20subtypes%20of%20breast%20cancer&journal=Breast%20Cancer%20Res%20Treat.&doi=10.1007%2Fs10549-012-2143-0&volume=135&pages=301-306&publication_year=2012&author=Prat%2CA&author=Parker%2CJS&author=Fan%2CC&author=Perou%2CCM
• https://doi.org/10.1093%2Fjncimonographs%2Flgr034
• http://scholar.google.com/scholar_lookup?&title=Endocrine%20Therapy%2C%20New%20Biologicals%2C%20and%20New%20Study%20Designs%20for%20Presurgical%20Studies%20in%20Breast%20Cancer&journal=JNCI%20Monogr.&doi=10.1093%2Fjncimonographs%2Flgr034&volume=2011&pages=120-123&publication_year=2011&author=Dowsett%2CM
• https://link.springer.com/doi/10.1186/s12859-018-2435-4
• http://scholar.google.com/scholar_lookup?&title=Single%20sample%20scoring%20of%20molecular%20phenotypes&journal=BMC%20Bioinforma.&doi=10.1186%2Fs12859-018-2435-4&volume=19&publication_year=2018&author=Foroutan%2CM
• https://doi.org/10.1038%2Fnature08460
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19847166
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783335
• http://scholar.google.com/scholar_lookup?&title=Systematic%20RNA%20interference%20reveals%20that%20oncogenic%20KRAS-driven%20cancers%20require%20TBK1&journal=Nature&doi=10.1038%2Fnature08460&volume=462&pages=108-112&publication_year=2009&author=Barbie%2CDA
• https://doi.org/10.1038%2Fs41523-019-0111-0
• http://scholar.google.com/scholar_lookup?&title=SETER%2FPR%3A%20a%20robust%2018-gene%20predictor%20for%20sensitivity%20to%20endocrine%20therapy%20for%20metastatic%20breast%20cancer&journal=npj%20Breast%20Cancer&doi=10.1038%2Fs41523-019-0111-0&volume=5&pages=1-8&publication_year=2019&author=Sinn%2CBV
• https://link.springer.com/doi/10.1186/s12859-017-1925-0
• http://scholar.google.com/scholar_lookup?&title=Integration%20of%20RNA-Seq%20data%20with%20heterogeneous%20microarray%20data%20for%20breast%20cancer%20profiling&journal=BMC%20Bioinforma.&doi=10.1186%2Fs12859-017-1925-0&volume=18&publication_year=2017&author=Castillo%2CD
• https://doi.org/10.1093%2Fnar%2Fgkab554
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=34214174
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464058
• http://scholar.google.com/scholar_lookup?&title=Rank-in%3A%20enabling%20integrative%20analysis%20across%20microarray%20and%20RNA-seq%20for%20cancer&journal=Nucleic%20Acids%20Res.&doi=10.1093%2Fnar%2Fgkab554&volume=49&publication_year=2021&author=Tang%2CK
• https://doi.org/10.1016%2FS1470-2045%2810%2970008-5
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20181526
• http://scholar.google.com/scholar_lookup?&title=Breast%20cancer%20molecular%20profiling%20with%20single%20sample%20predictors%3A%20a%20retrospective%20analysis&journal=Lancet%20Oncol.&doi=10.1016%2FS1470-2045%2810%2970008-5&volume=11&pages=339-349&publication_year=2010&author=Weigelt%2CB
• https://doi.org/10.1038%2Fs41467-022-32523-6
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=36008376
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• http://scholar.google.com/scholar_lookup?&title=Epithelial-mesenchymal%20plasticity%20determines%20estrogen%20receptor%20positive%20breast%20cancer%20dormancy%20and%20epithelial%20reconversion%20drives%20recurrence&journal=Nat.%20Commun.&doi=10.1038%2Fs41467-022-32523-6&volume=13&publication_year=2022&author=Aouad%2CP
• https://doi.org/10.1200%2FJCO.2023.41.17_suppl.LBA500
• http://scholar.google.com/scholar_lookup?&title=Ribociclib%20and%20endocrine%20therapy%20as%20adjuvant%20treatment%20in%20patients%20with%20HR%2B%2FHER2-%20early%20breast%20cancer%3A%20Primary%20results%20from%20the%20phase%20III%20NATALEE%20trial&journal=JCO&doi=10.1200%2FJCO.2023.41.17_suppl.LBA500&volume=41&pages=LBA500-LBA500&publication_year=2023&author=Slamon%2CDJ
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• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=37256976
• http://scholar.google.com/scholar_lookup?&title=Capivasertib%20in%20Hormone%20Receptor%E2%80%93Positive%20Advanced%20Breast%20Cancer&journal=N.%20Engl.%20J.%20Med.&doi=10.1056%2FNEJMoa2214131&volume=388&pages=2058-2070&publication_year=2023&author=Turner%2CNC
• https://link.springer.com/doi/10.1186/s13058-019-1223-z
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=31892336
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938628
• http://scholar.google.com/scholar_lookup?&title=Impact%20of%20aromatase%20inhibitor%20treatment%20on%20global%20gene%20expression%20and%20its%20association%20with%20antiproliferative%20response%20in%20ER%2B%20breast%20cancer%20in%20postmenopausal%20patients&journal=Breast%20Cancer%20Res.&doi=10.1186%2Fs13058-019-1223-z&volume=22&publication_year=2019&author=Gao%2CQ
