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We began analyzing https://www.nature.com/articles/6692097, but it redirected us to https://www.nature.com/articles/6692097. The analysis below is for the second page.

Title[redir]:
Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes | British Journal of Cancer
Description:
Exposure to ultraviolet radiation may reduce prostate cancer risk, suggesting that polymorphism in genes that mediate host pigmentation will be associated with susceptibility to this cancer. We studied 210 prostate cancer cases and 155 controls to determine whether vitamin D receptor (VDR, Taql and Fokl variants), tyrosinase (TYR, codon 192 variant) and melanocortin-1 receptor (MC1R, Arg151Cys, Arg160Trp, Val92Met, Asp294His and Asp84Glu variants) genotypes are associated with risk. UV exposure was determined using a questionnaire. MC1R Arg160/Arg160 homozygotes were at increased risk (P = 0.027, odds ratio = 1.94) while TYR A2/A2 homozygotes were at reduced risk of prostate cancer (P = 0.033, odds ratio = 0.48). These associations remained significant after correction for UV-exposure. Stratification of cases and controls by quartiles of exposure, showed that the protective effect of TYR A1A2 (P = 0.006, odds ratio 0.075) and A2A2 (P = 0.003, odds ratio 0.055) was particularly strong in subjects who had received the greatest exposure. Our data show for the first time, that allelism in genes linked with skin pigment synthesis is associated with prostate cancer risk possibly because it mediates the protective effects of UV. Importantly, susceptibility is associated with an interaction between host predisposition and exposure. © 2001 Cancer Research Campaign http://www.bjcancer.com

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Keywords {🔍}

cancer, article, google, scholar, cas, prostate, nature, risk, receptor, skin, exposure, ultraviolet, radiation, vitamin, content, res, cookies, open, melanocortin, fryer, susceptibility, privacy, data, journal, access, jones, strange, pigmentation, research, polymorphisms, pubmed, staffordshire, british, november, genotypes, luscombe, french, liu, polymorphism, variants, tyr, odds, ratio, human, hormone, garland, sunlight, gene, association, advertising,

Topics {✒️}

nature portfolio privacy policy nature genet 11 nature advertising social media 0/ reprints mc1r arg160/arg160 homozygotes tyr a2/a2 homozygotes permissions personal data receptor gene polymorphism data protection data show pigmentation-related phenotypes privacy prostate cancer risk prostate specific antigen prostate cancer histopathology prostate cancer mortality clinical risk factors journals search log explore content similar content european economic area skin pigment synthesis cell lines derived renal transplant recipients breast cancer mortality melanocytic skin cancer accepting optional cookies reduce cancer risk prostate cancer patients article luscombe melanoma skin cancer manage preferences mediate host pigmentation garland fc garland cf hutchinson pe human pigmentation genetics skin deep hypothesis involving exposure north staffordshire hospital associations remained significant content association explained solely article cite ingles sa melanocortin-1 receptor genotypes

Questions {❓}

Garland CF and Garland FC (1980) Do sunlight and vitamin D reduce the likelihood of colon cancer?
Palmer JS, Duffy DL, Box NF, Aitken JF, O’Gorman LE, Green AC, Haywood NK, Martin NG and Sturm RA (2000) Melanocortin-1 receptor polymorphisms and risk of melanoma: Is the association explained solely by pigmentation phenotype?
Studzinski GP and Moore DC (1995) Sunlight– Can it prevent as well as cause cancer?
Young JM, Muscatello DJ and Ward JE (2000) Are men with lower urinary tract symptoms at increased risk of prostate cancer?

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