• https://doi.org/10.1038%2Fs41591-020-01168-7
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=33462444
• http://scholar.google.com/scholar_lookup?&title=The%20androgen%20receptor%20is%20a%20tumor%20suppressor%20in%20estrogen%20receptor%E2%80%93positive%20breast%20cancer&journal=Nat.%20Med&doi=10.1038%2Fs41591-020-01168-7&volume=27&pages=310-320&publication_year=2021&author=Hickey%2CTE
• https://link.springer.com/doi/10.1007/s10549-009-0436-8
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19533338
• http://scholar.google.com/scholar_lookup?&title=Androgen%20receptor%20overexpression%20induces%20tamoxifen%20resistance%20in%20human%20breast%20cancer%20cells&journal=Breast%20Cancer%20Res%20Treat.&doi=10.1007%2Fs10549-009-0436-8&volume=121&pages=1-11&publication_year=2010&author=Amicis%2CF
• https://link.springer.com/doi/10.1186/s13058-022-01556-6
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=36096872
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9466340
• http://scholar.google.com/scholar_lookup?&title=Relationship%20between%20ER%20expression%20by%20IHC%20or%20mRNA%20with%20Ki67%20response%20to%20aromatase%20inhibition%3A%20a%20POETIC%20study&journal=Breast%20Cancer%20Res.&doi=10.1186%2Fs13058-022-01556-6&volume=24&publication_year=2022&author=Lopez-Knowles%2CE
• https://doi.org/10.1093%2Fbioinformatics%2Fbtm254
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17496320
• http://scholar.google.com/scholar_lookup?&title=GEOquery%3A%20a%20bridge%20between%20the%20Gene%20Expression%20Omnibus%20%28GEO%29%20and%20BioConductor&journal=Bioinformatics&doi=10.1093%2Fbioinformatics%2Fbtm254&volume=23&pages=1846-1847&publication_year=2007&author=Davis%2CS&author=Meltzer%2CPS
• https://doi.org/10.1093%2Fbioinformatics%2Fbtp616
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19910308
• http://scholar.google.com/scholar_lookup?&title=edgeR%3A%20a%20Bioconductor%20package%20for%20differential%20expression%20analysis%20of%20digital%20gene%20expression%20data&journal=Bioinformatics&doi=10.1093%2Fbioinformatics%2Fbtp616&volume=26&pages=139-140&publication_year=2010&author=Robinson%2CMD&author=McCarthy%2CDJ&author=Smyth%2CGK
• https://link.springer.com/doi/10.1186/1471-2105-14-7
• http://scholar.google.com/scholar_lookup?&title=GSVA%3A%20gene%20set%20variation%20analysis%20for%20microarray%20and%20RNA-Seq%20data&journal=BMC%20Bioinforma.&doi=10.1186%2F1471-2105-14-7&volume=14&publication_year=2013&author=H%C3%A4nzelmann%2CS&author=Castelo%2CR&author=Guinney%2CJ
• https://doi.org/10.1038%2Fng1180
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12808457
• http://scholar.google.com/scholar_lookup?&title=PGC-1%CE%B1-responsive%20genes%20involved%20in%20oxidative%20phosphorylation%20are%20coordinately%20downregulated%20in%20human%20diabetes&journal=Nat.%20Genet&doi=10.1038%2Fng1180&volume=34&pages=267-273&publication_year=2003&author=Mootha%2CVK
• https://doi.org/10.5281/zenodo.1308151
• https://citation-needed.springer.com/v2/references/10.1038/s41523-024-00665-z?format=refman&flavour=references
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Carlos%20Ronchi
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Carlos%20Ronchi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Syed%20Haider
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Syed%20Haider%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Cathrin%20Brisken
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Cathrin%20Brisken%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• https://static-content.springer.com/esm/art%3A10.1038%2Fs41523-024-00665-z/MediaObjects/41523_2024_665_MOESM1_ESM.pdf
• http://creativecommons.org/licenses/by/4.0/
• https://s100.copyright.com/AppDispatchServlet?title=EMBER%20creates%20a%20unified%20space%20for%20independent%20breast%20cancer%20transcriptomic%20datasets%20enabling%20precision%20oncology&author=Carlos%20Ronchi%20et%20al&contentID=10.1038%2Fs41523-024-00665-z©right=The%20Author%28s%29&publication=2374-4677&publicationDate=2024-07-09&publisherName=SpringerNature&orderBeanReset=true&oa=CC%20BY
• https://crossmark.crossref.org/dialog/?doi=10.1038/s41523-024-00665-z
• https://citation-needed.springer.com/v2/references/10.1038/s41523-024-00665-z?format=refman&flavour=citation
• https://www.protocols.io/
• https://www.natureindex.com/
• http://www.naturechina.com
• https://www.natureasia.com/ja-jp

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